Zobrazeno 1 - 10
of 43
pro vyhledávání: '"Jeffrey W, Johannes"'
Autor:
Adriana E. Tron, Matthew A. Belmonte, Ammar Adam, Brian M. Aquila, Lawrence H. Boise, Elisabetta Chiarparin, Justin Cidado, Kevin J. Embrey, Eric Gangl, Francis D. Gibbons, Gareth P. Gregory, David Hargreaves, J. Adam Hendricks, Jeffrey W. Johannes, Ricky W. Johnstone, Steven L. Kazmirski, Jason G. Kettle, Michelle L. Lamb, Shannon M. Matulis, Ajay K. Nooka, Martin J. Packer, Bo Peng, Philip B. Rawlins, Daniel W. Robbins, Alwin G. Schuller, Nancy Su, Wenzhan Yang, Qing Ye, Xiaolan Zheng, J. Paul Secrist, Edwin A. Clark, David M. Wilson, Stephen E. Fawell, Alexander W. Hird
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
High expression of Mcl-1 promotes tumorigenesis and resistance to anticancer therapies. Here they report a macrocyclic molecule with high selectivity and affinity for Mcl-1 that exhibits potent anti-tumor effects as single agent and in combination wi
Externí odkaz:
https://doaj.org/article/814ff3ef6b204d84917e2b025f3e1da9
Autor:
Cameron H. Chrisman, Max Kudisch, Katherine O. Puffer, Trevor K. Stewart, Yisrael M. L. Lamb, Chern-Hooi Lim, Randolph Escobar, Pall Thordarson, Jeffrey W. Johannes, Garret M. Miyake
Publikováno v:
Journal of the American Chemical Society.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::42d21e94dc9d9352b3a05bf52806e128
https://doi.org/10.1021/jacs.3c02784
https://doi.org/10.1021/jacs.3c02784
Autor:
David Hargreaves, Rodrigo J. Carbajo, Michael S. Bodnarchuk, Kevin Embrey, Philip B. Rawlins, Martin Packer, Sébastien L. Degorce, Alexander W. Hird, Jeffrey W. Johannes, Elisabetta Chiarparin, Markus Schade
Publikováno v:
Proceedings of the National Academy of Sciences. 120
The structure-based design of small-molecule inhibitors targeting protein–protein interactions (PPIs) remains a huge challenge as the drug must bind typically wide and shallow protein sites. A PPI target of high interest for hematological cancer th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d2bffac636430c22137888d848f374ca
https://doi.org/10.1073/pnas.2221967120
https://doi.org/10.1073/pnas.2221967120
Autor:
Huawei Chen, Corinne Reimer, Stephen E. Fawell, Keith Mikule, Michael Zinda, Edward W. Tate, Paul D. Lyne, Jonathan R. Dry, Deborah Lawson, Michelle L. Lamb, Jeffrey W. Johannes, David A. Scott, Dan Widzowski, Michele Mayo, Ryan T. Howard, Nancy Su, Jiaquan Wu, Farzin Gharahdaghi, Wenxian Wang, Xin Wang, Jingwen Zhang, Philip Petteruti, Tony Cheung, Shaun E. Grosskurth, Zebin Wang
PARP proteins represent a class of post-translational modification enzymes with diverse cellular functions. Targeting PARPs has proven to be efficacious clinically, but exploration of the therapeutic potential of PARP inhibition has been limited to t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e72f443eea55562ffa6cc913b43229d
https://doi.org/10.1158/0008-5472.c.6510161.v1
https://doi.org/10.1158/0008-5472.c.6510161.v1
Autor:
Huawei Chen, Corinne Reimer, Stephen E. Fawell, Keith Mikule, Michael Zinda, Edward W. Tate, Paul D. Lyne, Jonathan R. Dry, Deborah Lawson, Michelle L. Lamb, Jeffrey W. Johannes, David A. Scott, Dan Widzowski, Michele Mayo, Ryan T. Howard, Nancy Su, Jiaquan Wu, Farzin Gharahdaghi, Wenxian Wang, Xin Wang, Jingwen Zhang, Philip Petteruti, Tony Cheung, Shaun E. Grosskurth, Zebin Wang
Supplemental materials
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25c90f8ab65849ea462ef14da7c54638
https://doi.org/10.1158/0008-5472.22418558.v1
https://doi.org/10.1158/0008-5472.22418558.v1
Autor:
