Výsledky vyhledávání - "Jeffrey T. Laydon"

Amphibian Melanophore Technology as a Functional Screen for Antagonists of G-Protein Coupled 7-Transmembrane Receptors

Autor: Fei-Lan Wang, Randall K. Johnson, Paul R. Murdock, Alison M. Badger, Jeffrey T. Laydon, Bradford C. Van Wagenen, Gary R. Pettman, Maxine Gowen, Jonathan A. Lee, Ashu Parihar, Glenn A. Hofmann, John Fox, Michael R. Mattern, Mark Nuttall, John C. Lee

Publikováno v: SLAS Discovery. 4:269-277

Xenopus laevis melanophores stably expressing 7-transmembrane G-protein-coupled receptors were established and evaluated, either as a primary screening utility for antagonists of the human calcium receptor, or as a screen to assign function to bindin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ed308d7fb3778ed8dcfdd9c77060b60
https://doi.org/10.1177/108705719900400508

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1-Substituted 4-Aryl-5-pyridinylimidazoles: A New Class of Cytokine Suppressive Drugs with Low 5-Lipoxygenase and Cyclooxygenase Inhibitory Potency

Autor: Jeremy Bradbeer, Margaret E. Sorenson, Jerry L. Adams, Marie Chabot-Fletcher, John J. Breton, Donald E. Griswold, Timothy Francis Gallagher, L. M. Hillegass, Alison M. Badger, Ravi Shanker Garigipati, Juanita M. Smietana, Peter L. Sheldrake, John C. Lee, Jeffrey T. Laydon, Jeffrey C. Boehm

Publikováno v: Journal of Medicinal Chemistry. 39:3929-3937

A series of 1-alkyl- or -aryl-4-aryl-5-pyridinylimidazoles (A) were prepared and tested for their ability to bind to a recently discovered protein kinase termed CSBP and to inhibit lipopolysaccharide (LPS)-stimulated TNF production in mice. The kinas

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7978f78e66ede571626a991f613937da
https://doi.org/10.1021/jm960415o

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2,4,5- triarylimidazole inhibitors of IL-1 biosynthesis

Autor: Paul Elliot Bender, Susan M. Fier-Thompson, Timothy Francis Gallagher, Ravi Shanker Garigipati, John J. Breton, Jeffrey T. Laydon, John C. Lee, Don E. Griswold, Juanita M. Smietana, Jerry L. Adams, Marie Chabot-Fletcher, Dennis Lee, Margaret E. Sorenson

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 5:1171-1176

As part of an effort to define the pharmacophore and discover the mechanism by which the antiinflammatory dual cyclooxygenase / 5-lipoxygenase inhibitors SK&F 86002 and SK&F 105809 inhibit IL-1 biosynthesis, a series of substituted 2,4,5-triarylimida

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::bf530aefbba7fd52abcababc28d8a55e
https://doi.org/10.1016/0960-894x(95)00189-z

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A protein kinase involved in the regulation of inflammatory cytokine biosynthesis

Autor: J. R. Heys, S. W. Landvatter, Joseph C. Lee, James E. Strickler, George P. Livi, Jerry L. Adams, Dean E. McNulty, Jeffrey T. Laydon, Sanjay Kumar, John R. White, I. R. Siemens, Timothy Gallagher, M. J. Blumenthal, David W. Green, Peter Young, Peter C. McDonnell, Megan M. McLaughlin, Seth M. Fisher

Publikováno v: Nature. 372:739-746

Production of interleukin-1 and tumour necrosis factor from stimulated human monocytes is inhibited by a new series of pyridinyl-imidazole compounds. Using radiolabelled and radio-photoaffinity-labelled chemical probes, the target of these compounds

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e24d7b582bf7042b4595ca6a9251e1cd
https://doi.org/10.1038/372739a0

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Evaluation of human cytokine production and effects of pharmacological agents in a heterologous system in vivo

Autor: Jeffrey T. Laydon, T.J. Torphy, J. O'Leary-Bartus, D.E. Griswold, L.M. Hillegass, J. C. Lee

Publikováno v: Journal of immunological methods. 195(1-2)

The ability of human monocytes adoptively transferred into the peritoneal cavity of BALB c mice to produce tumor necrosis factor-α (TNF) and interleukin 1β (IL-1) was studied. Human monocytes were isolated from fresh, heparinized blood obtained by

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e626ef7f74db7d35eb5a2ca92a66e34
https://pubmed.ncbi.nlm.nih.gov/8814313

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A modified assay for interleukin-1 (IL-1)

Autor: J. C. Lee, Jeffrey T. Laydon, Philip L. Simon

Publikováno v: Journal of immunological methods. 84(1-2)

A simple and reliable biological assay for interleukin-1 (IL-1) was developed, based on the production of interleukin-2 (IL-2) from the EL-4 murine T-cell lymphoma cell line, in the presence of 2–5 × 10−7 M calcium ionophore A23187. The assay wa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df7f14fb1ec8c46248303fa4a236f7fb
https://pubmed.ncbi.nlm.nih.gov/3934287

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