Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Jeffrey Zurita"'
Autor:
Jeremy R. Duvall, Raghida A. Bukhalid, Naniye M. Cetinbas, Kalli C. Catcott, Kelly Lancaster, Keith W. Bentley, Suzanna Clark, Susan Clardy, Scott D. Collins, Anouk Dirksen, Elizabeth Ditty, Bingfan Du, Eugene W. Kelleher, Travis Monnell, Marina Protopopova, Caitlin Routhier, Cheri Stevenson, Elena Ter-Ovanesyan, Joshua D. Thomas, Alex Uttard, Jason Wang, Phonphimon Wongthida, Ling Xu, Annika Yau, Jeffrey Zurita, Dorin Toader, Marc Damelin, Timothy B. Lowinger
Publikováno v:
Cancer Research. 82:3503-3503
We present here a novel therapeutic agent, XMT-2056, that results in robust anti-tumor activity mediated by an immune response through targeted delivery of a STING agonist to the tumor microenvironment. By leveraging an antibody-drug conjugate (ADC)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0104b7acc0fcee8f20a6655acfc9a034
https://doi.org/10.1158/1538-7445.am2022-3503
https://doi.org/10.1158/1538-7445.am2022-3503
Autor:
Richard L. Frock, Frederick W. Alt, Jeffrey Zurita, Vipul Kumar, Sherry G. Lin, Jiangman Lou, Josefin Kenrick, Cristian Boboila, Adam Yongxin Ye, Marie Le Bouteiller, Jianqiao Hu, Zhuoyi Liang
Publikováno v:
Proc Natl Acad Sci U S A
Classical nonhomologous end joining (C-NHEJ) repairs DNA double-strand breaks (DSBs) throughout interphase but predominates in G1 phase when homologous recombination is unavailable. Complexes containing the Ku70/80 (“Ku”) and XRCC4/ligase IV (Lig
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d6075287bd3340bd8e7d039986af43f
https://doi.org/10.1073/pnas.2103630118
https://doi.org/10.1073/pnas.2103630118
Autor:
Yuxiang Zhang, Pei-Chi Wei, Anne Devorak, Frederick W. Alt, Aseda Tena, Nia Kyritsis, Jeffrey Zurita
Publikováno v:
Proc Natl Acad Sci U S A
Mild replication stress enhances appearance of dozens of robust recurrent genomic break clusters, termed RDCs, in cultured primary mouse neural stem and progenitor cells (NSPCs). Robust RDCs occur within genes (“RDC-genes”) that are long and have
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4efc5251e55ba0713c4da0bf20851f7f
https://europepmc.org/articles/PMC7229678/
https://europepmc.org/articles/PMC7229678/
Autor:
Kalli C. Catcott, Susan Clardy, Jack Sadowsky, Rebecca K. Rowntree, Naniye Malli Centibas, Ling Xu, Andy Polson, Kenneth Avocetien, Tyler Carter, Mark Nazzaro, Dokyong \\'DK\\' Kim, Thomas H. Pillow, Neelie Zacharias, Cong Wu, Jeffrey Zurita, Elizabeth Ditty, Stephen Bradley, Alex Uttard, Bingfan Du, William S. Sawyer, Doug Leipold, Gail Lewis Phillips, LiuLiang Qin, Kelly Slocum, Geoffrey Del Rosario, Ginny Li, Shang-Fan Yu, David Lee, Radha Iyengar, Marc Damelin, Dorin Toader, Timothy B. Lowinger
Publikováno v:
Molecular Cancer Therapeutics. 20:P167-P167
Key defining attributes of an antibody-drug conjugate (ADC) include the choice of targeting antibody, linker, and the drug-to-antibody ratio (DAR). The choice of DAR, within the constraints of acceptable physicochemical properties for the given platf
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::935b7e76f6213d4a5e30f27ebae7723c
https://doi.org/10.1158/1535-7163.targ-21-p167
https://doi.org/10.1158/1535-7163.targ-21-p167
Autor:
Kelly Slocum, Rebecca Mosher, Jeffrey Zurita, Kenneth Avocetien, Joshua D. Thomas, Timothy B. Lowinger, Kalli C. Catcott, Susan M. Clardy, Marc Damelin, Jeremy R. Duvall, Marina Protopopova, Naniye Malli Cetinbas, Scott D. Collins, Ling Xu, Keith W. Bentley, Brian D. Jones, Elena Ter-Ovanesyan, Eugene W. Kelleher, Timothy Eitas, Raghida A. Bukhalid, Dorin Toader, Liping Yang, Travis Monnell, Elizabeth Ditty, LiuLiang Qin, Winnie Lee, Pamela Shaw, Phonphimon Wongthida, Stephen Bradley
Publikováno v:
Cancer Research. 81:1738-1738
STING pathway agonism has emerged as a potential therapeutic mechanism to stimulate an innate anti-tumor immune response. However, the systemic administration of a free STING agonist may be limited by toxicity, and broad biodistribution may not be id
