Zobrazeno 1 - 2
of 2
pro vyhledávání: '"Jefrey P Ciavarri"'
Autor:
Yu Yang, Christopher Tsu, Michael D. Sintchak, Allison Berger, Lawrence Dick, Khristofer Garcia, Jie Yu, Paul Hales, Yueying Kao, Frank J. Bruzzese, Jefrey P Ciavarri, Jonathan L. Blank, Paul E. Fleming, Erik Kupperman, Jane Liu, Bret Bannerman, Mark Manfredi, Edmund Lee, Michael Fitzgerald
Publikováno v:
Molecular Cancer Therapeutics. 10:C99-C99
Bortezomib (Velcade®) is a proteasome inhibitor that has been approved by the U.S. Food and Drug Administration for the treatment of patients with multiple myeloma or relapsed mantle cell lymphoma. It is currently available in more than 90 countries
Autor:
Deborah J. Kuhn, Zhigen Hu, Peter M. Voorhees, Frank J. Bruzzese, Robert Z. Orlowski, John S. Strader, Jefrey P Ciavarri, Qing Chen
Publikováno v:
Blood. 108:3458-3458
Introduction: The proteasome is a large (~2.5 MDa), ATP-dependent, intracellular protease responsible for degrading ubiquitinated proteins as part of the ubiquitin-proteasome pathway. The immunoproteasome is a unique proteasomal variant with distinct