Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Jeha Jeon"'
Autor:
Jisun Kim, Jeha Jeon, Bin Song, Nayeon Lee, Sanghyeok Ko, Young Cha, Pierre Leblanc, Hyemyung Seo, Kwang-Soo Kim
Publikováno v:
Nat Protoc
To fully realize the potential of human pluripotent stem cells (hPSCs) for both therapeutic and research purposes it is critical to follow an efficient and reliable in vitro differentiation method that is based on optimal physical, chemical, and deve
Autor:
Hyemyung Seo, Taewoo Kim, Jeha Jeon, Yeongwon Park, Haneul Noh, Jin Sun Park, Jooeui Kim, Hee-Sun Kim
Publikováno v:
Biomolecules & Therapeutics
Parkinson's disease (PD) is a neurodegenerative disorder that involves the loss of dopaminergic neurons in the substantia nigra (SN). Matrix metalloproteinases-8 (MMP-8), neutrophil collagenase, is a functional player in the progressive pathology of
Autor:
Jeffrey Schweitzer, Young Joo Cha, Otto Rapalino, Sanghyeok Ko, Bruce M. Cohen, Quanzheng Li, Carolyn Neff, Taewoo Kim, Bob S. Carter, Jisun Kim, Tae-Yoon Park, Sek Won Kong, Kyungsang Kim, In-Hee Lee, Kwang-Soo Kim, Bin Song, Jerome Ritz, Gregory A. Petsko, Todd M. Herrington, Pierre Leblanc, Hyemyung Seo, Jeha Jeon, Michael G. Kaplitt, Nayeon Lee, Claire Henchcliffe
Publikováno v:
New England Journal of Medicine. 382:1926-1932
Summary We report the implantation of patient-derived midbrain dopaminergic progenitor cells, differentiated in vitro from autologous induced pluripotent stem cells (iPSCs), in a patient with idiop...
Autor:
Jeha Jeon, Bruce M. Cohen, Maria Jose Luna, Vadim Y. Bolshakov, Jeffrey Schweitzer, Hyemyung Seo, Kwang Soo Kim, Jin Hyuk Jung, Jisun Kim, Jeffrey H. Kordower, Claudia Lopes, Melissa Feitosa, Pierre Leblanc, Kyungjoon Park, Dabin Hwang, Young Joo Cha, Martin H. Teicher, Sek Won Kong, In-Hee Lee, Sanghyeok Ko, Bob S. Carter, Bin Song, Nayeon Lee
Publikováno v:
J Clin Invest
Parkinson's disease (PD) is a neurodegenerative disorder associated with loss of striatal dopamine, secondary to degeneration of midbrain dopamine (mDA) neurons in the substantia nigra, rendering cell transplantation a promising therapeutic strategy.
Autor:
Chun-Hyung Kim, Hye Min Park, Xue-Wei Liu, Choong Hwan Lee, Bin Song, Sungwhan F. Oh, CongBao Kang, Sreekanth Rajan, Geraldine W.Y. Goh, Gregory A. Petsko, Aida Serra, Jeha Jeon, Hong Ye, Yongwoo Jang, Serap Beldar, Kah-Leong Lim, Woori Kim, Jun Yeob Yoo, Melissa Feitosa, Ho Sup Yoon, Dabin Hwang, Hui Ting Toh, Yeahan Kim, Kwang-Soo Kim, Julien Lescar
Publikováno v:
Nat Chem Biol
The orphan nuclear receptor Nurr1 is critical for the development, maintenance and protection of midbrain dopaminergic (mDA) neurons. Here we show that prostaglandin E1 (PGE1) and its dehydrated metabolite, PGA1, directly interact with the ligand-bin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd588e0ced5ac7d9716ad1af8cedaca4
https://hdl.handle.net/10356/155280
https://hdl.handle.net/10356/155280
Autor:
Byungkuk Min, Kyuheum Jeon, Myungsun Park, Jung Sun Park, Sangkyun Jeong, Jinhoi Song, Jisun Kim, Yong-Kook Kang, Sunwha Cho, Jeha Jeon, Hyemyung Seo, Seokho Kim
Publikováno v:
Aging (Albany NY)
Expansion of polyglutamine stretch in the huntingtin (HTT) protein is a major cause of Huntington's disease (HD). The polyglutamine part in HTT interacts with various proteins implicated in epigenetic regulation of genes, suggesting that mutant HTT m
Autor:
Young Cha, Taewoo Kim, Jeha Jeon, Yongwoo Jang, Patrick B. Kim, Claudia Lopes, Pierre Leblanc, Bruce M. Cohen, Kwang-Soo Kim
Publikováno v:
Cell reports
SUMMARY During somatic reprogramming, cellular energy metabolism fundamentally switches from predominantly mitochondrial oxidative phosphorylation toward glycolysis. This metabolic reprogramming, also called the Warburg effect, is critical for the in
Publikováno v:
Molecular Neurobiology. 53:2276-2286
Huntington’s disease (HD) is a movement disorder characterized by the early selective degeneration of striatum. For motor control, the striatum receives excitatory inputs from multiple brain regions and projects the information to other basal gangl
Publikováno v:
Neurochemistry International. 69:35-40
Lipopolysaccharide (LPS) administration may be used to induce an in vivo model for neuroinflammation or neurodegeneration. We examined the regional distribution of inflammatory markers induced by LPS in the brain of young mice. Criteria for inflammat
Autor:
In Gyu Kim, Insuk So, Min Jueng Kang, Hyemyung Seo, Kyu Pil Lee, Kotdaji Ha, Jihoon Jang, Jeha Jeon, Misun Kwak, Ju Hong Jeon, Hoon Ryu, Chansik Hong, Eugene C. Yi, Eui Man Jeong, Jongyun Myeong, Yu Jin Hwang
Publikováno v:
Brain : a journal of neurology. 138(Pt 10)
Aberrant glutathione or Ca(2+) homeostasis due to oxidative stress is associated with the pathogenesis of neurodegenerative disorders. The Ca(2+)-permeable transient receptor potential cation (TRPC) channel is predominantly expressed in the brain, wh