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Autor:
Joy Wang, Deepali Phadke, James E. Dowling, Thomas Engber, Eman Ayyub, Xiaowei Jin, Petter Russell C, Kurt Van Vloten, Jeffrey Vessels, Chang He Xi, Serajul Haque, Gnanasambandam Kumaravel
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 15:4809-4813
Potent and selective antagonists of the adenosine A2A receptor often contain a nitrogen-rich fused-ring heterocyclic core. Replacement of the core with an isomeric ring system has previously been shown to improve target affinity, selectivity, and in