Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Jeffrey T. Mindrebo"'
Autor:
Laetitia E. Misson Mindrebo, Jeffrey T. Mindrebo, Quoc Tran, Mark C. Wilkinson, Jessica M. Smith, Megan Verma, Nicholas R. Casewell, Gabriel C. Lander, Joseph G. Jardine
Publikováno v:
Toxins, Vol 16, Iss 8, p 361 (2024)
Snake venoms are cocktails of biologically active molecules that have evolved to immobilize prey, but can also induce a severe pathology in humans that are bitten. While animal-derived polyclonal antivenoms are the primary treatment for snakebites, t
Externí odkaz:
https://doaj.org/article/50e022fa1a7441a6b54a54493eb0306b
Autor:
Mia Shin, Edmond R. Watson, Albert S. Song, Jeffrey T. Mindrebo, Scott J. Novick, Patrick R. Griffin, R. Luke Wiseman, Gabriel C. Lander
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
The human mitochondrial protease LONP1 is an AAA+ ATP-dependent quality control protease. Here, the authors present the cryo-EM structures of human LONP1 in three distinct states and provide insights into the mechanism and regulation of this importan
Externí odkaz:
https://doaj.org/article/bb66b8ea8165482a8ae94b393309ce0d
Autor:
Jeffrey T. Mindrebo, Ashay Patel, Woojoo E. Kim, Tony D. Davis, Aochiu Chen, Thomas G. Bartholow, James J. La Clair, J. Andrew McCammon, Joseph P. Noel, Michael D. Burkart
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
The formation of C-C bonds in fatty acid and polyketide biosynthesis depends on β-ketoacyl-acyl carrier protein (ACP) synthases (KSs). Here, the authors present structures of E.coli KSs bound to substrate mimetic bearing ACPs, providing insights int
Externí odkaz:
https://doaj.org/article/8b2f324577e8467b8bb69a969b0ffd83
Autor:
Aochiu Chen, Jeffrey T. Mindrebo, Tony D. Davis, Woojoo E. Kim, Yohei Katsuyama, Ziran Jiang, Yasuo Ohnishi, Joseph P. Noel, Michael D. Burkart
Publikováno v:
Acta crystallographica. Section D, Structural biology. 78(Pt 9)
Ketosynthases (KSs) catalyse essential carbon–carbon bond-forming reactions in fatty-acid biosynthesis using a two-step, ping-pong reaction mechanism. In Escherichia coli, there are two homodimeric elongating KSs, FabB and FabF, which possess overl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09ddac663ab6c89e806b5195c14705f5
https://pubmed.ncbi.nlm.nih.gov/36048156
https://pubmed.ncbi.nlm.nih.gov/36048156
Autor:
Aochiu Chen, Jeffrey T. Mindrebo, Tony D. Davis, Woojoo E. Kim, Yohei Katsuyama, Ziran Jiang, Yasuo Ohnishi, Joseph P. Noel, Michael D. Burkart
Ketosynthases (KS) catalyse essential carbon-carbon bond forming reactions in fatty acid biosynthesis using a two-step, ping-pong reaction mechanism. In E. coli, there are two homodimeric elongating KSs, FabB and FabF, both of which possess overlappi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::22b6f1dac41ec51eb2215919587db698
https://doi.org/10.1101/2022.04.04.486996
https://doi.org/10.1101/2022.04.04.486996
Autor:
Joseph P. Noel, Ashay Patel, J. Andrew McCammon, Tony D. Davis, Jeffrey T. Mindrebo, Michael D. Burkart, Laëtitia Misson
Publikováno v:
Proceedings of the National Academy of Sciences. 117:24224-24233
Fatty acid synthases (FASs) and polyketide synthases (PKSs) iteratively elongate and often reduce two-carbon ketide units in de novo fatty acid and polyketide biosynthesis. Cycles of chain extensions in FAS and PKS are initiated by an acyltransferase
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cae7f23aab9bcb82fca006391868f6ff
https://doi.org/10.1073/pnas.2009805117
https://doi.org/10.1073/pnas.2009805117
Publikováno v:
Biochemistry
Elongating ketosynthases (KSs) catalyze carbon-carbon bond-forming reactions during the committed step for each round of chain extension in both fatty acid synthases (FASs) and polyketide synthases (PKSs). A small α-helical acyl carrier protein (ACP
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af9d35d8065a35c9cb6654f8cda14995
https://doi.org/10.1021/acs.biochem.0c00605
https://doi.org/10.1021/acs.biochem.0c00605
Autor:
Ashay Patel, Jeffrey T. Mindrebo, Laetitia E. Misson, James A. McCammon, Joseph P. Noel, Michael D. Burkart
Publikováno v:
Biophysical Journal. 122:328a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::96e73e75e87b1478a6b9dff916a2ce92
https://doi.org/10.1016/j.bpj.2022.11.1832
https://doi.org/10.1016/j.bpj.2022.11.1832
Autor:
Jeffrey T. Mindrebo, Aochiu Chen, Woojoo E. Kim, Rebecca N. Re, Tony D. Davis, Joseph P. Noel, Michael D. Burkart
Publikováno v:
ACS Catal
Ketosynthases (KSs) catalyze carbon-carbon bond forming reactions in fatty acid synthases (FASs) and polyketide synthases (PKSs). KSs utilize a two-step ping pong kinetic mechanism to carry out an overall decarboxylative thio-Claisen condensation tha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2fe1cb1dc8d76dc847171902e6bdcee6
https://europepmc.org/articles/PMC9524369/
https://europepmc.org/articles/PMC9524369/
Autor:
Aochiu Chen, Michael D. Burkart, Jeffrey T. Mindrebo, Joseph P. Noel, Tony D. Davis, Rebecca N. Re, Woojoo E. Kim
Ketosynthases (KSs) catalyze carbon-carbon bond forming reactions in fatty acid synthases (FASs) and polyketide synthases (PKSs). KSs utilize a two-step ping pong kinetic mechanism to carry out an overall decarboxylative thio-Claisen condensation tha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f18dd97b5b465f22011ab467b06e1c22
https://doi.org/10.1101/2021.02.13.431092
https://doi.org/10.1101/2021.02.13.431092