Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Jeffrey Tredup"'
Autor:
Gregory A, Locke, Jodi, Muckelbauer, John S, Tokarski, Christopher M, Barbieri, Stefan, Belić, Bradley, Falk, Jeffrey, Tredup, Ying-Kai, Wang
Publikováno v:
Methods in enzymology. 667
Kinase inhibition continues to be a major focus of pharmaceutical research and discovery due to the central role of these proteins in the regulation of cellular processes. One family of kinases of pharmacological interest, due to its role in activati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::caab039749ff8148578fbf0f17125bd8
https://pubmed.ncbi.nlm.nih.gov/35525559
https://pubmed.ncbi.nlm.nih.gov/35525559
Autor:
Gregory A. Locke, Jodi Muckelbauer, John S. Tokarski, Christopher M. Barbieri, Stefan Belić, Bradley Falk, Jeffrey Tredup, Ying-Kai Wang
Publikováno v:
Methods in Enzymology ISBN: 9780323915410
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0f1fcafaa9f16795bca7c80dddcc9f17
https://doi.org/10.1016/bs.mie.2022.03.051
https://doi.org/10.1016/bs.mie.2022.03.051
Autor:
Yanlei Zhang, Jeffrey Tredup, Mertzman Michael E, Nelly Aranibar, Kim W. McIntyre, Kathleen M. Gillooly, Jodi K. Muckelbauer, James R. Burke, Lihong Cheng, Joann Strnad, Celia D’Arienzo, Dawn Mulligan, Stephen T. Wrobleski, Charu Chaudhry, Adriana Zupa-Fernandez, Percy H. Carter, Dianlin Xie, Manoj Chiney, Elizabeth M. Heimrich, Moslin Ryan M, Christine Huang, Xiaoxia Yang, Shuqun Lin, David S. Weinstein, Tokarski John S, Chiehying Chang, Louis J. Lombardo, Huadong Sun, Steven H. Spergel
Publikováno v:
Journal of Medicinal Chemistry. 62:8953-8972
As a member of the Janus (JAK) family of nonreceptor tyrosine kinases, TYK2 plays an important role in mediating the signaling of pro-inflammatory cytokines including IL-12, IL-23, and type 1 interferons. The nicotinamide 4, identified by a SPA-based
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7ce72d9f5c30b5b21e9d4c5dd0ac4218
https://doi.org/10.1021/acs.jmedchem.9b00443
https://doi.org/10.1021/acs.jmedchem.9b00443
Autor:
Charu Chaudhry, Percy H. Carter, Moslin Ryan M, Celia D’Arienzo, James Lin, Jodi K. Muckelbauer, Luisa Salter-Cid, Tracy L. Taylor, Kim W. McIntyre, Chunjian Liu, James R. Burke, Paul A. Elzinga, Hyunsoo Park, Kathleen M. Gillooly, Chiehying Chang, Dianlin Xie, Jing Chen, Lihong Cheng, David S. Weinstein, Cliff Chen, Jeffrey Tredup, Huadong Sun, Peng Li, Louis J. Lombardo, Adriana Zupa-Fernandez, Joann Strnad, John S. Tokarski, Dauh-Rurng Wu, Nelly Aranibar
Publikováno v:
ACS Medicinal Chemistry Letters. 10:383-388
In sharp contrast to a previously reported series of 6-anilino imidazopyridazine based Tyk2 JH2 ligands, 6-((2-oxo-N1-substituted-1,2-dihydropyridin-3-yl)amino)imidazo[1,2-b]pyridazine analogs were found to display dramatically improved metabolic sta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c61bca62d250bf5db34601de42b3c25b
https://doi.org/10.1021/acsmedchemlett.9b00035
https://doi.org/10.1021/acsmedchemlett.9b00035
Autor:
Dianlin Xie, Jing Chen, Celia D’Arienzo, Jodi K. Muckelbauer, Nelly Aranibar, John S. Sack, Jeffrey Tredup, Christine Huang, Charu Chaudhry, Joann Strnad, Percy H. Carter, John S. Tokarski, Adriana Zupa-Fernandez, Joseph B. Santella, Yuval Blat, Gardner Daniel S, James R. Burke, James Lin, David S. Weinstein, Moslin Ryan M, Yifan Zhang, Lihong Cheng, Chong-Hwan Chang, Donna L. Pedicord, Chunjian Liu, J. V. Duncia, Huadong Sun
Publikováno v:
MedChemComm. 8:700-712
As a member of the Janus (JAK) family of non-receptor tyrosine kinases, TYK2 mediates the signaling of pro-inflammatory cytokines including IL-12, IL-23 and type 1 interferon (IFN), and therefore represents an attractive potential target for treating
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::552547d736fc9e5ccc4dd8b6c4e38854
https://doi.org/10.1039/c6md00560h
https://doi.org/10.1039/c6md00560h
Autor:
Max Ruzanov, David J. Shuster, Manoj Chiney, Kim W. McIntyre, James R. Burke, Celia D’Arienzo, Nelly Aranibar, Elizabeth M. Heimrich, Louis J. Lombardo, Dianlin Xie, Moslin Ryan M, Joann Strnad, Anjaneya Chimalakonda, Lihong Cheng, James Kempson, Adriana Zupa-Fernandez, Javed Khan, Charu Chaudhry, Huadong Sun, Shuqun Lin, Percy H. Carter, Steven H. Spergel, Christine Huang, Dawn Mulligan, Stephen T. Wrobleski, Kathleen M. Gillooly, Yanlei Zhang, Jeffrey Tredup, David S. Weinstein, Tokarski John S, William J. Pitts, Xiaoxia Yang
