Zobrazeno 1 - 10
of 44
pro vyhledávání: '"Jeffrey Tom"'
Autor:
Alix I Chan, Manali S. Sawant, Daniel J. Burdick, Jeffrey Tom, Aimin Song, Christian N. Cunningham
Publikováno v:
ACS chemical biology.
Advances in genetic code reprogramming have allowed the site-specific incorporation of noncanonical functionalities into polypeptides and proteins, providing access to wide swaths of chemical space via
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16cf6e4c3b29b6e1dc433975d6e06a79
https://pubmed.ncbi.nlm.nih.gov/36607609
https://pubmed.ncbi.nlm.nih.gov/36607609
Autor:
Raidizon Mercedes, Dennis Head, Elizabeth Zook, Eric Eidelman, Jeffrey Tomaszewski, Serge Ginzburg, Robert Uzzo, Marc Smaldone, John Danella, Thomas J. Guzzo, Daniel Lee, Laurence Belkoff, Jeffrey Walker, Adam Reese, Mihir S. Shah, Bruce Jacobs, Jay D. Raman
Publikováno v:
Current Oncology, Vol 31, Iss 8, Pp 4746-4752 (2024)
Imaging for prostate cancer defines the extent of disease. Guidelines recommend against imaging low-risk prostate cancer patients with a computed tomography (CT) scan or bone scan due to the low probability of metastasis. We reviewed imaging performe
Externí odkaz:
https://doaj.org/article/5ebd374560c94c42b184f9883712b0ef
Autor:
Yue Fu, Wenqiong Wu, Sayumi Yamazoe, Changlei Sun, Liang Zeng, Qi Liu, Wayne J. Fairbrother, Jie Lin, Kui Lin, Jeffrey Tom, Steven T. Staben
Publikováno v:
Journal of Medicinal Chemistry. 63:2807-2813
Heterobifunctional molecules have proven powerful tools to induce ligase-dependent ubiquitination of target proteins. We describe here a chemical strategy for controlling a different post-translational modification (PTM): phosphorylation. Heterobifun
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2226bb9c44ac0e26374ca3cc5264011
https://doi.org/10.1021/acs.jmedchem.9b01167
https://doi.org/10.1021/acs.jmedchem.9b01167
Autor:
Jérémie Decalf, Jeffrey Tom, Elaine Mai, Hilda Hernandez-Barry, Cameron L. Noland, Breanna S. Vollmar, Alice Li, Hong Li, Daniel Xie, Lunchao Zhu, Jian Payandeh, Kelly M. Loyet, Cong Wu, Laetitia Comps-Agrar, Christine Moussion, Matthew L. Albert, Aimin Song
Publikováno v:
Bioorganic Chemistry. 120:105655
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::325b6009dadec4cd5f94c52b2d5e05ea
https://doi.org/10.1016/j.bioorg.2022.105655
https://doi.org/10.1016/j.bioorg.2022.105655
Autor:
Hilda Hernandez-Barry, Jérémie Decalf, Hong Li, Cameron L. Noland, Alice Li, Elaine Mai, Jian Payandeh, Daniel Xie, Laetitia Comps-Agrar, Lunchao Zhu, Aimin Song, Cong Wu, Matthew L. Albert, Jeffrey Tom, Breanna S. Vollmar, Christine Moussion
Publikováno v:
Bioorganic Chemistry. 116:105376
Antitumor immune responses depend on the infiltration of solid tumors by effector T cells, a process guided by chemokines. In particular, the chemokine CXCL10 has been shown to play a critical role in mediating recruitment of CXCR3 + cytolytic T and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c1496c45fbc1fcf15dcda7afeb16abb
https://doi.org/10.1016/j.bioorg.2021.105376
https://doi.org/10.1016/j.bioorg.2021.105376
Autor:
Yue Zhang, Saundra Clausen, James J. Crawford, Thjis J. Hagenbeek, Hong C. Shen, Cameron L. Noland, Jeffrey Tom, Wendy Lee, Jeffrey K. Holden, Christian N. Cunningham, Rina Fong, Hu Taishan, Rohit Reja, Zheng Zhou, Micah Steffek, Paul Beroza, Stephen Schmidt, Richard Zang, Jason R. Zbieg, Gregory M. Miller, Jennifer A. Lacap
Publikováno v:
Cell Reports. 31:107809
The transcriptional enhanced associate domain (TEAD) family of transcription factors serves as the receptors for the downstream effectors of the Hippo pathway, YAP and TAZ, to upregulate the expression of multiple genes involved in cellular prolifera
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7fb778f3e552df2799b44e945abb67d3
https://doi.org/10.1016/j.celrep.2020.107809
https://doi.org/10.1016/j.celrep.2020.107809
Autor:
Priscilla Ahwin, BS, Anthony Santisi, MD, Gord Guo Zhu, MD, MS, PhD, Jeffrey Tomaszewski, MD, Mark DiMarcangelo, DO, MS
Publikováno v:
Radiology Case Reports, Vol 18, Iss 1, Pp 31-36 (2023)
Paratesticular leiomyosarcoma is a rare malignant tumor deriving from the smooth muscle of structures surrounding the testes, including the epididymis or scrotum. With few cases of genitourinary soft tissue sarcomas reported in the literature, little
Externí odkaz:
https://doaj.org/article/1f36527c42164affa5ca63507d6c40ee
Autor:
Kyle E. Landgraf, Clifford Quan, Charles Eigenbrot, Henry R. Maun, Jeffrey Tom, Micah Steffek, Lydia Santell, Robert A. Lazarus, Christine Yu
Publikováno v:
Nature Chemical Biology. 10:567-573
Stimulation of hepatocyte growth factor (HGF) signaling through the Met receptor is an attractive approach for promoting tissue repair and preventing fibrosis. Using structure-guided peptide phage display combined with an activity-based sorting strat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::992c32e8e785177f93b9df39f597910b
https://doi.org/10.1038/nchembio.1533
https://doi.org/10.1038/nchembio.1533
Autor:
Clifford Quan, Paul Moran, Daniel Kirchhofer, Wei Li, Paola Di Lello, Charles Eigenbrot, Andrew S. Peterson, Steven Shia, Jeffrey Tom, Monica Kong-Beltran, Yingnan Zhang, Lijuan Zhou, Nicholas J. Skelton
Publikováno v:
Journal of Biological Chemistry. 289:942-955
PCSK9 (proprotein convertase subtilisin/kexin type 9) is a negative regulator of the hepatic LDL receptor, and clinical studies with PCSK9-inhibiting antibodies have demonstrated strong LDL-c-lowering effects. Here we screened phage-displayed peptide
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ebf82b7a53e92e51dbeda44fe967b2e3
https://doi.org/10.1074/jbc.m113.514067
https://doi.org/10.1074/jbc.m113.514067