Zobrazeno 1 - 10
of 112
pro vyhledávání: '"Jeffrey T. J. Huang"'
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
Unresolved R-loops can represent a threat to genome stability. Here the authors reveal that DHX9 helicase can promote R-loop formation in the absence of splicing factors SFPQ and SF3B3.
Externí odkaz:
https://doaj.org/article/f6a6b01d7c104d91b1ab6b903aaebe70
Autor:
Ify R. Mordi, Rachael O. Forsythe, Corry Gellatly, Zaid Iskandar, Olivia M. McBride, Athanasios Saratzis, Rod Chalmers, Calvin Chin, Matthew J. Bown, David E. Newby, Chim C. Lang, Jeffrey T. J. Huang, Anna‐Maria Choy
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 8, Iss 20 (2019)
Background It is recognized that factors beyond aortic size are important in predicting outcome in abdominal aortic aneurysm (AAA) disease. AAA is characterized by the breakdown of elastin within the aortic tunica media, leading to aortic dilatation
Externí odkaz:
https://doaj.org/article/169adea789704ea68eabcee5009c9c54
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 16, p 5738 (2020)
Aberrant extracellular matrix (ECM) remodelling in muscle, liver and adipose tissue is a key characteristic of obesity and insulin resistance. Despite its emerging importance, the effective ECM targets remain largely undefined due to limitations of c
Externí odkaz:
https://doaj.org/article/1e89c72274164cf4a0564789d2bdd650
Publikováno v:
PPAR Research, Vol 2015 (2015)
Peroxisome proliferator activated receptors alpha (PPARα) and delta (PPARδ) belong to the nuclear receptor superfamily. PPARα is a target of well established lipid-lowering drugs. PPARδ (also known as PPARβ/δ) has been investigated as a promisi
Externí odkaz:
https://doaj.org/article/0dfe6640f4594d10afa023cd9f19ee12
Autor:
Kashan Ali, Muhammad Zubair Israr, Leong L. Ng, Ify Mordi, Chim C. Lang, Elena Kuzmanova, Jeffrey T-J Huang, Anna-Maria Choy
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 9 (2022)
BackgroundElastin degradation is implicated in the pathology of vulnerable plaque. Recent studies show promising results for plasma desmosine (pDES), an elastin-specific degradation product, as a marker of cardiovascular disease (CVD) outcomes. The a
Externí odkaz:
https://doaj.org/article/8662e3a32e87425fb9771ba8b54fd742
Autor:
Albena T. Dinkova-Kostova, Charlotte M. Proby, Tadashi Honda, Andrea L. Benedict, Sukirti Kalra, Akira Saito, Suqing Zheng, Rosemary Clarke, Jeffrey T.-J. Huang, James Ferguson, Robert S. Dawe, Paul Talalay, Jed W. Fahey, Maureen Higgins, Ying Zhang, Sally H. Ibbotson, Elena V. Knatko
The transcription factor Nrf2 determines the ability to adapt and survive under conditions of electrophilic, oxidative, and inflammatory stress by regulating the expression of elaborate networks comprising nearly 500 genes encoding proteins with vers
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69339df61a777f8d52704777198b5ebb
https://doi.org/10.1158/1940-6207.c.6544937
https://doi.org/10.1158/1940-6207.c.6544937
Autor:
Albena T. Dinkova-Kostova, Charlotte M. Proby, Tadashi Honda, Andrea L. Benedict, Sukirti Kalra, Akira Saito, Suqing Zheng, Rosemary Clarke, Jeffrey T.-J. Huang, James Ferguson, Robert S. Dawe, Paul Talalay, Jed W. Fahey, Maureen Higgins, Ying Zhang, Sally H. Ibbotson, Elena V. Knatko
Supplemental Figure S1. Spectral characteristics of UVA 340 lamps. Figure S2. Nrf2 disruption leads to an increase in the mRNA of Nrf3, but not Nrf1, in skin of SKH-1 hairless mice. Figure S3. TBE-31 treatment induces NQO1 in dermis and epidermis of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::471515a2418605a676187cbaa12c8627
https://doi.org/10.1158/1940-6207.22525847
https://doi.org/10.1158/1940-6207.22525847
Autor:
Alun Barton, William O.C.M. Cookson, Rebecca C Hull, Michael R. Loebinger, James D. Chalmers, Holly R. Keir, Huw Ellis, Jeffrey T.-J. Huang, Miriam F. Moffatt
Publikováno v:
Chest. 161:1180-1191
Nontuberculous mycobacterial (NTM) infections are difficult to diagnose and treat. Biomarkers to identify patients with active infection or at risk of disease progression would have clinical utility. Sputum is the most frequently used matrix for the
Autor:
C. Roland Wolf, Colin J. Henderson, Lesley A. McLaughlin, Jeffrey T.–J. Huang, De Lin, A. Kenneth MacLeod
Supplementary Table 1: MRM parameters for osimertinib, metabolites and internal standard. Supplementary Table 2. Correlation coefficients for formation of osimertinib metabolites. Supplementary Table 3. Metabolic phenotyping of osimertinib in pooled
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d2950936f04be3c883cf87f0289c278
https://doi.org/10.1158/1078-0432.22469784.v1
https://doi.org/10.1158/1078-0432.22469784.v1
Autor:
C. Roland Wolf, Colin J. Henderson, Lesley A. McLaughlin, Jeffrey T.–J. Huang, De Lin, A. Kenneth MacLeod
Purpose: Osimertinib is a third-generation inhibitor of the epidermal growth factor receptor used in treatment of non–small cell lung cancer. A full understanding of its disposition and capacity for interaction with other medications will facilitat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2de38d1349080112b5823ed687534a03
https://doi.org/10.1158/1078-0432.c.6527346.v1
https://doi.org/10.1158/1078-0432.c.6527346.v1