Jeffrey W. Johannes, Fiona Pachl, Amber Balazs, Tieguang Yao, C. Larner, Lisa McWilliams, Marianne Schimpl, Scott W. Martin, Kevin J. Embrey, Tom D. Heightman, Paul Hemsley, Jonathan P. Orme, Derek Barratt, Giuditta Illuzzi, Andrew Madin, Paolo Di Fruscia, Avipsa Ghosh, Martin J. Packer, Scott D. Edmondson, Elisabetta Leo, Xiaolan Zheng, Matthew D. Chuba, Xiaohui Pei, Mark J. O'Connor, Verity Talbot, Ke Zhang, Stephen Fawell, Elizabeth Underwood, Anna Staniszewska, Lina Liu, Lin Xue, Sonja J. Gill, Anders Gunnarsson, Andrew Pike, Susan E. Critchlow, Jeffrey G. Varnes, Andrew X. Zhang, Sébastien L. Degorce, J. Lane, Sudhir M. Hande, Hongyao She, Sabina Cosulich, Michal Bista
Publikováno v:
Journal of Medicinal Chemistry. 64:14498-14512
Poly-ADP-ribose-polymerase (PARP) inhibitors have achieved regulatory approval in oncology for homologous recombination repair deficient tumors including BRCA mutation. However, some have failed in combination with first-line chemotherapies, usually
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6d5da59f02fe0bf1798c2492422c31c3
https://doi.org/10.1021/acs.jmedchem.1c01012
https://doi.org/10.1021/acs.jmedchem.1c01012
Autor:
Emily C. Erickson, Inchul You, Grace Perry, Aurelien Dugourd, Katherine A. Donovan, Claire Crafter, Jeffrey W. Johannes, Stuart Williamson, Jennifer I. Moss, Susana Ros, Robert E. Ziegler, Simon T. Barry, Eric S. Fischer, Nathanael S. Gray, Ralitsa R. Madsen, Alex Toker
Over 50% of human tumors display hyperactivation of the serine/threonine kinase AKT. Despite evidence of clinical efficacy, there remains scope to improve upon the therapeutic window of the current generation of AKT inhibitors. Here we report the dev
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c9936b8bb18af7326b2f253aaaab2a45
https://doi.org/10.1101/2022.10.11.511726
https://doi.org/10.1101/2022.10.11.511726
Publikováno v:
The Journal of organic chemistry. 87(14)
While trifluoromethylthiolation of aryl halides has been extensively explored, the current methods require complex and/or air-sensitive catalysts. Reported here is a method employing a bench-stable Ni(II) salt and an iridium photocatalyst that can me
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a885cbdc37d670deeddd4e40a9fc018
https://pubmed.ncbi.nlm.nih.gov/35786936
https://pubmed.ncbi.nlm.nih.gov/35786936
Autor:
Renee L. DesJarlais, Sebastian Salentin, Klavs F. Jensen, Tommi S. Jaakkola, Daniel J. Griffin, Daniel Rodriguez Greve, Li Xing, Richard I. Robinson, Justin S. Cisar, Xinjun Hou, Constantine Kreatsoulas, Jeffrey W. Johannes, Andrew Palmer, Christos A. Nicolaou, Juan C. Alvarez, Regina Barzilay, William H. Green, Thomas J. Struble, Connor W. Coley, Ola Engkvist, Brian R. Lahue, Milan Chytil, Scott P. Brown, Scott Alan Frank, Daniel J. Price, Georg Mogk, Miriam Mathea
Publikováno v:
Journal of Medicinal Chemistry
Artificial intelligence and machine learning have demonstrated their potential role in predictive chemistry and synthetic planning of small molecules; there are at least a few reports of companies employing in silico synthetic planning into their ove
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c43527bb6f8e5a5f497ea36b932a4df7
https://doi.org/10.1021/acs.jmedchem.9b02120
https://doi.org/10.1021/acs.jmedchem.9b02120
Publikováno v:
Chemistry – A European Journal. 26:5168-5173
While carbon-heteroatom cross-coupling reactions have been extensively studied, many methods are specific and limited to a particular set of substrates or functional groups. Reported here is a general method that allows for C-O, C-N and C-S cross-cou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0c55b95d55b0af8c56edf6a35f4d2e7
https://doi.org/10.1002/chem.202000052
https://doi.org/10.1002/chem.202000052