Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Jeffrey W, Santoso"'
Autor:
Mher Garibyan, Tyler Hoffman, Thijs Makaske, Stephanie K. Do, Yifan Wu, Brian A. Williams, Alexander R. March, Nathan Cho, Nicolas Pedroncelli, Ricardo Espinosa Lima, Jennifer Soto, Brooke Jackson, Jeffrey W. Santoso, Ali Khademhosseini, Matt Thomson, Song Li, Megan L. McCain, Leonardo Morsut
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-21 (2024)
Abstract Synthetic Notch (synNotch) receptors are genetically encoded, modular synthetic receptors that enable mammalian cells to detect environmental signals and respond by activating user-prescribed transcriptional programs. Although some materials
Externí odkaz:
https://doaj.org/article/7b52332128de4f3eaab5e1d7a7349b0e
Autor:
Mher Garibyan, Tyler Hoffman, Thijs Makaske, Stephanie K. Do, Yifan Wu, Brian A. Williams, Alexander R. March, Nathan Cho, Nicolas Pedroncelli, Ricardo Espinosa Lima, Jennifer Soto, Brooke Jackson, Jeffrey W. Santoso, Ali Khademhosseini, Matt Thomson, Song Li, Megan L. McCain, Leonardo Morsut
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-1 (2024)
Externí odkaz:
https://doaj.org/article/c53f5253835a499695a52fb2a466a8ee
Autor:
Florian Barthélémy, Jeffrey W. Santoso, Laura Rabichow, Rongcheng Jin, Isaiah Little, Stanley F. Nelson, Megan L. McCain, M. Carrie Miceli
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 10 (2022)
In vitro models of patient-derived muscle allow for more efficient development of genetic medicines for the muscular dystrophies, which often present mutation-specific pathologies. One popular strategy to generate patient-specific myotubes involves r
Externí odkaz:
https://doaj.org/article/73fc79b089c845ef877ae95d996f78e5
Autor:
Jeffrey W. Santoso, Xiling Li, Divya Gupta, Gio C. Suh, Eric Hendricks, Shaoyu Lin, Sarah Perry, Justin K. Ichida, Dion Dickman, Megan L. McCain
Publikováno v:
APL Bioengineering, Vol 5, Iss 3, Pp 036101-036101-16 (2021)
To develop effective cures for neuromuscular diseases, human-relevant in vitro models of neuromuscular tissues are critically needed to probe disease mechanisms on a cellular and molecular level. However, previous attempts to co-culture motor neurons
Externí odkaz:
https://doaj.org/article/6fd450d7c35443ed846926f94cea84d9
Autor:
Jeffrey W. Santoso, Megan L. McCain
Publikováno v:
Disease Models & Mechanisms, Vol 13, Iss 7 (2020)
Organs-on-chips are broadly defined as microfabricated surfaces or devices designed to engineer cells into microscale tissues with native-like features and then extract physiologically relevant readouts at scale. Because they are generally compatible
Externí odkaz:
https://doaj.org/article/06ef44b2229d415188a7be9f5322d53c
Publikováno v:
Bioengineering, Vol 8, Iss 1, p 6 (2021)
Engineered in vitro models of skeletal muscle are essential for efficiently screening drug safety and efficacy. However, conventional culture substrates poorly replicate physical features of native muscle and do not support long-term culture, which l
Externí odkaz:
https://doaj.org/article/b10a80a2d61f4cb2a8f7d8b9afa9566b
Autor:
Jeffrey W. Santoso, Paul R August, Divya Gupta, Megan L. McCain, Nethika R. Ariyasinghe, Mark J. Pincus
Publikováno v:
Annals of Biomedical Engineering. 49:523-535
Many techniques for engineering and interrogating three-dimensional (3-D) muscle bundles from animal- or patient-derived myoblasts have recently been developed to overcome the limitations of existing in vitro and in vivo model systems. However, many
Autor:
Nathan Cho, Nethika R. Ariyasinghe, Divya Gupta, Megan L. McCain, Davi M. Lyra-Leite, Jeffrey W. Santoso, Andrew P. Petersen
Publikováno v:
Integrative Biology. 12:34-46
Disruptions to cardiac tissue microstructure are common in diseased or injured myocardium and are known substrates for arrhythmias. However, we have a relatively coarse understanding of the relationships between myocardial tissue microstructure, prop
Publikováno v:
Bioengineering
Volume 8
Issue 1
Bioengineering, Vol 8, Iss 6, p 6 (2021)
Volume 8
Issue 1
Bioengineering, Vol 8, Iss 6, p 6 (2021)
Engineered in vitro models of skeletal muscle are essential for efficiently screening drug safety and efficacy. However, conventional culture substrates poorly replicate physical features of native muscle and do not support long-term culture, which l
Autor:
Megan L. McCain, Jeffrey W. Santoso
Publikováno v:
Disease Models & Mechanisms
article-version (VoR) Version of Record
Disease Models & Mechanisms, Vol 13, Iss 7 (2020)
article-version (VoR) Version of Record
Disease Models & Mechanisms, Vol 13, Iss 7 (2020)
Organs-on-chips are broadly defined as microfabricated surfaces or devices designed to engineer cells into microscale tissues with native-like features and then extract physiologically relevant readouts at scale. Because they are generally compatible