Výsledky vyhledávání - "Jeffry D. Watkins"

Autor: Jeffry D. Watkins, Derrick R. Witcher, Ying Tang, Victor J. Wroblewski, Amita Datta-Mannan

Publikováno v: Journal of Biological Chemistry. 282:1709-1717

The neonatal Fc receptor (FcRn) plays a critical role in regulating IgG homeostasis in vivo. There are mixed reports on whether modification of the interaction with FcRn can be used as an engineering strategy to improve the pharmacokinetic and pharma

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::491cd173caafb65e06614433cc81892e
https://doi.org/10.1074/jbc.m607161200

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Gene Transfer of Cocaine Hydrolase Suppresses Cardiovascular Responses to Cocaine in Rats

Autor: Nan Sui, Stephen Brimijoin, Jeffry D. Watkins, James D. Pancook, Elena Atanasova, Yang Gao

Publikováno v: Molecular Pharmacology. 67:204-211

We previously found that injection of a cocaine hydrolase (CocE) engineered from human butyrylcholinesterase will transiently accelerate cocaine metabolism in rats while reducing physiological and behavioral responses. To investigate more extended th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dda3e57158be19587abbe7b5e742340f
https://doi.org/10.1124/mol.104.006924

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Expanding the clinical utility of therapeutic proteins: activated protein C variants with improved pharmacological properties

Autor: Alain Philippe Vasserot, Jeffry D. Watkins

Publikováno v: Trends in Pharmacological Sciences. 24:501-504

Proteins have emerged as viable treatments for a broad range of diseases, and their therapeutic applications have expanded considerably during the past decade. Although most biologics are administered in their native form to patients, engineering eff

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c37bf21ba5944351b1eb636ea98e991
https://doi.org/10.1016/j.tips.2003.08.004

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Optimization of protein therapeutics by directed evolution

Autor: Craig Duane Dickinson, William D. Huse, Ying Tang, Jeffry D. Watkins, Alain Philippe Vasserot, Keith S Manchester

Publikováno v: Drug Discovery Today. 8:118-126

Directed evolution is a broadly applicable technology platform that is ideally suited to address the need for protein optimization and to fully exploit the therapeutic potential of biologics. The approach takes advantage of the remarkable structural

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00a861ecf2a0e34330b655262e3baf8f
https://doi.org/10.1016/s1359-6446(02)02590-4

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Stepwisein vitroaffinity maturation of Vitaxin, an αvβ3-specific humanized mAb

Autor: Heidi Smith, Herren Wu, Ying Nie, Bruce A. Lee, Mary E. Hensler, William D. Huse, Jeffry D. Watkins, Gregory Beuerlein

Publikováno v: Proceedings of the National Academy of Sciences. 95:6037-6042

A protein engineering strategy based on efficient and focused mutagenesis implemented by codon-based mutagenesis was developed. Vitaxin, a humanized version of the antiangiogenic antibody LM609 directed against a conformational epitope of the αvβ3i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0c39f5e19f788cca3b043535e3f8a87e
https://doi.org/10.1073/pnas.95.11.6037

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Determination of the Relative Affinities of Antibody Fragments Expressed inEscherichia coliby Enzyme-Linked Immunosorbent Assay

Autor: Paul R. McFadden, Scott M. Glaser, Jeffry D. Watkins, Gerlinde Pecht, Gregory Beuerlein, William D. Huse

Publikováno v: Analytical Biochemistry. 253:37-45

We have previously utilized an M13 phage expression system and codon-based mutagenesis to increase the avidity of the tumor-specific antibody, BR96, 65-fold (Yelton et al., 1995, J. Immunol. 155, 1994-2004). Mutants with improved affinity were identi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24358a6fc1347e5fd6e958d25e567720
https://doi.org/10.1006/abio.1997.2335

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Humanized IgG1 variants with differential binding properties to the neonatal Fc receptor: relationship to pharmacokinetics in mice and primates

Autor: Weidong Jiang, Victor J. Wroblewski, Derrick R. Witcher, Ying Tang, Jeffry D. Watkins, Amita Datta-Mannan

Publikováno v: Drug metabolism and disposition: the biological fate of chemicals. 35(1)

It is well established that the neonatal Fc receptor (FcRn) plays a critical role in regulating IgG homeostasis in vivo. As such, modification of the interaction of IgG with FcRn has been the focus of protein-engineering strategies designed to genera

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::281085e407f9cb4b19c3098b66f3e078
https://pubmed.ncbi.nlm.nih.gov/17050651

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