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Optimisation of the detection of bacterial proteases using adsorbed immunoglobulins as universal substrates

Autor: Abuknesha, Ram A., Jeganathan, Fiona, Wildeboer, Dirk, Price, Robert G.

Publikováno v: In Talanta 2010 81(4):1237-1244

Characterization of bacterial proteases with a panel of fluorescent peptide substrates

Autor: Wildeboer, Dirk, Jeganathan, Fiona, Price, Robert G., Abuknesha, Ramadan A.

Publikováno v: In Analytical Biochemistry 2009 384(2):321-328

8-substituted pyrido[3,4-d]pyrimidin-4(3H)-one derivatives as potent, cell permeable, KDM4 (JMJD2) and KDM5 (JARID1) histone lysine demethylase inhibitors

Autor: Bavetsias, Vassilios, Lanigan, Rachel M., Ruda, Gian Filippo, Atrash, Butrus, McLaughlin, Mark G., Tumber, Anthony, Mok, N. Yi, Le Bihan, Yann-Vaï, Dempster, Sally, Boxall, Katherine J., Jeganathan, Fiona, Hatch, Stephanie B., Savitsky, Pavel, Velupillai, Srikannathasan, Krojer, Tobias, England, Katherine S., Sejberg, Jimmy, Thai, Ching, Donovan, Adam, Pal, Akos, Scozzafava, Giuseppe, Bennett, James M., Kawamura, Akane, Johansson, Catrine, Szykowska, Aleksandra, Gileadi, Carina, Burgess-Brown, Nicola A., von Delft, Frank, Oppermann, Udo, Walters, Zoe, Shipley, Janet, Raynaud, Florence I., Westaway, Susan M., Prinjha, Rab K., Fedorov, Oleg, Burke, Rosemary, Schofield, Christopher J., Westwood, Isaac M., Bountra, Chas, Müller, Susanne, van Montfort, Rob L. M., Brennan, Paul E., Blagg, Julian

Publikováno v: 'Journal of Medicinal Chemistry ', vol: 59, pages: 1388-1409 (2016)
Bavetsias, V, Lanigan, R M, Ruda, G F, Atrash, B, McLaughlin, M G, Tumber, A, Mok, N Y, Le Bihan, Y V, Dempster, S, Boxall, K J, Jeganathan, F, Hatch, S B, Savitsky, P, Velupillai, S, Krojer, T, England, K S, Sejberg, J, Thai, C, Donovan, A, Pal, A, Scozzafava, G, Bennett, J M, Kawamura, A, Johansson, C, Szykowska, A, Gileadi, C, Burgess-Brown, N A, Von Delft, F, Oppermann, U, Walters, Z, Shipley, J, Raynaud, F I, Westaway, S M, Prinjha, R K, Fedorov, O, Burke, R, Schofield, C J, Westwood, I M, Bountra, C, Müller, S, Van Montfort, R L M, Brennan, P E & Blagg, J 2016, ' 8-substituted pyrido[3,4-d ]pyrimidin-4(3 H )-one derivatives as potent, cell permeable, KDM4 (JMJD2) and KDM5 (JARID1) histone lysine demethylase inhibitors ', Journal of Medicinal Chemistry, vol. 59, no. 4, pp. 1388-1409 . https://doi.org/10.1021/acs.jmedchem.5b01635
Journal of Medicinal Chemistry

We report the discovery of N-substituted 4-(pyridin-2-yl)thiazole-2-amine derivatives and their subsequent optimization, guided by structure-based design, to give 8-(1H-pyrazol-3-yl)pyrido[3,4-d]pyrimidin-4(3H)-ones, a series of potent JmjC histone N

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::bbc47579e6b0a4a1af458967da196c34
https://epn-library.esrf.fr/flora/jsp/index_view_direct_anonymous.jsp?record=doc:PUB_ESRF:43287

Detection of proteases using an immunochemical method with haptenylated–gelatin as a solid-phase substrate.

Autor: Abuknesha, Ramadan A.¹ Ram.abuknesha@kcl.ac.uk, Jeganathan, Fiona¹, DeGroot, Rens², Wildeboer, Dirk¹, Price, Robert G.¹

Publikováno v: Analytical & Bioanalytical Chemistry. Apr2010, Vol. 396 Issue 7, p2547-2558. 12p. 1 Diagram, 3 Charts, 5 Graphs.