Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Jeffrey W. Pelker"'
Autor:
Rajeev Hotchandani, Neal Jeffrey Green, Junqing Cui, Suzana Marusic, Wei Li, Yonghan Hu, Neelu Kaila, J. Perry Hall, Tam Steve Yik-Kai, Lih-Ling Lin, Jeffrey W. Pelker, Sang Hsu, Huan-Qiu Li, Adrian Huang, Jeffrey Scott Condon, Qin Wang, Jean-Baptiste Telliez, Junjun Wu, Satenig Guler
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 19:3485-3488
Tpl2 (cot/MAP3K8) is an upstream kinase of MEK in the ERK pathway. It plays an important role in Tumor Necrosis Factor-alpha (TNF-alpha) production and signaling. We have discovered that 8-halo-4-(3-chloro-4-fluoro-phenylamino)-6-[(1H-[1,2,3]triazol-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12cb10fa88371076e62dd39cb0719d6c
https://doi.org/10.1016/j.bmcl.2009.05.009
https://doi.org/10.1016/j.bmcl.2009.05.009
Autor:
Marina W.H. Shen, Katherine L. Lee, Suzana Marusic, Nancy Stedman, Xin Xu, Junqing Cui, Lixin Han, Adam J. Borey, Takao Shimizu, Mina Hassan-Zahraee, James D. Clark, Stan F. Wolf, John C. McKew, Fran Donahue, Michael W. Leach, Paresh Thakker, Jeffrey W. Pelker
Publikováno v:
Journal of Neuroimmunology. 204:29-37
Cytosolic phospholipase A2 alpha (cPLA2 alpha) is the rate-limiting enzyme for release of arachidonic acid, which is converted primarily to prostaglandins via the cyclooxygenase (COX) 1/2 pathways, and leukotrienes via the 5-lipoxygenase (LO) pathway
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d61eb8ba9a17021d922a8d5c0091a70a
https://doi.org/10.1016/j.jneuroim.2008.08.012
https://doi.org/10.1016/j.jneuroim.2008.08.012
Autor:
Aiping Jiao, Cara Williams, John P. Leonard, Joy S. Miyashiro, Junqing Cui, Lawrence Mason, Jeffrey W. Pelker, Suzana Marusic, Jason R. Gunn, Paresh Thakker, Charlene DeClercq, Stephen Pazdziorko
Publikováno v:
Journal of Allergy and Clinical Immunology. 115:309-315
Background T H 2-mediated allergic asthma is characterized by eosinophilia, mucus overproduction, and airway hyperresponsiveness (AHR). Although it is clear that T H 2 cells and their cytokines play an important role in AHR, the roles of T H 1 cells
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07b0f0cc1494ff089f89a00c2f933a23
https://doi.org/10.1016/j.jaci.2004.10.046
https://doi.org/10.1016/j.jaci.2004.10.046
Autor:
Deborah Luxenberg, Brenda A. Carito, Beatriz M. Carreno, G. Roger Askew, Tom Brown, Mihai L. Azoitei, Steve Benoit, Michael W. Leach, Christopher Groves, Laura L. Carter, Kim L. Milarski, Jeffrey W. Pelker, Junqing Cui, Mary Collins, Suzana Marusic, Jason Jussif, Gretchen Ireland, Karen Percival
Publikováno v:
Journal of neuroimmunology. 182(1-2)
Interactions between PD-1 and its two differentially expressed ligands, PD-L1 and PD-L2, attenuate T cell activation and effector function. To determine the role of these molecules in autoimmune disease of the CNS, PD-1-/-, PD-L1-/- and PD-L2-/- mice
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2fa608723b65159db30929bd58e9174
https://pubmed.ncbi.nlm.nih.gov/17182110
https://pubmed.ncbi.nlm.nih.gov/17182110
Autor:
Shui-Qing Wei, Joy S. Miyashiro, Paresh Thakker, Mark C. Lavigne, Jeffrey W. Pelker, Aeona M. Wasserman, Michiko Kobayashi, Anthony Wong, Jason R. Gunn, Michael J. Eppihimer
Publikováno v:
Biochemical and biophysical research communications. 324(2)
Matrix metalloproteinases (MMPs) degrade extracellular matrix proteins, which may be responsible for enlargement of alveoli in chronic obstructive pulmonary disease (COPD) and remodeling of pulmonary tissue associated with chronic asthma. Here, we pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d39479024ecbc1c15f4df00caad216f
https://pubmed.ncbi.nlm.nih.gov/15474460
https://pubmed.ncbi.nlm.nih.gov/15474460
Autor:
John P. Leonard, Vincent Ling, Richard F Konz, Kenneth A Jacobs, John Douhan, Jeffrey W. Pelker, Suzana Marusic, Dejun Xuan, Joy S. Miyashiro
Publikováno v:
Neuroscience letters. 332(3)
Experimental autoimmune encephalomyelitis (EAE) is an inflammatory disease of the central nervous system (CNS) that can be induced in susceptible mice by the transfer of autoreactive T cells that recognize myelin basic protein (MBP). The onset and su
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d88c761145a6b1b9ecbb2cb1016b6b31
https://pubmed.ncbi.nlm.nih.gov/12399011
https://pubmed.ncbi.nlm.nih.gov/12399011