Publikováno v:
Journal of medicinal chemistry. 62(20)
Small molecule JAK inhibitors have emerged as a major therapeutic advancement in treating autoimmune diseases. The discovery of isoform selective JAK inhibitors that traditionally target the catalytically active site of this kinase family has been a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74a281427643b3f6489276fb5c4ffe37
https://pubmed.ncbi.nlm.nih.gov/31603320
https://pubmed.ncbi.nlm.nih.gov/31603320
Autor:
Ryan, Moslin, Yanlei, Zhang, Stephen T, Wrobleski, Shuqun, Lin, Michael, Mertzman, Steven, Spergel, John S, Tokarski, Joann, Strnad, Kathleen, Gillooly, Kim W, McIntyre, Adriana, Zupa-Fernandez, Lihong, Cheng, Huadong, Sun, Charu, Chaudhry, Christine, Huang, Celia, D'Arienzo, Elizabeth, Heimrich, Xiaoxia, Yang, Jodi K, Muckelbauer, ChiehYing, Chang, Jeffrey, Tredup, Dawn, Mulligan, Dianlin, Xie, Nelly, Aranibar, Manoj, Chiney, James R, Burke, Louis, Lombardo, Percy H, Carter, David S, Weinstein
Publikováno v:
Journal of medicinal chemistry. 62(20)
As a member of the Janus (JAK) family of nonreceptor tyrosine kinases, TYK2 plays an important role in mediating the signaling of pro-inflammatory cytokines including IL-12, IL-23, and type 1 interferons. The nicotinamide
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a6a5ff3f143a4460f1c63e1a663ab705
https://pubmed.ncbi.nlm.nih.gov/31314518
https://pubmed.ncbi.nlm.nih.gov/31314518
Autor:
Chunjian, Liu, James, Lin, Ryan, Moslin, John S, Tokarski, Jodi, Muckelbauer, ChiehYing, Chang, Jeffrey, Tredup, Dianlin, Xie, Hyunsoo, Park, Peng, Li, Dauh-Rurng, Wu, Joann, Strnad, Adriana, Zupa-Fernandez, Lihong, Cheng, Charu, Chaudhry, Jing, Chen, Cliff, Chen, Huadong, Sun, Paul, Elzinga, Celia, D'arienzo, Kathleen, Gillooly, Tracy L, Taylor, Kim W, McIntyre, Luisa, Salter-Cid, Louis J, Lombardo, Percy H, Carter, Nelly, Aranibar, James R, Burke, David S, Weinstein
Publikováno v:
ACS medicinal chemistry letters. 10(3)
[Image: see text] In sharp contrast to a previously reported series of 6-anilino imidazopyridazine based Tyk2 JH2 ligands, 6-((2-oxo-N1-substituted-1,2-dihydropyridin-3-yl)amino)imidazo[1,2-b]pyridazine analogs were found to display dramatically impr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::4e6afd2505827dbe54bba056d0f57dd8
https://pubmed.ncbi.nlm.nih.gov/30891145
https://pubmed.ncbi.nlm.nih.gov/30891145
Autor:
Hua Fang, Kevin Kish, Mark R. Witmer, Matthew G. Soars, Kyle Parcella, Brett R. Beno, Ying-Kai Wang, Prakash Anjanappa, Julie A. Lemm, Karen Rigat, Katherine A. Grant-Young, Kap-Sun Yeung, Kathy Mosure, Steven Sheriff, Kenneth S. Santone, Jeffrey Tredup, Dawn D. Parker, John F. Kadow, Rajesh Onkardas Bora, Mengping Liu, Nicholas A. Meanwell, Susan B. Roberts, Adam G. Jardel, Rudolph G. Krause, Juliang Zhu, Kumaravel Selvakumar, Roy Haskell
[Image: see text] In solving the P-gp and BCRP transporter-mediated efflux issue in a series of benzofuran-derived pan-genotypic palm site inhibitors of the hepatitis C virus NS5B replicase, it was found that close attention to physicochemical proper
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b87c17f58394ad90d7b8ea7bef1817f
https://europepmc.org/articles/PMC6295864/
https://europepmc.org/articles/PMC6295864/
Autor:
Alan Xiangdong Wang, Andrew C. Good, Fei Yu, Peter Hrnciar, Herbert E. Klei, Manjula Paruchuri, Fiona McPhee, Dennis Hernandez, Paul Falk, Jeffrey Tredup, Amy K. Sheaffer, Qi Gao, Barbara Zheng, Kevin Kish, Kathy Mosure, Stanley D'andrea, Ramkumar Rajamani, Alicia Ng, Jay O. Knipe, Yan Chen, Li-Qiang Sun, Jacques Friborg, Paul Michael Scola, Arvind Mathur, Nicholas A. Meanwell, Richard Rampulla
The design and synthesis of potent, tripeptidic acylsulfonamide inhibitors of HCV NS3 protease that contain a difluoromethyl cyclopropyl amino acid at P1 are described. A cocrystal structure of 18 with a NS3/4A protease complex suggests the presence
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::deb2005e8a0764575ac7a4f49607aedd
https://europepmc.org/articles/PMC5807875/
https://europepmc.org/articles/PMC5807875/