Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Jeffrey W. Kleinberger"'
Autor:
Jasmin Divers, Toni I. Pollin, Sherida E. Tollefsen, Dana Dabelea, Lynne L. Levitsky, Lorraine E. Levitt Katz, Jose C. Florez, Fida Bacha, Jennifer N. Todd, Haichen Zhang, Jean M. Lawrence, Jason Flannick, Jeffrey W. Kleinberger, Jeanie B. Tryggestad, Catherine Pihoker, Giuseppina Imperatore, Shylaja Srinivasan
Publikováno v:
Diabetes Care. 44:2312-2319
OBJECTIVE Maturity-onset diabetes of the young (MODY) is frequently misdiagnosed as type 1 or type 2 diabetes. Correct diagnosis may result in a change in clinical treatment and impacts prediction of complications and familial risk. In this study, we
Autor:
Toni I. Pollin, David J. Carey, Philip Levin, Alan R. Shuldiner, Linda J.B. Jeng, Nicholas Ambulos, Danielle Sewell, Kathleen Palmer, Devon Nwaba, Michaela Nicholson, Casey O. Taylor, Coleen M. Damcott, Amy Kimball, Jessica Goehringer, Lee Bromberger, Mallory N. Snyder, Kristina Blessing, Elizabeth A. Streeten, Katharine Bisordi, Trevor J. Mathias, Yue Guan, Kristin A. Maloney, Jeffrey W. Kleinberger, Haichen Zhang
Objective: To implement, disseminate and evaluate a sustainable method for identifying, diagnosing, and promoting individualized therapy for monogenic diabetes. Research Design and Methods: Patients were recruited into the implementation study throug
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ecf26510db576a9dab9b88fc27d27e4a
https://doi.org/10.2337/figshare.19895803.v1
https://doi.org/10.2337/figshare.19895803.v1
Autor:
Haichen Zhang, Jeffrey W. Kleinberger, Kristin A. Maloney, Yue Guan, Trevor J. Mathias, Katharine Bisordi, Elizabeth A. Streeten, Kristina Blessing, Mallory N. Snyder, Lee A. Bromberger, Jessica Goehringer, Amy Kimball, Coleen M. Damcott, Casey O. Taylor, Michaela Nicholson, Devon Nwaba, Kathleen Palmer, Danielle Sewell, Nicholas Ambulos, Linda J.B. Jeng, Alan R. Shuldiner, Philip Levin, David J. Carey, Toni I. Pollin
Publikováno v:
Diabetes care. 45(8)
OBJECTIVE To implement, disseminate, and evaluate a sustainable method for identifying, diagnosing, and promoting individualized therapy for monogenic diabetes. RESEARCH DESIGN AND METHODS Patients were recruited into the implementation study through
Autor:
Toni I. Pollin, Jose C. Florez, Dana Dabelea, Jason Flannick, Jasmin Divers, Catherine Pihoker, Jean M. Lawrence, Giuseppina Imperatore, Fida Bacha, Jeanie B. Tryggestad, Lorraine E. Levitt Katz, Lynne L. Levitsky, Sherida E. Tollefsen, Shylaja Srinivasan, Haichen Zhang, Jeffrey W. Kleinberger, Jennifer N. Todd
Objective: Maturity-onset diabetes of the young (MODY) is frequently misdiagnosed as type 1 or type 2 diabetes. Correct diagnosis may result in a change in clinical treatment and impacts prediction of complications and familial risk. In this study, w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a853cabcae3303bdc1f55a5f4a5b406
https://doi.org/10.2337/figshare.14900994
https://doi.org/10.2337/figshare.14900994
Autor:
Alba Kaci, Bente B. Johansson, Linda Jeng, Monika Ringdal, Pål R. Njølstad, Janne Molnes, Haichen Zhang, Kristin A. Maloney, Jeffrey W. Kleinberger, Aishwarya Pavithram, Toni I. Pollin, Jørn V. Sagen
Publikováno v:
Diabetes. 69
Genetic variants in HNF1B encoding the transcription factor hepatocyte nuclear factor-1 beta (HNF-1B) cause Maturity-Onset Diabetes of the Young type 5 (MODY5; HNF1B-MODY) and are the most common known monogenic cause of developmental kidney disease.
Autor:
Morey W. Haymond, Lynne L. Levitsky, Kenneth C. Copeland, Barbara Linder, Neil H. White, Alan R. Shuldiner, Toni I. Pollin, Jeffrey W. Kleinberger, Rachelle Gandica, Sherida E. Tollefsen
Publikováno v:
Genetics in medicine : official journal of the American College of Medical Genetics
PurposeMonogenic diabetes accounts for 1-2% of diabetes cases. It is often undiagnosed, which may lead to inappropriate treatment. This study was performed to estimate the prevalence of monogenic diabetes in a cohort of overweight/obese adolescents d
Autor:
Jeffrey W. Kleinberger, Toni I. Pollin
Publikováno v:
Annals of the New York Academy of Sciences. 1346:45-56
Diabetes mellitus affects approximately 382 million individuals worldwide and is a leading cause of morbidity and mortality. Over 40 and nearly 80 genetic loci influencing susceptibility to type 1 and type 2 diabetes, respectively, have been identifi
Autor:
Karen K. Takane, Donald K. Scott, Mansoor Tanwir, Jeffrey W. Kleinberger, Ronnie Troxell, Rachel C. Wills, Fatimah G. Salim, Nathalie Fiaschi-Taesch, Andrew F. Stewart, Amy E. Cox, Gabriella P. Casinelli
Publikováno v:
Diabetes
Expansion of pancreatic β-cells is a key goal of diabetes research, yet induction of adult human β-cell replication has proven frustratingly difficult. In part, this reflects a lack of understanding of cell cycle control in the human β-cell. Here,
Autor:
Nathalie Fiaschi-Taesch, Jeffrey W. Kleinberger, Ronnie Troxell, Andrew F. Stewart, Harish Srinivas, Mansoor Tanwir, Donald K. Scott, Gabriella P. Casinelli, Fatimah G. Salim, Karen K. Takane, Amy E. Cox, Rachel C. Wills
Publikováno v:
Diabetes. 62:2460-2470
Harnessing control of human β-cell proliferation has proven frustratingly difficult. Most G1/S control molecules, generally presumed to be nuclear proteins in the human β-cell, are in fact constrained to the cytoplasm. Here, we asked whether G1/S m
The genetic architecture of diabetes mellitus in general and in pregnancy is complex, owing to the multiple types of diabetes that comprise both complex/polygenic forms and monogenic (largely caused by a mutation in a single gene) forms such as matur
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9451eed2e4a811aedf626263309279a2
https://europepmc.org/articles/PMC5507691/
https://europepmc.org/articles/PMC5507691/