Alternative substitutions of N332 in HIV-1AD8 gp120 differentially affect envelope glycoprotein function and viral sensitivity to broadly neutralizing antibodies targeting the V3-glycan

Autor: Jeffy Jeffy, Durgadevi Parthasarathy, Shamim Ahmed, Héctor Cervera-Benet, Ulahn Xiong, Miranda Harris, Dmitriy Mazurov, Stephanie Pickthorn, Alon Herschhorn

Publikováno v: mBio, Vol 15, Iss 4 (2024)

ABSTRACTThe envelope glycoprotein (Env) trimer on the surface of human immunodeficiency virus type I (HIV-1) mediates viral entry into host CD4+ T cells and is the sole target of neutralizing antibodies. Broadly neutralizing antibodies (bnAbs) that t

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Alternative substitutions of N332 in HIV-1 AD8 gp120 differentially affect envelope glycoprotein function and viral sensitivity to broadly neutralizing antibodies targeting the V3-glycan.

Autor: Jeffy J; Division of Infectious Diseases and International Medicine, Department of Medicine, University of Minnesota, Minneapolis, Minnesota 55455, USA., Parthasarathy D; Division of Infectious Diseases and International Medicine, Department of Medicine, University of Minnesota, Minneapolis, Minnesota 55455, USA., Ahmed S; Division of Infectious Diseases and International Medicine, Department of Medicine, University of Minnesota, Minneapolis, Minnesota 55455, USA., Cervera-Benet H; Division of Infectious Diseases and International Medicine, Department of Medicine, University of Minnesota, Minneapolis, Minnesota 55455, USA., Xiong U; Division of Infectious Diseases and International Medicine, Department of Medicine, University of Minnesota, Minneapolis, Minnesota 55455, USA., Harris M; Division of Infectious Diseases and International Medicine, Department of Medicine, University of Minnesota, Minneapolis, Minnesota 55455, USA., Mazurov D; Division of Infectious Diseases and International Medicine, Department of Medicine, University of Minnesota, Minneapolis, Minnesota 55455, USA., Pickthorn S; Division of Infectious Diseases and International Medicine, Department of Medicine, University of Minnesota, Minneapolis, Minnesota 55455, USA., Herschhorn A; Division of Infectious Diseases and International Medicine, Department of Medicine, University of Minnesota, Minneapolis, Minnesota 55455, USA.; Institute for Molecular Virology, University of Minnesota, Minneapolis, MN 55455, USA.; Institute of Engineering and Medicine, University of Minnesota, Minneapolis, MN 55455, USA.; Center of Genomic Engineering, University of Minnesota, Minneapolis, MN 55455, USA.; Microbiology, Immunology, and Cancer Biology Graduate Program, the College of Veterinary Medicine Graduate Program, and Molecular Pharmacology and Therapeutics Graduate Program, University of Minnesota, Minneapolis, Minnesota 55455, USA.

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2023 Nov 21. Date of Electronic Publication: 2023 Nov 21.