Zobrazeno 1 - 10
of 239
pro vyhledávání: '"Jeffrey W, Dalley"'
Autor:
Elena Martín-González, Ángeles Prados-Pardo, Stephen J. Sawiak, Jeffrey W. Dalley, Daniel Padro, Pedro Ramos-Cabrer, Santiago Mora, Margarita Moreno-Montoya
Publikováno v:
Behavioral and Brain Functions, Vol 19, Iss 1, Pp 1-15 (2023)
Abstract Compulsivity is considered a transdiagnostic dimension in obsessive–compulsive and related disorders, characterized by heterogeneous cognitive and behavioral phenotypes associated with abnormalities in cortico-striatal-thalamic-cortical ci
Externí odkaz:
https://doaj.org/article/e5f202b4047b401da33ed3dec68e0291
Autor:
Riccardo Dore, Laura Watson, Stefanie Hollidge, Christin Krause, Sarah Christine Sentis, Rebecca Oelkrug, Cathleen Geißler, Kornelia Johann, Mehdi Pedaran, Greta Lyons, Nuria Lopez-Alcantara, Julia Resch, Friedhelm Sayk, Karl Alexander Iwen, Andre Franke, Teide Jens Boysen, Jeffrey W. Dalley, Kristina Lorenz, Carla Moran, Kirsten L. Rennie, Anders Arner, Henriette Kirchner, Krishna Chatterjee, Jens Mittag
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-11 (2023)
Abstract Mutations in thyroid hormone receptor α1 (TRα1) cause Resistance to Thyroid Hormone α (RTHα), a disorder characterized by hypothyroidism in TRα1-expressing tissues including the heart. Surprisingly, we report that treatment of RTHα pat
Externí odkaz:
https://doaj.org/article/39463f62342d495e8fd52912473497e2
Autor:
Katharina Zühlsdorff, Juan Verdejo-Román, Luke Clark, Natalia Albein-Urios, Carles Soriano-Mas, Rudolf N. Cardinal, Trevor W. Robbins, Jeffrey W. Dalley, Antonio Verdejo-García, Jonathan W. Kanen
Publikováno v:
BJPsych Open, Vol 10 (2024)
Background Individuals with cocaine use disorder or gambling disorder demonstrate impairments in cognitive flexibility: the ability to adapt to changes in the environment. Flexibility is commonly assessed in a laboratory setting using probabilistic r
Externí odkaz:
https://doaj.org/article/f7034e70efe3417a95e07f4d68a79c04
Autor:
Ethan G. Dutcher, Laura Lopez-Cruz, E. A. Claudia Pama, Mary-Ellen Lynall, Iris C. R. Bevers, Jolyon A. Jones, Shahid Khan, Stephen J. Sawiak, Amy L. Milton, Menna R. Clatworthy, Trevor W. Robbins, Edward T. Bullmore, Jeffrey W. Dalley
Publikováno v:
Translational Psychiatry, Vol 13, Iss 1, Pp 1-11 (2023)
Abstract Early-life stress (ELS) or adversity, particularly in the form of childhood neglect and abuse, is associated with poor mental and physical health outcomes in adulthood. However, whether these relationships are mediated by the consequences of
Externí odkaz:
https://doaj.org/article/fd561f9d616d4904bddd36a9d6dd5cec
Autor:
Chun-Hao Chang, Wen-Ya Peng, Wan-Hsin Lee, Tung-Yi Lin, Muh-Hwa Yang, Jeffrey W. Dalley, Tung-Hu Tsai
Publikováno v:
EBioMedicine, Vol 95, Iss , Pp 104748- (2023)
Summary: Background: Molnupiravir is an orally bioavailable prodrug of the nucleoside analogue β-D-N4-hydroxycytidine (NHC) and is used to treat coronavirus disease 2019 (COVID-19). However, the pharmacokinetics and transplacental transfer of molnup
Externí odkaz:
https://doaj.org/article/ea27156d271348a2a78f0ff4a9a7ce97
Autor:
Katharina Zühlsdorff, Laura López-Cruz, Ethan G. Dutcher, Jolyon A. Jones, Claudia Pama, Stephen Sawiak, Shahid Khan, Amy L. Milton, Trevor W. Robbins, Edward T. Bullmore, Jeffrey W. Dalley
Publikováno v:
Neurobiology of Stress, Vol 22, Iss , Pp 100507- (2023)
Major depressive disorder (MDD) is a stress-related condition hypothesized to involve aberrant reinforcement learning (RL) with positive and negative stimuli. The present study investigated whether repeated early maternal separation (REMS) stress, a
Externí odkaz:
https://doaj.org/article/5a22d5be03f24cbcabfa849082431ca6
Publikováno v:
EBioMedicine, Vol 81, Iss , Pp 104095- (2022)
Summary: Background: Remdesivir was the first prodrug approved to treat coronavirus disease 2019 (COVID-19) and has the potential to be used during pregnancy. However, it is not known whether remdesivir and its main metabolite, GS-441524 have the pot
Externí odkaz:
https://doaj.org/article/ac67bae12fc34227aafe4f6595334ef8
Autor:
Johannes Levin, Nand Sing, Sue Melbourne, Amber Morgan, Carla Mariner, Maria Grazia Spillantini, Michal Wegrzynowicz, Jeffrey W. Dalley, Simon Langer, Sergey Ryazanov, Andrei Leonov, Christian Griesinger, Felix Schmidt, Daniel Weckbecker, Kai Prager, Torsten Matthias, Armin Giese
Publikováno v:
EBioMedicine, Vol 80, Iss , Pp 104021- (2022)
Summary: Background: Synucleinopathies such as Parkinson ́s disease (PD), Dementia with Lewy bodies (DLB) and Multiple System Atrophy (MSA) are characterized by deposition of misfolded and aggregated α-synuclein. Small aggregates (oligomers) of α-
Externí odkaz:
https://doaj.org/article/2aeca4c5452945a2b232932da803dc99
Autor:
Yung-Yi Cheng, Teresa Zheng, Michael W. Chang, Jeffrey W. Dalley, Yu-Jen Chen, Tung-Hu Tsai, Chen-Hsi Hsieh
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
BackgroundThe optimal procedure for combining radiotherapy (RT) with tamoxifen treatment is controversial as RT may alter the pharmacokinetics and biotransformation of tamoxifen. The present study investigated this potential interaction by assessing
Externí odkaz:
https://doaj.org/article/332c0717e2eb40808d6cb76f38cad3a1
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 145, Iss , Pp 112466- (2022)
Tamoxifen, a widely prescribed medication in premenopausal women diagnosed with hormone-dependent breast cancer, is potentially co-prescribed with Hedyotis diffusa (H. diffusa), particularly in Taiwan. However, no related report has investigated the
Externí odkaz:
https://doaj.org/article/6e520603c9484046a50077cffff07e98