Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Jeffrey Velasquez"'
Autor:
Rebecca Page, Kin Moy, Eric C. Sims, Jeffrey Velasquez, Brendan McManus, Carina Grittini, Thomas L. Clayton, Raymond C. Stevens
Publikováno v:
BioTechniques, Vol 37, Iss 3, Pp 364-370 (2004)
Externí odkaz:
https://doaj.org/article/bcec3072010145a78f1a83ad1f273f60
Publikováno v:
Nature Protocols. 15:144-160
G protein-coupled receptors (GPCRs) are important pharmaceutical targets. Knowledge of their 3D structures is critical to understanding mechanisms of drug action. Low cellular expression, purification yield, and in vitro instability are substantial h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::69faa07be6b906e77e970d6c8b93992b
https://doi.org/10.1038/s41596-019-0259-y
https://doi.org/10.1038/s41596-019-0259-y
Autor:
Martin, Audet, Kelly, Villers, Jeffrey, Velasquez, Meihua, Chu, Chris, Hanson, Raymond C, Stevens
Publikováno v:
Nature protocols. 15(1)
G protein-coupled receptors (GPCRs) are important pharmaceutical targets. Knowledge of their 3D structures is critical to understanding mechanisms of drug action. Low cellular expression, purification yield, and in vitro instability are substantial h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::ab39af87d6dc2aaba903f1809fe6b036
https://pubmed.ncbi.nlm.nih.gov/31784719
https://pubmed.ncbi.nlm.nih.gov/31784719
Autor:
Kate L. White, Vsevolod Katritch, Billy Breton, Martin Audet, Wei Liu, Uwe Weierstall, Wenqing Shui, David Manahan, Barbara Zarzycka, Yan Lu, Raymond C. Stevens, Michael A. Hanson, Vadim Cherezov, Alexander Batyuk, Jeffrey Velasquez, Petr Popov, Cornelius Gati, Gye Won Han, Hao Hu
Publikováno v:
Nature chemical biology
Misoprostol is a life-saving drug in many developing countries for women at risk of post-partum hemorrhaging owing to its affordability, stability, ease of administration and clinical efficacy. However, misoprostol lacks receptor and tissue selectivi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ffa07a0dde83d1240b1495d79f578075
https://pubmed.ncbi.nlm.nih.gov/30573766
https://pubmed.ncbi.nlm.nih.gov/30573766
Autor:
Shinji Nakade, Hirotaka Mizuno, Christopher B. Roth, Raymond C. Stevens, Mauro Mileni, Dora Warshaviak, Guillermo Asmar-Rovira, Caroline Rodgers, Jerold Chun, Michael A. Hanson, Gye Won Han, Rie Omi, Jeffrey Velasquez, Mark T. Griffith, Haruto Kurata, Masahiko Terakado, Yasuyuki Kihara, Jill E. Chrencik
Publikováno v:
Cell. 161(7):1633-1643
SummaryLipid biology continues to emerge as an area of significant therapeutic interest, particularly as the result of an enhanced understanding of the wealth of signaling molecules with diverse physiological properties. This growth in knowledge is e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b22edcb5a06396fd07a460c9c3437433
Autor:
Ellen Y.T. Chien, Christopher B. Roth, Mark Yeager, Raymond C. Stevens, Michael A. Hanson, Yuanzi Hua, Kin Moy, Mark T. Griffith, Kent A. Baker, Jeffrey Velasquez, Sam Ellis, Alexei Brooun, Leila K. Davis, Alexander I. Alexandrov, Peter Kuhn, Veli-Pekka Jaakola, Barbie K. Ganser-Pornillos
Publikováno v:
Protein Expression and Purification. 56:85-92
Production of structure-grade mammalian membrane proteins in substantial quantities has been hindered by a lack of methods for effectively profiling multiple constructs expression in higher eukaryotic systems such as insect or mammalian cells. To add
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64e4f5a9148d27d10f3b92b2be9493da
https://doi.org/10.1016/j.pep.2007.06.003
https://doi.org/10.1016/j.pep.2007.06.003
Autor:
Peter Kuhn, Raymond C. Stevens, Alexei Brooun, Vanitha Subramanian, Jeremiah S. Joseph, Jeffrey Velasquez, Mark T. Griffith, Kumar Singh Saikatendu, Kin Moy, Michael J. Buchmeier, Maneesh K. Yadav, Benjamin W. Neuman
Publikováno v:
Journal of Virology
The severe acute respiratory syndrome coronavirus (SARS-CoV) possesses a large 29.7-kb positive-stranded RNA genome. The first open reading frame encodes replicase polyproteins 1a and 1ab, which are cleaved to generate 16 “nonstructural” proteins
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a8a38ae7862495211a1133a6c34b71b5
https://doi.org/10.1128/jvi.00467-06
https://doi.org/10.1128/jvi.00467-06
Autor:
Tom Clayton, Raymond C. Stevens, Mark T. Griffith, Vanitha Subramanian, Benjamin W. Neuman, Michael J. Buchmeier, Jeremiah S. Joseph, Kin Moy, Peter Kuhn, Jeffrey Velasquez, Kumar Singh Saikatendu
Publikováno v:
Structure (London, England : 1993)
Structure (London, England : 1993), vol 13, iss 11
Structure (London, England : 1993), vol 13, iss 11
The crystal structure of a conserved domain of nonstructural protein 3 (nsP3) from severe acute respiratory syndrome coronavirus (SARS-CoV) has been solved by single-wavelength anomalous dispersion to 1.4 A resolution. The structure of this "X" domai
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::347a106b53be991a8187dd1be5d4c49e
https://pubmed.ncbi.nlm.nih.gov/16271880
https://pubmed.ncbi.nlm.nih.gov/16271880
Autor:
Raymond C. Stevens, Rebecca Page, Eric Sims, Jeffrey Velasquez, Kin Moy, Carina Grittini, Brendan McManus, Thomas Clayton
Publikováno v:
BioTechniques. 37(3)
Micro-Expression Device for Protein Expression Large-scale recombinant protein expression and purification technologies for use in structural studies are time-consuming and expensive. Small-scale s...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f805d01d6ab5c0f234038e9cbb732cd
https://pubmed.ncbi.nlm.nih.gov/15470889
https://pubmed.ncbi.nlm.nih.gov/15470889