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Discovery, characterization and biological evaluation of a novel (R)-4,4-difluoropiperidine scaffold as dopamine receptor 4 (D4R) antagonists

Autor: Jeffries, Daniel E., Witt, Jonathan O., McCollum, Andrea L., Temple, Kayla J., Hurtado, Miguel A., Harp, Joel M., Blobaum, Anna L., Lindsley, Craig W., Hopkins, Corey R.

Publikováno v: In Bioorganic & Medicinal Chemistry Letters 1 December 2016 26(23):5757-5764

RedH and PigC Catalyze the Biosynthesis of Hybrubins via Phosphorylation of 4'-Methoxy-2,2'=-Bipyrrole-5'-Carbaldehyde.

Autor: Qingshan Long¹, Jeffries, Daniel E.², Shuangjun Lin¹, Xuefei Chen¹, Weijun He¹, Yemin Wang¹, Zixin Deng¹, Lindsley, Craig W.^2,3, Meifeng Tao¹ tao_meifeng@sjtu.edu.cn

Publikováno v: Applied & Environmental Microbiology. 1/15/2020, Vol. 86 Issue 2, p1-11. 11p.

Discovery of VU6015929: A Selective Discoidin Domain Receptor 1/2 (DDR1/2) Inhibitor to Explore the Role of DDR1 in Antifibrotic Therapy.

Autor: Jeffries DE; Department of Chemistry, Vanderbilt University, Nashville, Tennessee 37232, United States., Borza CM; Department of Medicine, Division of Nephrology, Vanderbilt University, Nashville, Tennessee 37232, United States., Blobaum AL; Department of Pharmacology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, United States.; Vanderbilt Center for Neuroscience Drug Discovery, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, United States., Pozzi A; Department of Medicine, Division of Nephrology, Vanderbilt University, Nashville, Tennessee 37232, United States.; Veterans Affairs Medical Center, Nashville, Nashville, Tennessee 37232, United States., Lindsley CW; Department of Chemistry, Vanderbilt University, Nashville, Tennessee 37232, United States.; Department of Pharmacology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, United States.; Vanderbilt Center for Neuroscience Drug Discovery, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, United States.

Publikováno v: ACS medicinal chemistry letters [ACS Med Chem Lett] 2019 Nov 25; Vol. 11 (1), pp. 29-33. Date of Electronic Publication: 2019 Nov 25 (Print Publication: 2020).