Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Jeffrey W. Streb"'
Publikováno v:
Ultrasound Quarterly. 35:99-102
Hepatic and renal lesions detected during ultrasound examinations frequently require subsequent contrast-enhanced computed tomography (CT) or magnetic resonance imaging (MRI) for characterization, delaying time to imaging diagnosis and increasing ove
Autor:
Jeffrey W Streb, Xiaochun Long, Ting-Hein Lee, Qiang Sun, Chad M Kitchen, Mary A Georger, Orazio J Slivano, William S Blaner, Daniel W Carr, Irwin H Gelman, Joseph M Miano
Publikováno v:
PLoS ONE, Vol 6, Iss 4, p e18538 (2011)
Retinoids are used clinically to treat a number of hyper-proliferative disorders and have been shown in experimental animals to attenuate vascular occlusive diseases, presumably through nuclear receptors bound to retinoic acid response elements (RARE
Externí odkaz:
https://doaj.org/article/140e7afc289a4e2198d80a2ce8f33b11
Publikováno v:
Development. 139:2878-2890
REST is a master repressor of neuronal genes; however, whether it has any role during nervous system development remains largely unknown. Here, we analyzed systematically the role of REST in embryonic stem cells and multipotent neural stem/progenitor
Autor:
Seock-Ah Im, Hyun Soon Jong, Jung Hyun Park, Jeffrey W. Streb, Ju-Hee Lee, Moon Chang Choi, Yang Ui Lee, Tae-You Kim, Do-Youn Oh, Yung-Jue Bang, Sung Hak Kim
Publikováno v:
The International Journal of Biochemistry & Cell Biology. 40:2534-2543
A-kinase anchoring protein 12 (AKAP12) is known to function as a scaffold protein and as a putative tumor suppressor. However, little is known about the biological role of AKAP12 in hepatic cells. In this study, we performed micro-array analysis to i
Autor:
Nienwen Chow, Jeffrey W. Streb, Jiyuan Chen, Andrew I. Brooks, William E. Van Nostrand, Rashid Deane, Berislav V. Zlokovic, Robert D. Bell, Joseph M. Miano
Publikováno v:
Proceedings of the National Academy of Sciences. 104:823-828
Cerebral angiopathy contributes to cognitive decline and dementia in Alzheimer's disease (AD) through cerebral blood flow (CBF) reductions and dysregulation. We report vascular smooth muscle cells (VSMC) in small pial and intracerebral arteries, whic
Autor:
Christian J. Stoeckert, Yumei Yang, Qiang Sun, Guang Chen, Joseph M. Miano, Xiaochun Long, Jeffrey W. Streb
Publikováno v:
Genome Research. 16:197-207
Serum response factor (SRF) binds a 1216-fold degenerate cis element known as the CArG box. CArG boxes are found primarily in muscle- and growth-factor-associated genes although the full spectrum of functional CArG elements in the genome (the CArGome
Autor:
Joseph M. Miano, Jeffrey W. Streb
Publikováno v:
Journal of Biological Chemistry. 280:28007-28014
A kinase anchoring proteins (AKAPs) assemble and compartmentalize multiprotein signaling complexes at discrete subcellular locales and thus confer specificity to transduction cascades using ubiquitous signaling enzymes, such as protein kinase A. Intr
Publikováno v:
Journal of Biological Chemistry. 279:56014-56023
A Kinase Anchoring Protein 12 (AKAP12; also known as src-suppressed C kinase substrate (SSeCKS) and Gravin) is a multivalent anchoring protein with tumor suppressor activity. Although expression of AKAP12 has been examined in a number of contexts, it
Autor:
Joseph M. Miano, Jeffrey W. Streb
Publikováno v:
Current Drug Target -Cardiovascular & Hematological Disorders. 3:31-57
Retinoids, the natural and synthetic derivatives of vitamin A, exert broad biological effects and have been used clinically to treat a variety of dermatological and neoplastic diseases. The principal mode of action of many retinoids is through the bi
Autor:
Joseph M. Miano, Huang Guo, Berislav V. Zlokovic, Xiaochun Long, Itender Singh, Rashid Deane, Nienwen Chow, William E. Van Nostrand, Jeffrey W. Streb, Abhay P. Sagare, Robert D. Bell, Anna Rubio
Publikováno v:
Nature cell biology. 11(2)
Amyloid beta-peptide (Abeta) deposition in cerebral vessels contributes to cerebral amyloid angiopathy (CAA) in Alzheimer's disease (AD). Here, we report that in AD patients and two mouse models of AD, overexpression of serum response factor (SRF) an