Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Jeffri S, Retamal"'
Autor:
David Bravo, Katherine Zepeda-Morales, Carola J. Maturana, Jeffri S. Retamal, Alejandro Hernández, Teresa Pelissier, Rafael Barra, Patricio Sáez-Briones, Héctor Burgos, Luis Constandil
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 12, p 6705 (2022)
Pannexin 1 (Panx1) is involved in the spinal central sensitization process in rats with neuropathic pain, but its interaction with well-known, pain-related, ligand-dependent receptors, such as NMDA receptors (NMDAR) and P2X7 purinoceptors (P2X7R), re
Externí odkaz:
https://doaj.org/article/bbb8be88c0b74bb1b3018f325931cf79
Autor:
Jeffri S. Retamal, Paulina D. Ramírez-García, Priyank A. Shenoy, Daniel P. Poole, Nicholas A. Veldhuis
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 12 (2019)
Peripheral and central neurons in the pain pathway are well equipped to detect and respond to extracellular stimuli such as pro-inflammatory mediators and neurotransmitters through the cell surface expression of receptors that can mediate rapid intra
Externí odkaz:
https://doaj.org/article/6c4549998de54b78bfc2d6ea2bed3f2a
Autor:
Sadia Alvi, Daniel P. Poole, Peter McIntyre, Scott Peng, Arisbel B. Gondin, Paulina D. Ramírez-García, Pradeep Rajasekhar, Larissa K. Dill, Simona E. Carbone, Thomas P. Davis, Felix Bennetts, Jeffri S. Retamal, Megan S. Grace, Juhura G. Almazi, Nicholas A. Veldhuis, Nigel W. Bunnett
Publikováno v:
Laboratory Investigation; a Journal of Technical Methods and Pathology
Endothelial and epithelial cells form physical barriers that modulate the exchange of fluid and molecules. The integrity of these barriers can be influenced by signaling through G protein-coupled receptors (GPCRs) and ion channels. Serotonin (5-HT) i
Autor:
Rocco Latorre, Alan Hegron, Chloe J. Peach, Shavonne Teng, Raquel Tonello, Jeffri S. Retamal, Rafael Klein-Cloud, Diana Bok, Dane D. Jensen, Lena Gottesman-Katz, Jeanette Rientjes, Nicholas A. Veldhuis, Daniel P. Poole, Alex R. B. Thomsen, Brian L. Schmidt, Charalabos H. Pothoulakis, Carl Rankin, Ying Xie, Hon Wai Koon, Nigel W. Bunnett
Publikováno v:
Proceedings of the National Academy of Sciences. 119
G protein–coupled receptors (GPCRs) regulate many pathophysiological processes and are major therapeutic targets. The impact of disease on the subcellular distribution and function of GPCRs is poorly understood. We investigated trafficking and sign
Autor:
Rocco, Latorre, Alan, Hegron, Chloe J, Peach, Shavonne, Teng, Raquel, Tonello, Jeffri S, Retamal, Rafael, Klein-Cloud, Diana, Bok, Dane D, Jensen, Lena, Gottesman-Katz, Jeanette, Rientjes, Nicholas A, Veldhuis, Daniel P, Poole, Brian L, Schmidt, Charalabos H, Pothoulakis, Carl, Rankin, Ying, Xie, Hon Wai, Koon, Nigel W, Bunnett
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 119(6)
G protein-coupled receptors (GPCRs) regulate many pathophysiological processes and are major therapeutic targets. The impact of disease on the subcellular distribution and function of GPCRs is poorly understood. We investigated trafficking and signal
Autor:
Rocco Latorre, Paulina D. Ramírez-Garcia, Alan Hegron, James L. Grace, Jeffri S. Retamal, Priyank Shenoy, Mai Tran, Luigi Aurelio, Bernard Flynn, Daniel P. Poole, Rafael Klein-Cloud, Dane D. Jensen, Thomas P. Davis, Brian L. Schmidt, John F. Quinn, Michael R. Whittaker, Nicholas A. Veldhuis, Nigel W. Bunnett
