Zobrazeno 1 - 10
of 123
pro vyhledávání: '"Jeffrey West"'
Autor:
Sadegh Marzban, Sonal Srivastava, Sharon Kartika, Rafael Bravo, Rachel Safriel, Aidan Zarski, Alexander R. A. Anderson, Christine H. Chung, Antonio L. Amelio, Jeffrey West
Publikováno v:
npj Systems Biology and Applications, Vol 10, Iss 1, Pp 1-12 (2024)
Abstract Direct observation of tumor-immune interactions is unlikely in tumors with currently available technology, but computational simulations based on clinical data can provide insight to test hypotheses. It is hypothesized that patterns of colla
Externí odkaz:
https://doaj.org/article/1d33d803ec3e4aebb7843c05d07fd3d5
Autor:
Jeffrey West, Frederika Rentzeperis, Casey Adam, Rafael Bravo, Kimberly A. Luddy, Mark Robertson-Tessi, Alexander R. A. Anderson
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
IntroductionMetabolism plays a complex role in the evolution of cancerous tumors, including inducing a multifaceted effect on the immune system to aid immune escape. Immune escape is, by definition, a collective phenomenon by requiring the presence o
Externí odkaz:
https://doaj.org/article/ebd312f46cc14f4ba2f015ce8bb9125f
Autor:
Jeffrey West, Fred Adler, Jill Gallaher, Maximilian Strobl, Renee Brady-Nicholls, Joel Brown, Mark Roberson-Tessi, Eunjung Kim, Robert Noble, Yannick Viossat, David Basanta, Alexander RA Anderson
Publikováno v:
eLife, Vol 12 (2023)
Adaptive therapy is a dynamic cancer treatment protocol that updates (or ‘adapts’) treatment decisions in anticipation of evolving tumor dynamics. This broad term encompasses many possible dynamic treatment protocols of patient-specific dose modu
Externí odkaz:
https://doaj.org/article/b62d34430d314feaac3412a682a129f5
Autor:
Maximilian A. R. Strobl, Jill Gallaher, Jeffrey West, Mark Robertson-Tessi, Philip K. Maini, Alexander R. A. Anderson
Publikováno v:
Communications Medicine, Vol 2, Iss 1, Pp 1-18 (2022)
Strobl et al. develop an agent-based spatial model of drug resistance in tumour cells under adaptive therapy. Using this model, they investigate how the tumour’s spatial architecture impacts intratumoural competitive dynamics of drug-sensitive vs.
Externí odkaz:
https://doaj.org/article/6398a24b99384ae086f2c9a62bb96631
Autor:
Chandler D. Gatenbee, Ann-Marie Baker, Ryan O. Schenck, Maximilian Strobl, Jeffrey West, Margarida P. Neves, Sara Yakub Hasan, Eszter Lakatos, Pierre Martinez, William C. H. Cross, Marnix Jansen, Manuel Rodriguez-Justo, Christopher J. Whelan, Andrea Sottoriva, Simon Leedham, Mark Robertson-Tessi, Trevor A. Graham, Alexander R. A. Anderson
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
Integration of mathematical modeling, ecological analyses of patient biopsies, and neoantigen heterogeneity suggests recruitment of immunosuppressive cells is key to initializing transformation from adenoma to carcinoma in human colorectal cancer.
Externí odkaz:
https://doaj.org/article/dec007baa85d4e4e91b6bac2af9bca15
Autor:
Jeffrey West, Ryan O. Schenck, Chandler Gatenbee, Mark Robertson-Tessi, Alexander R. A. Anderson
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-9 (2021)
Some cancers occur in spatially constrained tissues such as the mammary gland, and how the morphological features influence the evolution of the cancer is unclear. Here, the authors use mathematical modeling to study the question of competition for s
Externí odkaz:
https://doaj.org/article/34e86c8a277e4ad28a7be94d4546747f
Autor:
Nassim Nicholas Taleb, Jeffrey West
Publikováno v:
Entropy, Vol 25, Iss 2, p 343 (2023)
We extend techniques and learnings about the stochastic properties of nonlinear responses from finance to medicine, particularly oncology, where it can inform dosing and intervention. We define antifragility. We propose uses of risk analysis for medi
Externí odkaz:
https://doaj.org/article/e1c30faf97c049d6855f899f9c8f4b87
Autor:
Jeffrey West Kirkwood
Publikováno v:
MAST, Vol 1, Iss 1, Pp 35-40 (2020)
Externí odkaz:
https://doaj.org/article/7b9bd87927df4e2d84d7f9249f7533d2
Autor:
S. Andrea Wijtenburg, Jeffrey West, Stephanie A. Korenic, Franchesca Kuhney, Frank E. Gaston, Hongji Chen, Laura M. Rowland
Publikováno v:
Frontiers in Psychiatry, Vol 12 (2021)
Schizophrenia is a severe mental illness with visual learning and memory deficits, and reduced long term potentiation (LTP) may underlie these impairments. Recent human fMRI and EEG studies have assessed visual plasticity that was induced with high f
Externí odkaz:
https://doaj.org/article/3cb2e90349544950890804db024677ee
Autor:
Rafael R Bravo, Etienne Baratchart, Jeffrey West, Ryan O Schenck, Anna K Miller, Jill Gallaher, Chandler D Gatenbee, David Basanta, Mark Robertson-Tessi, Alexander R A Anderson
Publikováno v:
PLoS Computational Biology, Vol 16, Iss 3, p e1007635 (2020)
The Hybrid Automata Library (HAL) is a Java Library developed for use in mathematical oncology modeling. It is made of simple, efficient, generic components that can be used to model complex spatial systems. HAL's components can broadly be classified
Externí odkaz:
https://doaj.org/article/8c93f1866b964adca89115876c9b7377