Zobrazeno 1 - 10
of 37
pro vyhledávání: '"Jehad Almaliti"'
Autor:
Jan Silhan, Pavla Fajtova, Jitka Bartosova, Brianna M. Hurysz, Jehad Almaliti, Yukiko Miyamoto, Lars Eckmann, William H. Gerwick, Anthony J. O’Donoghue, Evzen Boura
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-12 (2024)
Abstract The proteasome is a proteolytic enzyme complex essential for protein homeostasis in mammalian cells and protozoan parasites like Trichomonas vaginalis (Tv), the cause of the most common, non-viral sexually transmitted disease. Tv and other p
Externí odkaz:
https://doaj.org/article/abd0f24bf800449e83e758d89f1c5a2b
Autor:
Jehad Almaliti, Momen Alhindy, Michael C. Yoon, Vivian Hook, Tadeusz F. Molinski, Anthony J. O’Donoghue, William H. Gerwick
Publikováno v:
ACS Omega, Vol 9, Iss 3, Pp 3997-4003 (2024)
Externí odkaz:
https://doaj.org/article/c37339e22da74790a82befae2753392d
Publikováno v:
Metabolites, Vol 13, Iss 8, p 948 (2023)
Metabolomics is an analytical approach that involves profiling and comparing the metabolites present in biological samples. This scoping review article offers an overview of current metabolomics approaches and their utilization in evaluating metaboli
Externí odkaz:
https://doaj.org/article/a3ab2c222ae8448db07e14aa5ee1c5ba
Autor:
Ayed M. Al-Abdallat, Batool K. Adayileh, Jamal S. Sawwan, Rida Shibli, Tamara S. Al-Qudah, Bashaer Abu-Irmaileh, Randa N. Albdaiwi, Jehad Almaliti, Yasser Bustanji
Publikováno v:
Metabolites, Vol 13, Iss 4, p 537 (2023)
Commiphora gileadensis L. is an important endangered medicinal plant that belongs to the family Burseraceae. In this study, C. gileadensis callus culture was established successfully using mature leaves as explants cultured on Murashige and Skoog (MS
Externí odkaz:
https://doaj.org/article/81a1b41f8436429787fbfe960a8c2410
Autor:
Jehad Almaliti, Muhammed Alzweiri, Momen Alhindy, Tamam Al-Helo, Ibrahim Daoud, Raghad Deknash, C. Benjamin Naman, Bashaer Abu-Irmaileh, Yasser Bustanji, Islam Hamad
Publikováno v:
Molecules, Vol 27, Iss 7, p 2261 (2022)
Obesity is the most common nutritional disorder in the developed world and is associated with important comorbidities. Pancreatic lipase (PL) inhibitors play a key role in the metabolism of human fat. A series of novel epoxyketones peptide derivative
Externí odkaz:
https://doaj.org/article/4365af779683477f8086afbe412e9dcb
Autor:
Christopher A. Leber, C. Benjamin Naman, Lena Keller, Jehad Almaliti, Eduardo J. E. Caro-Diaz, Evgenia Glukhov, Valsamma Joseph, T. P. Sajeevan, Andres Joshua Reyes, Jason S. Biggs, Te Li, Ye Yuan, Shan He, Xiaojun Yan, William H. Gerwick
Publikováno v:
Marine Drugs, Vol 18, Iss 10, p 515 (2020)
The tropical marine cyanobacterium Moorena bouillonii occupies a large geographic range across the Indian and Western Tropical Pacific Oceans and is a prolific producer of structurally unique and biologically active natural products. An ensemble of c
Externí odkaz:
https://doaj.org/article/e68691c31f534a5ca9a3b1ea660216df
Autor:
Jehad Almaliti, William H. Gerwick
Publikováno v:
Expert Opinion on Drug Discovery. :1-5
Autor:
Pavla Fajtova, Brianna M Hurysz, Yukiko Miyamoto, Mateus Serafim, Zhenze Jiang, Diego F. Trujillo, Lawrence Liu, Urvashi Somani, Jehad Almaliti, Samuel A. Myers, Conor R. Caffrey, William H. Gerwick, Christopher J Kirk, Evzen Boura, Lars Eckmann, Anthony J O’Donoghue
Publikováno v:
bioRxiv
The protozoan parasite,Trichomonas vaginalis(Tv) causes trichomoniasis, the most common, non-viral, sexually transmitted infection in the world. Only two closely related drugs are approved for its treatment. The accelerating emergence of resistance t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d83517afa78a9248add719062c31304c
https://europepmc.org/articles/PMC10104049/
https://europepmc.org/articles/PMC10104049/
Autor:
Jehad Almaliti, Pavla Fajtová, Jaeson Calla, Gregory M. LaMonte, Mudong Feng, Frances Rocamora, Sabine Ottilie, Evgenia Glukhov, Evzen Boura, Raymond T. Suhandynata, Jeremiah D. Momper, Michael K. Gilson, Elizabeth A. Winzeler, William H. Gerwick, Anthony J. O'Donoghue
Here we present remarkable epoxyketone-based proteasome inhibitors with low nanomolar in vitro potency for blood-stage Plasmodium falciparum and low cytotoxicity for human cells. Our best compound has more than 2,000-fold greater selectivity for eryt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od______2659::b8eb6ef78093603656917035ab9eee71
https://zenodo.org/record/7655290
https://zenodo.org/record/7655290
Publikováno v:
ChemistrySelect. 6:12461-12465