Výsledky vyhledávání - "Jeffrey W. Gross"

Next-Generation Compound Delivery Platforms to Support Miniaturized Biology

Autor: Elizabeth Nixon, Lorena A. Kallal, Michael Weglos, Snehal Bhatt, Maggie Truong, Jeffrey W. Gross, Sue Crimmin

Publikováno v: SLAS technology. 24(3)

Recent advancements in science and engineering are revolutionizing our understanding of an individual's disease, and with this knowledge we are gaining an increasingly sophisticated understanding of how discovery can be transformed to deliver persona

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6e435326763cd8daf3e6f65cad3a35c
https://pubmed.ncbi.nlm.nih.gov/30726680

Zobrazit plný text záznamu

Correction: Author Correction: Prioritizing multiple therapeutic targets in parallel using automated DNA-encoded library screening

Autor: Jeffrey A. Messer, Yun Ding, Jianghe Deng, Paolo A. Centrella, Todd L. Graybill, Jean Zhang, Patti McCormick, Carl A. Machutta, Robert H. Bates, John Martin, Joël Lelièvre, Quinn Lu, Jingye Zhou, Alfonso Mendoza-Losana, Xiaopeng Bai, Christopher S. Kollmann, David J. Holmes, Keith Rafferty, Christina S. Pao, Christopher C. Arico-Muendel, Heather O’Keefe, Aaron Coffin, Taylor L. Graham, David Barros-Aguirre, Sandy Chang, Christopher P. Davie, Hongwei Qi, Flora S. Sundersingh, Minghui Wang, Karen A. Ingraham, Jing Chai, Thomas O’Keeffe, Juan Wang, Gang Yao, Lluis Ballell, Jianzhong Huang, Anthony E. Choudhry, Bryan W. King, Andrew J. Pope, Ghotas Evindar, Xiaorong Liu, May Fern Toh, Christine Patricia Donahue, Jeffrey W. Gross, Pan F. Chan, Walter P. Johnson, Ruth Lehr, Hongfeng Deng, Kenneth E Lind, Matt S. Steiginga, Jason W. Dodson, Gurdyal S. Besra, Amy N. Taylor, Devan J. Wilkins, Yue Li, Lawrence M. Szewczuk, Svetlana L. Belyanskaya, Genaro S. Scavello, Sharon Sweitzer, Christopher R. Kwiatkowski, Lynn McCloskey, Bing Xia, Enoch Gao, Christopher B. Phelps, David T. Fosbenner

Publikováno v: Nature Communications, Vol 9, Iss 1, Pp 1-1 (2018)

Nature Communications 8: Article number: 16081 (2017); Published: 17 July 2017, Updated: 13 July 2018 The original version of this Article omitted the following from the Acknowledgements: ‘We thank Robert Kirkpatrick for implementing the high throu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d87eaf46a6638b2650fa3a4f95e4cf2b
https://doi.org/10.1038/ncomms16227

Zobrazit plný text záznamu

Development of a high-content imaging assay for screening compound aggregation

Autor: William G. Bonnette, Jeffrey W. Gross, Geoffrey Quinque, Ann F. Hoffman, Lawrence M. Szewczuk, Yong Jiang, Marc A. Holbert

Publikováno v: Analytical biochemistry. 559

Aggregated compounds can promiscuously and nonspecifically associate with proteins resulting in either false inhibition or activation of many different protein target classes. We developed a high-content imaging assay in a 384-well format using fluor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5747e7249f452482c34062338b410b7
https://pubmed.ncbi.nlm.nih.gov/30142329

Zobrazit plný text záznamu

Integration of Lead Discovery Tactics and the Evolution of the Lead Discovery Toolbox

Autor: Melanie Leveridge, Chun-wa Chung, Darren V. S. Green, Christopher B. Phelps, Jeffrey W. Gross

Publikováno v: SLAS discovery : advancing life sciences RD. 23(9)

There has been much debate around the success rates of various screening strategies to identify starting points for drug discovery. Although high-throughput target-based and phenotypic screening has been the focus of this debate, techniques such as f

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::512ab1c39012711aca082529a4e23dae
https://pubmed.ncbi.nlm.nih.gov/29874524

Zobrazit plný text záznamu

Discovery of 1-(1,3,5-triazin-2-yl)piperidine-4-carboxamides as inhibitors of soluble epoxide hydrolase

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 23:3584-3588

1-(1,3,5-Triazin-yl)piperidine-4-carboxamide inhibitors of soluble epoxide hydrolase were identified from high through-put screening using encoded library technology. The triazine heterocycle proved to be a critical functional group, essential for hi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f13355828ceff27b46501569a75e0dba
https://doi.org/10.1016/j.bmcl.2013.04.019

Zobrazit plný text záznamu

Prioritizing multiple therapeutic targets in parallel using automated DNA-encoded library screening

Autor: Todd L. Graybill, John D. Martin, Jason W. Dodson, Hongfeng Deng, Christopher P. Davie, Christopher C. Arico-Muendel, Minghui Wang, Hongwei Qi, Sandy S. Chang, David J. Holmes, Karen A. Ingraham, Kenneth E Lind, Heather O’Keefe, Carl A. Machutta, David Barros-Aguirre, Christine Patricia Donahue, Christina S. Pao, Jeffrey W. Gross, Ghotas Evindar, Jean Zhang, Bing Xia, Juan Wang, Patti McCormick, Xiaorong Liu, Jianzhong Huang, Joël Lelièvre, Quinn Lu, Pan F. Chan, Matt S. Steiginga, Lynn McCloskey, Christopher S. Kollmann, Taylor L. Graham, Xiaopeng Bai, Jing Chai, Yue Li, Walter P. Johnson, Ruth Lehr, Lawrence M. Szewczuk, Jingye Zhou, Lluis Ballell, Genaro S. Scavello, Robert H. Bates, Anthony E. Choudhry, Aaron Coffin, Sharon Sweitzer, Christopher R. Kwiatkowski, Andrew J. Pope, Enoch Gao, Christopher B. Phelps, David T. Fosbenner, Keith Rafferty, Thomas O’Keeffe, Gang Yao, Bryan W. King, Svetlana L. Belyanskaya, May Fern Toh, Gurdyal S. Besra, Amy N. Taylor, Devan J. Wilkins, Alfonso Mendoza-Losana, Paolo A. Centrella, Flora S. Sundersingh, Jeffrey A. Messer, Yun Ding, Jianghe Deng

Publikováno v: Nature Communications
Nature Communications, Vol 8, Iss 1, Pp 1-11 (2017)

The identification and prioritization of chemically tractable therapeutic targets is a significant challenge in the discovery of new medicines. We have developed a novel method that rapidly screens multiple proteins in parallel using DNA-encoded libr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6fd5399c3ed244a244dc84c19085f169
https://pubmed.ncbi.nlm.nih.gov/30004092

Zobrazit plný text záznamu

Thiol-based angiotensin-converting enzyme 2 inhibitors: P1 modifications for the exploration of the S1 subsite

Autor: David N. Deaton, Enoch N. Gao, Kevin P. Graham, Jeffrey W. Gross, Aaron B. Miller, John M. Strelow

Publikováno v: Bioorganic & Medicinal Chemistry Letters

Graphical abstract Screening of a metalloprotease library led to the identification of a thiol-based dual ACE/NEP inhibitor as a potent ACE2 inhibitor. Modifications of the P1 benzyl moiety led to improvements in ACE2 potency as well as to increased

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::873406abf04c334299a763392af8a8f6
http://europepmc.org/articles/PMC7126659

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání