Zobrazeno 1 - 10
of 213
pro vyhledávání: '"Jeffrey W Taub"'
Autor:
Holly Edwards, Mara Rubenstein, Alan A Dombkowski, J Timothy Caldwell, Roland Chu, Ana C Xavier, Ryan Thummel, Melody Neely, Larry H Matherly, Yubin Ge, Jeffrey W Taub
Publikováno v:
PLoS ONE, Vol 11, Iss 8, p e0161539 (2016)
In this study we sought to identify genetic factors associated with the presenting white blood cell (WBC) count in B-precursor acute lymphoblastic leukemia (BP-ALL). Using ETV6-RUNX1-positive BP-ALL patient samples, a homogeneous subtype, we identifi
Externí odkaz:
https://doaj.org/article/bf68ff7fa70f4596baf19a578a6a8903
Autor:
Chengzhi Xie, Christina Drenberg, Holly Edwards, J Timothy Caldwell, Wei Chen, Hiroto Inaba, Xuelian Xu, Steven A Buck, Jeffrey W Taub, Sharyn D Baker, Yubin Ge
Publikováno v:
PLoS ONE, Vol 8, Iss 11, p e79106 (2013)
Acute myeloid leukemia (AML) remains a challenging disease to treat and urgently requires new therapies to improve its treatment outcome. In this study, we investigated the molecular mechanisms underlying the cooperative antileukemic activities of pa
Externí odkaz:
https://doaj.org/article/87a3ed3a1db245feaeb470f0d47acbc5
Autor:
John Timothy Caldwell, Holly Edwards, Alan A Dombkowski, Steven A Buck, Larry H Matherly, Yubin Ge, Jeffrey W Taub
Publikováno v:
PLoS ONE, Vol 8, Iss 7, p e68601 (2013)
It has been previously shown that acute myeloid leukemia (AML) patients with higher levels of GATA1 expression have poorer outcomes. Furthermore, pediatric Down syndrome (DS) patients with acute megakaryocytic leukemia (AMKL), whose blast cells almos
Externí odkaz:
https://doaj.org/article/b1d74a4ff5b541909f5627ced25f1d62
Autor:
Guan Wang, Holly Edwards, J Timothy Caldwell, Steven A Buck, William Y Qing, Jeffrey W Taub, Yubin Ge, Zhihong Wang
Publikováno v:
PLoS ONE, Vol 8, Iss 9, p e76662 (2013)
High-risk neuroblastoma remains a therapeutic challenge with a long-term survival rate of less than 40%. Therefore, new agents are urgently needed to overcome chemotherapy resistance so as to improve the treatment outcome of this deadly disease. Hist
Externí odkaz:
https://doaj.org/article/a011d84d096a4cd4afdf4cac5b388ab8
Autor:
Guan Wang, Jing He, Jianyun Zhao, Wenting Yun, Chengzhi Xie, Jeffrey W Taub, Asfar Azmi, Ramzi M Mohammad, Yan Dong, Wei Kong, Yingjie Guo, Yubin Ge
Publikováno v:
PLoS ONE, Vol 7, Iss 12, p e52095 (2012)
BACKGROUND:Pancreatic cancer is a highly malignant disease with an extremely poor prognosis. Histone deacetylase inhibitors (HDACIs) have shown promising antitumor activities against preclinical models of pancreatic cancer, either alone or in combina
Externí odkaz:
https://doaj.org/article/e0ad368028d0423ba1b0b936c838c226
Autor:
Ana C Xavier, Holly Edwards, Alan A Dombkowski, Tugce B Balci, Jason N Berman, Graham Dellaire, Chengzhi Xie, Steven A Buck, Larry H Matherly, Yubin Ge, Jeffrey W Taub
Publikováno v:
PLoS ONE, Vol 6, Iss 11, p e27486 (2011)
Acute megakaryocytic leukemia (AMkL) in Down syndrome (DS) children is uniformly associated with somatic GATA1 mutations, which result in the synthesis of a shorter protein (GATA1s) with altered transactivation activity compared to the wild-type GATA
Externí odkaz:
https://doaj.org/article/cb472333e4c342d39a28ad9e72a23a6f
Publikováno v:
eJHaem, Vol 4, Iss 2, Pp 488-490 (2023)
Externí odkaz:
https://doaj.org/article/0ccf9c3b3b934de38ba3296b9ca6d759
Autor:
Shuangshuang Wu, Holly Edwards, Deying Wang, Shuang Liu, Xinan Qiao, Jenna Carter, Yue Wang, Jeffrey W. Taub, Guan Wang, Yubin Ge
Publikováno v:
Cells, Vol 11, Iss 17, p 2752 (2022)
FMS-like tyrosine kinase 3 (FLT3)-internal tandem duplication (FLT3-ITD) mutations occur in about 25% of all acute myeloid leukemia (AML) patients and confer a poor prognosis. FLT3 inhibitors have been developed to treat patients with FLT3-mutated AM
Externí odkaz:
https://doaj.org/article/367c54ab8c64482a8189519778232544
Autor:
Xinyu Li, Yongwei Su, Katie Hege, Gerard Madlambayan, Holly Edwards, Tristan Knight, Lisa Polin, Juiwanna Kushner, Sijana H. Dzinic, Kathryn White, Jay Yang, Regan Miller, Guan Wang, Lijing Zhao, Yue Wang, Hai Lin, Jeffrey W. Taub, Yubin Ge
Publikováno v:
Haematologica, Vol 106, Iss 5 (2020)
Venetoclax is a promising agent in the treatment of acute myeloid leukemia, though its antileukemic activity is limited to combination therapies. Mcl-1 downregulation, Bim upregulation, and DNA damage have been identified as potential ways to enhance
Externí odkaz:
https://doaj.org/article/3e3e34e78f4b4b259f1f44a78a6c22ea
Autor:
Xinyu Li, Yongwei Su, Gerard Madlambayan, Holly Edwards, Lisa Polin, Juiwanna Kushner, Sijana H. Dzinic, Kathryn White, Jun Ma, Tristan Knight, Guan Wang, Yue Wang, Jay Yang, Jeffrey W. Taub, Hai Lin, Yubin Ge
Publikováno v:
Haematologica, Vol 104, Iss 11 (2019)
Induction therapy for patients with acute myeloid leukemia (AML) has remained largely unchanged for over 40 years, while overall survival rates remain unacceptably low, highlighting the need for new therapies. The PI3K/Akt pathway is constitutively a
Externí odkaz:
https://doaj.org/article/f997a12ee3164750a553d1a5d8fd8e8e