Výsledky vyhledávání - "Jeffrey W Fisher"

Akademický článek

Quantitative global sensitivity analysis of a biologically based dose-response pregnancy model for the thyroid endocrine system

Autor: Annie eLumen, Kevin eMcNally, Nysia eGeorge, Jeffrey W Fisher, George D Loizou

Publikováno v: Frontiers in Pharmacology, Vol 6 (2015)

A deterministic biologically based dose-response model for the thyroidal system in a near-term pregnant woman and the fetus was recently developed to evaluate quantitatively thyroid hormone perturbations. The current work focuses on conducting a quan

Externí odkaz: https://doaj.org/article/cf2901a5668f4f0193c2aafaeb76a43b

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Akademický článek

Unravelling bisphenol A pharmacokinetics using physiologically based pharmacokinetic modeling

Autor: Xiaoxia eYang, Jeffrey W Fisher

Publikováno v: Frontiers in Pharmacology, Vol 5 (2015)

Physiologically based pharmacokinetic (PBPK) models integrate both chemical- and system-specific information into a mathematical framework, offering a mechanistic approach to predict the internal dose metrics of a chemical and an ability to perform s

Externí odkaz: https://doaj.org/article/b87d0ab7bc7d48ce97be72a6e1e32a70

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Akademický článek

Development of a physiologically based model to describe the pharmacokinetics of methylphenidate in juvenile and adult humans and nonhuman primates.

Autor: Xiaoxia Yang, Suzanne M Morris, Jeffery M Gearhart, Christopher D Ruark, Merle G Paule, William Slikker, Donald R Mattison, Benedetto Vitiello, Nathan C Twaddle, Daniel R Doerge, John F Young, Jeffrey W Fisher

Publikováno v: PLoS ONE, Vol 9, Iss 9, p e106101 (2014)

The widespread usage of methylphenidate (MPH) in the pediatric population has received considerable attention due to its potential effect on child development. For the first time a physiologically based pharmacokinetic (PBPK) model has been developed

Externí odkaz: https://doaj.org/article/b5b645e24fba41e9a37210a41f624b02

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Akademický článek

24-hour human urine and serum profiles of bisphenol A following ingestion in soup: Individual pharmacokinetic data and emographics

Autor: Justin G. Teeguarden, Nathan C. Twaddle, Mona I. Churchwell, Xiaoxia Yang, Jeffrey W. Fisher, Liesel M. Seryak, Daniel R. Doerge

Publikováno v: Data in Brief, Vol 4, Iss C, Pp 83-86 (2015)

Here we present data to evaluate potential absorption of Bisphenol A through non-metabolizing tissues of the upper digestive tract. Concurrent serum and urine concentrations of d6-BPA, and its glucuronide and sulfate conjugates, were measured over a

Externí odkaz: https://doaj.org/article/ead971fdcfe641ac9ee1573b194405d8

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Ontogeny equations with probability distributions for anthropomorphic measurements in preterm and term neonates and infants for use in a PBPK model

Autor: John A. Troutman, Darshan Mehta, Jeffrey W. Fisher, Huali Wu, Xiaoxia Yang, Mary C. Sullivan, Jian Wang, Gilbert J. Burckart

Publikováno v: Computational Toxicology. 11:101-117

Fitted algebraic equations with probability distributions are presented to predict the maturation of selected physiological parameters that occur postnatally in preterm and term neonates through early infancy. The neonatal population, in particular p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8377ce9ba67094f74990abc3fbd352e4
https://doi.org/10.1016/j.comtox.2019.03.007

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Metabolism and disposition of arsenic species from oral dosing with sodium arsenite in neonatal CD-1 mice. IV. Toxicokinetics following gavage administration and lactational transfer

Autor: Daniel R. Doerge, Frederick A. Beland, Nathan C. Twaddle, Jeffrey W. Fisher, Michelle Vanlandingham

Publikováno v: Food and Chemical Toxicology. 123:28-41

Arsenic is a ubiquitous contaminant, with typical human dietary intake below 1 μg/kg bw/d and extreme drinking water exposures up to ∼50 μg/kg bw/d. The formation and binding of trivalent metabolites are central to arsenic toxicity and strong hum

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::982caa54c85cafc7180a58abc9ed1ac9
https://doi.org/10.1016/j.fct.2018.10.046

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Using mathematical modeling to infer the valence state of arsenicals in tissues: A PBPK model for dimethylarsinic acid (DMAV) and dimethylarsinous acid (DMAIII) in mice

Autor: Lydia M. Bilinsky, Jeffrey W. Fisher, David J. Thomas

Publikováno v: Journal of Theoretical Biology. 461:215-229

Chronic exposure to inorganic arsenic (iAs), a contaminant of water and food supplies, is associated with many adverse health effects. A notable feature of iAs metabolism is sequential methylation reactions which produce mono- and di-methylated arsen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c10cb39f39631d3dd40d02649d52a6fa
https://doi.org/10.1016/j.jtbi.2018.10.051

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Creatinine-Based Renal Function Assessment in Pediatric Drug Development: An Analysis Using Clinical Data for Renally Eliminated Drugs

Autor: Yifei Zhang, Jeffrey W. Fisher, Catherine M.T. Sherwin, Daniel Gonzalez, Yaning Wang, Charles J. Ganley, Jian Wang, Lynne Yao, Qunshu Zhang, Mona Khurana, Gilbert J. Burckart

Publikováno v: Clin Pharmacol Ther

The estimated glomerular filtration rate (eGFR) equations based on serum creatinine (SCR) have been used for pediatric dose adjustment in drug labeling. This study evaluated the performance of those equations in estimating individual clearance of dru

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9313fc80d83dda4c2906a69af2c50bc5
https://pubmed.ncbi.nlm.nih.gov/32696977

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