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6dd4080a98b5a36ec4e0e10f0f535b90
https://doi.org/10.1158/1538-7445.am2021-1738
https://doi.org/10.1158/1538-7445.am2021-1738
Autor:
Scott D. Collins, Kelly Slocum, Jason K. Wang, Dorin Toader, Ling Xu, Elizabeth Ditty, Chen-Ni Chin, Anouk Dirksen, Marc Damelin, Steven Vonderfecht, Rebecca Mosher, Dokyong Kim, Jeffrey Zurita, Susan M. Clardy, Kenneth Avocetien, Ronald Eydelloth, Timothy B. Lowinger, LiuLiang Qin, Bingfan Du, Steven Bradley, Shawn P. Fessler, Phonphimon Wongthida, Alex Uttard, Elena Ter-Ovanesyen
Publikováno v:
Cancer Research. 81:907-907
XMT-1660 is a novel Dolasynthen-based antibody drug conjugate carrying a DolaLock payload with controlled bystander effect and targeting B7-H4, a tumor antigen that is broadly expressed on the cell surface in breast, ovarian and endometrial cancers.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8d2807e2ea7c8be1c11fb15f3c7dc8f0
https://doi.org/10.1158/1538-7445.am2021-907
https://doi.org/10.1158/1538-7445.am2021-907
Autor:
Hongli Hu, Muhammad S. Shamim, Xuefei Zhang, Zhaoqing Ba, Yu Zhang, Aviva Presser Aiden, Zhuoyi Liang, Nia Kyritsis, Jiangman Lou, Erez Lieberman Aiden, Jeffrey Zurita, Frederick W. Alt, Edward W. Dring
Publikováno v:
Nature
The RAG endonuclease initiates Igh V(D)J assembly in B cell progenitors by joining D segments to JH segments, before joining upstream VH segments to DJH intermediates1. In mouse progenitor B cells, the CTCF-binding element (CBE)-anchored chromatin lo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e310c7d649e9bf2a1eaf312aad851e0d
https://pubmed.ncbi.nlm.nih.gov/31719691
https://pubmed.ncbi.nlm.nih.gov/31719691
Autor:
Shawn Fessler, Anouk Dirksen, Scott D. Collins, Ling Xu, Winnie Lee, Jason Wang, Ron Eydelloth, Elena Ter-Ovanesyen, Jeffrey Zurita, Elizabeth Ditty, Barrett Nehilla, Susan Clardy, Tyler Carter, Kenneth Avocetien, Mark Nazzaro, Nam Le, Kalli C. Catcott, Alex Uttard, Bingfan Du, Chen-Ni Chin, Rebecca Mosher, Kelly Slocum, Liuliang Qin, David Lee, Dorin Toader, Marc Damelin, Timothy B. Lowinger
Publikováno v:
Cancer Research. 80:2894-2894
The Dolasynthen platform incorporates the highly potent anti-mitotic agent auristatin F-HPA (AF-HPA), with its associated DolaLock mechanism of controlled bystander effect, and enables the synthesis of antibody-drug conjugates (ADCs) with precise con
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8d13a6293b254a8a5ceb2133d5934aa3
https://doi.org/10.1158/1538-7445.am2020-2894
https://doi.org/10.1158/1538-7445.am2020-2894
Autor:
Kalli C. Catcott, Kelly Slocum, Marina Protopopova, Liping Yang, Joshua D. Thomas, Mark Nazzaro, Scott D. Collins, Chen-Ni Chin, Dorin Toader, LiuLiang Qin, Rebecca Mosher, Ling Xu, Jeffrey Zurita, Kenneth Avocetien, Tyler Carter, Raghida A. Bukhalid, Elena Ter-Ovanesyan, Keith W. Bentley, Marc Damelin, Jeremy R. Duvall, Naniye Malli Cetinbas, Timothy Eitas, Brian D. Jones, Stephen Bradley, Pamela Shaw, Susan M. Clardy, Timothy B. Lowinger, Eugene W. Kelleher
Publikováno v:
Cancer Research. 80:6706-6706
STING pathway agonism has emerged as a potential therapeutic mechanism to stimulate an innate anti-tumor immune response. While in principle systemic administration of a STING agonist would have many therapeutic benefits, including the delivery of ST
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::eb8874b5832868b1dcd0fa515563fcc7
https://doi.org/10.1158/1538-7445.am2020-6706
https://doi.org/10.1158/1538-7445.am2020-6706
Autor:
Zhou Du, Pei-Chi Wei, Jeffrey Zurita, Bjoern Schwer, Frederick W. Alt, Jennifer Kao, Yuxiang Zhang, Cheng-Sheng Lee
We recently discovered 27 recurrent DNA double-strand break (DSB) clusters (RDCs) in mouse neural stem/progenitor cells (NSPCs). Most RDCs occurred across long, late-replicating RDC genes and were found only after mild inhibition of DNA replication.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a6e21feb068b17cd07753ec8f8d6405
https://europepmc.org/articles/PMC5828622/
https://europepmc.org/articles/PMC5828622/