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pro vyhledávání: '"Jek Howe Fong"'
Autor:
Matiullah Khan, Chien-Shing Chen, Dawn Sijin Nin, Angela Ping Ping Ng, Divya Venkataraman, Jek Howe Fong
Publikováno v:
Molecular Cancer Therapeutics. 6:2240-2248
We have recently reported that PML-RAR–induced misfolding of the N-CoR protein could be reversed by retinoic acid (RA), a therapeutic agent that promotes differentiation of acute promyelocytic leukemia (APL) cells. This finding suggests a role of m
Autor:
Dawn Sijin Nin, Jayshree L. Hirpara, Matiullah Khan, Chien-Shing Chen, Jek Howe Fong, Shazib Pervaiz, Angela Ping Ping Ng, Norio Asou
Publikováno v:
Cancer research. 66(20)
We have recently reported that accumulation of misfolded nuclear hormone receptor corepressor (N-CoR) as insoluble protein aggregates in acute promyelocytic leukemia (APL) cells induces endoplasmic reticulum (ER) stress and activates unfolded protein