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pro vyhledávání: '"Jeffry Kimo Curtis"'
Autor:
Jeffry Kimo Curtis, Julie Lougheed, Stefan Engst, Peiwen Yu, Anagha Abhijit Joshi, Elena S. Koltun, Csaba J. Peto, Neel Kumar Anand, Jean-Claire Limun Manalo, Stuart Johnston, Steven Charles Defina, Abigail R. Kennedy, Naing Aay, Kenneth D. Rice, Larisa Dubenko, Tsze H. Tsang, Jean-Francois Martini, Simona Costanzo, John M. Nuss, Angie I. Kim, Owen Joseph Bowles, Joerg Bussenius, Charles M. Blazey
Publikováno v:
ACS Medicinal Chemistry Letters. 3:416-421
The ERK/MAP kinase cascade is a key mechanism subject to dysregulation in cancer and is constitutively activated or highly upregulated in many tumor types. Mutations associated with upstream pathway components RAS and Raf occur frequently and contrib