Publikováno v:
Biomaterials
Soft polymer nanoparticles designed to disassemble and release an antagonist of the neurokinin 1 receptor (NK(1)R) in endosomes provide efficacious yet transient relief from chronic pain. These micellar nanoparticles are unstable and rapidly release
Autor:
Thomas P. Davis, Paulina D. Ramírez-García, Rocco Latorre, Alan Hegron, Matilde Marini, Daniel Souza Monteiro de Araujo, Julia Ding, Brian P. Schmidt, Romina Nassini, Dane D. Jensen, Mustafa Titiz, Michael R. Whittaker, Pierangelo Geppetti, Nigel W. Bunnett, Alessandro Innocenti, Jeffri S. Retamal, Francesco De Logu, Lorenzo Landini, Nicholas A. Veldhuis
Efficacy of monoclonal antibodies against calcitonin gene-related peptide (CGRP) or its receptor (calcitonin receptor-like receptor/receptor activity modifying protein-1, CLR/RAMP1) implicates peripherally-released CGRP in migraine pain. However, the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::efe1d8c0f465f9e6d5ec91e7ca7f0355
https://doi.org/10.21203/rs.3.rs-758153/v1
https://doi.org/10.21203/rs.3.rs-758153/v1
Autor:
P.A. Shenoy, Michelle L. Halls, Luigi Aurelio, Tim Quach, Joshua W. Conner, Quynh N. Mai, Stephen J. Hill, Thomas P. Davis, Meritxell Canals, Christopher J.H. Porter, Nigel W. Bunnett, Arisbel B. Gondin, Cameron J. Nowell, Holly R. Yeatman, Bim Graham, Nicholas A. Veldhuis, Jeffri S. Retamal, Daniel P. Poole, Stephen J. Briddon
Publikováno v:
The Journal of Biological Chemistry
G-protein-coupled receptors (GPCRs) are traditionally known for signaling at the plasma membrane, but they can also signal from endosomes after internalization to control important pathophysiological processes. In spinal neurons, sustained endosomal
Autor:
Daniel P. Poole, Thomas P. Davis, William Darby, Tara Tigani, Nigel W. Bunnett, Scott Peng, Peter McIntyre, Larissa K. Dill, Nicholas A. Veldhuis, Jeffri S. Retamal, Arisbel B. Gondin, Simona E. Carbone, Fe C. Abogadie, Megan S. Grace
Publikováno v:
Lab Invest
Endothelial barrier disruption is a hallmark of tissue injury, edema, and inflammation. Vascular endothelial cells express the G protein-coupled receptor (GPCR) protease acctivated receptor 1 (PAR1) and the ion channel transient receptor potential va
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::364e5279eaaa0ad30092b48ecc6e66ed
https://europepmc.org/articles/PMC10080476/
https://europepmc.org/articles/PMC10080476/
Autor:
Song Y. Khor, Matthew J. Sykes, Nigel W. Bunnett, Thomas P. Davis, Michael R. Whittaker, Wendy L. Imlach, Nicholas A. Veldhuis, Dane D. Jensen, Tina Marie Lieu, Brian L. Schmidt, Teresa Pelissier, Nghia P. Truong, Louis M. Layani, John F. Quinn, Chris Lumb, P.A. Shenoy, Nicole N. Scheff, Paulina D. Ramírez-García, Quynh N. Mai, Rocco Latorre, Cameron J. Nowell, Daniel P. Poole, Gregory D. Stewart, Luis Constandil, Jeffri S. Retamal
Publikováno v:
Nat Nanotechnol
Nanoparticle-mediated drug delivery is especially useful for targets within endosomes because of the endosomal transport mechanisms of many nanomedicines within cells. Here, we report the design of a pH-responsive, soft polymeric nanoparticle for the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72f2498ad67b5820322d6fc1a65c6e37
https://europepmc.org/articles/PMC7765343/
https://europepmc.org/articles/PMC7765343/