Zobrazeno 1 - 10
of 45
pro vyhledávání: '"Jeffrey V. May"'
Autor:
Viktor Y. Butnev, Jeffrey V. May, Alan R. Brown, Tarak Sharma, Vladimir Y. Butnev, William K. White, David J. Harvey, George R. Bousfield
Publikováno v:
Frontiers in Endocrinology, Vol 13 (2022)
Follicle-stimulating hormone (FSH), an α/β heterodimeric glycoprotein hormone, consists of functionally significant variants resulting from the presence or absence of either one of two FSHβ subunit N-glycans. The two most abundant variants are ful
Externí odkaz:
https://doaj.org/article/65e5a5b4f54b4fa0b40688d3cc45d7e8
In Vivo and In Vitro Impact of Carbohydrate Variation on Human Follicle-Stimulating Hormone Function
Publikováno v:
Frontiers in Endocrinology, Vol 9 (2018)
Human follicle-stimulating hormone (FSH) exhibits both macro- and microheterogeneity in its carbohydrate moieties. Macroheterogeneity results in three physiologically relevant FSHβ subunit variants, two that possess a single N-linked glycan at eithe
Externí odkaz:
https://doaj.org/article/52233f27874347be845f7a1b63d3c981
Autor:
Haley R. Blum, Jeffrey V. May, Alan Brown, Gillian P. Johnson, Guohua Hua, Viktor Y. Butnev, Jitu W. George, Sahithi Katta, John S. Davis, Chittibabu Guda, Xiaoying Hou, Kendra L. Clark, Siddesh Southekal, Kim Jonas, James D. Eudy, George R. Bousfield
Publikováno v:
Hum Reprod
STUDY QUESTION Does hypo-glycosylated human recombinant FSH (hFSH18/21) have greater in vivo bioactivity that drives follicle development in vivo compared to fully-glycosylated human recombinant FSH (hFSH24)? SUMMARY ANSWER Compared with fully-glycos
Autor:
George R. Bousfield, Jitu W. George, Haley R. Blum, Xiaoying Hou, Aixin Liang, Michele R. Plewes, John S. Davis, Emilia Przygrodzka, Jeffrey V. May, Kendra L. Clark, Guohua Hua, Viktor Y. Butnev
Publikováno v:
Mol Cell Endocrinol
Previous studies have reported hypo-glycosylated FSH and fully-glycosylated FSH to be naturally occurring in humans, and these glycoforms exist in changing ratios over a woman's lifespan. The precise cellular and molecular effects of recombinant huma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4f7f0c0cbe7191b912ee687dfcee011
https://europepmc.org/articles/PMC7418035/
https://europepmc.org/articles/PMC7418035/
Autor:
Jacob May, Jeffrey V. May, Huizhen Wang, T. Rajendra Kumar, Bin Shuai, Viktor Y. Butnev, George R. Bousfield
Publikováno v:
Molecular and Cellular Endocrinology. 437:224-236
The hormone - specific FSHβ subunit of the human FSH heterodimer consists of N-linked glycans at Asn7 and Asn24 residues that are co-translationally attached early during subunit biosynthesis. Differences in the number of N-glycans (none, one or two
Autor:
Vladimir Y. Butnev, George R. Bousfield, David Harvey, Yasuaki Hiromasa, Jeffrey V. May, Viktor Y. Butnev
Publikováno v:
Molecular and Cellular Endocrinology. 382:989-997
Hypo-glycosylated hFSH(21/18) (possesses FSHβ(21) and FSHβ(18)bands) was isolated from hLH preparations by immunoaffinity chromatography followed by gel filtration. Fully-glycosylated hFSH(24) was prepared by combining the fully-glycosylated FSHβ(
Autor:
Wendell W. Leavitt, Isabel R. Hendry, Shyamal K. Roy, William J. Hendry, Imala D. Alwis, Jeffrey V. May, Dulce M. Maroni
Publikováno v:
Reproductive Toxicology. 32:472-483
We assessed neonatal diethylstilbestrol (DES)-induced disruption at various endocrine levels in the hamster. In particular, we used organ transplantation into the hamster cheek pouch to determine whether abnormalities observed in the post-pubertal ov
Autor:
Jeffrey V. May, Xiaoying Hou, Cheng Wang, Chao Jiang, John S. Davis, George R. Bousfield, Viktor Y. Butnev
Publikováno v:
The Journal of clinical endocrinology and metabolism. 100(6)
Previous studies suggest that aging in women is associated with a reduction in hypoglycosylated forms of FSH.Experiments were performed to determine whether glycosylation of the FSHβ subunit modulates the biological activity of FSH in human granulos
Publikováno v:
Journal of glycomics & lipidomics
Follicle-stimulating hormone (FSH) is a member of the glycoprotein hormone family, which is a subfamily of the cystine knot growth factor superfamily [1,2]. The glycoprotein hormones are composed of heterodimeric glycoprotein subunits, a common α-su
Publikováno v:
The FASEB Journal. 29