Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Jeffry Shearer"'
Autor:
Demetrius Matassov, Lisa Evans DeWald, Stefan Hamm, Rebecca M. Nowak, Cheryl S. Gerardi, Theresa E. Latham, Rong Xu, Amara Luckay, Tracy Chen, Marc Tremblay, Jeffry Shearer, Melissa Wynn, John H. Eldridge, Kelly Warfield, Kevin Spurgers
Publikováno v:
Vaccines, Vol 12, Iss 8, p 858 (2024)
There are currently no prophylactic vaccines licensed to protect against Lassa fever caused by Lassa virus (LASV) infection. The Emergent BioSolutions (EBS) vaccine candidate, EBS-LASV, is being developed for the prevention of Lassa fever. EBS-LASV i
Externí odkaz:
https://doaj.org/article/5ac6e9310ddd44a58999bee90fd7b27a
Autor:
Jeffry, Shearer, Gary, Wolfe, Mansoora, Khaliq, Brian, Kaufman, Aruna, Sampath, Kelly L, Warfield, Urban, Ramstedt, Anthony, Treston
Publikováno v:
Reproductive Toxicology. 114:9-21
UV-4 (N-(9-methoxynonyl)-1-deoxynojirimycin) is a host-targeted antiviral agent, which targets mammalian proteins (endoplasmic reticulum glucosidases) rather than virally encoded proteins. This mechanism confers both broad-spectrum activity and low p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dbce7b4440487794c9728257110cb2de
https://doi.org/10.1016/j.reprotox.2022.09.007
https://doi.org/10.1016/j.reprotox.2022.09.007
Autor:
Jeffry Shearer, Gary Wolfe, Aruna Sampath, Kelly L Warfield, Brian Kaufman, Urban Ramstedt, Anthony Treston
Publikováno v:
Int J Toxicol
UV-4 (N-(9-methoxynonyl)-1-deoxynojirimycin) is a broad-spectrum antiviral drug candidate with demonstrated activity in vitro and in vivo against multiple, diverse viruses. Nonclinical safety pharmacology studies were conducted to support the filing
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::240b9d52428e2736e80949c581e2f5b6
https://doi.org/10.1177/10915818211072842
https://doi.org/10.1177/10915818211072842
Autor:
Jeffry Shearer, Gary Wolfe, Aruna Sampath, Kelly L. Warfield, Brian Kaufman, Urban Ramstedt, Anthony Treston
Publikováno v:
International journal of toxicology. 41(3)
The iminosugar UV-4 is a broad-spectrum antiviral drug candidate with activity in vitro and in vivo against multiple, diverse viruses. The toxicological profile of UV-4, dosed as the hydrochloride salt, was evaluated in single-dose and repeat-dose or
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db511470cf41badacb29a2105d7b27de
https://pubmed.ncbi.nlm.nih.gov/35426748
https://pubmed.ncbi.nlm.nih.gov/35426748
Autor:
Jeffry Shearer, Michelle Vassar, Nancy Niemuth, William Swiderski, H. Holley, Karen Metcalfe, Mary Hart
Publikováno v:
The Journal of Immunology. 184:46.5-46.5
Efficacy of the Recombinant Botulinum Vaccine A/B (rBV A/B) against lethal intoxication with botulinum neurotoxin complex (BoNT) cannot be evaluated directly in humans; therefore, efficacy will be based on meeting the requirements of the FDA Animal R
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::719b9a59281804c128a2f272a44895ab
https://doi.org/10.4049/jimmunol.184.supp.46.5
https://doi.org/10.4049/jimmunol.184.supp.46.5
Autor:
Michael D. Caldwell, Jeffry Shearer, William L. Henry, Balduino Mastrofrancesco, Jorge E. Albina, Allen Morris
Publikováno v:
Journal of Surgical Research. 37:63-68
Classically, increased lactate production in wounded tissue is ascribed to anaerobic glycolysis although its oxygen consumption has been found to be similar to normal tissue. This apparent inconsistency was studied in a standardized isolated perfused
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36e0a65dede227313c53c96d4b6d6c73
https://doi.org/10.1016/0022-4804(84)90162-8
https://doi.org/10.1016/0022-4804(84)90162-8
Autor:
Michael D. Caldwell, Allen Morris, Jeffry Shearer, Balduino Mastrofrancesco, William L. Henry
Publikováno v:
The Journal of surgical research. 38(4)
A marked cellular infiltrate accompanies wounding. The phagocytic and bacteriocidal activities of this infiltrate require increased substrate and O 2 consumption. This rapid utilization of available oxygen and substrates could jeopardize an already c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7500db36b091535d2193f6dc7e5f225a
https://pubmed.ncbi.nlm.nih.gov/3999732
https://pubmed.ncbi.nlm.nih.gov/3999732
Autor:
P. A. King, Balduino Mastrofrancesco, Michael D. Caldwell, Jeffry Shearer, L. Goldstein, William L. Henry, Jorge E. Albina
Publikováno v:
The American journal of physiology. 252(1 Pt 1)
Wounding with lambda-carrageenan results in a marked decrease in the intracellular-free glutamine content of rat skeletal muscle. The potential mechanisms for this finding, including alterations in glutamine release, glutamine utilization, and glutam
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83828f53cf501fd1276c36a374f68467
https://pubmed.ncbi.nlm.nih.gov/2880509
https://pubmed.ncbi.nlm.nih.gov/2880509
Autor:
Jeffry Shearer, Gordon P. Buzby, Elizabeth E. Miller, Lon O. Crosby, James L. Mullen, Michael D. Caldwell
Publikováno v:
JPEN. Journal of parenteral and enteral nutrition. 7(2)
Alterations in metabolism in the tumor-bearing host can be explained by: 1) alterations of metabolic processes in the tumor itself, and/or 2) tumor effects on host metabolism. Tumor effects on host liver metabolism were studied using an isolated perf
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed54e6f2f97ef5cd24407034be138193
https://pubmed.ncbi.nlm.nih.gov/6682907
https://pubmed.ncbi.nlm.nih.gov/6682907