Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Jeffrey T. Emmick"'
Autor:
Simon Braat, Dean Patterson, Jeffrey T. Emmick, Thomas M. MacDonald, Margaret R. Warner, Robert A. Kloner, Mark B. Effron, Alun Bedding, Malcolm Mitchell
Publikováno v:
British Journal of Clinical Pharmacology. 60:459-468
Objective To investigate the effect of tadalafil on the time to exercise-induced myocardial ischaemia in subjects with coronary artery disease (CAD). Background CAD and erectile dysfunction (ED) share similar risk factors. It is important to know the
Autor:
Margaret R. Warner, Charles M. Beasley, Alex Dmitrienko, Arash Bakhtyari, Robert A. Kloner, Jeremy N. Ruskin, Malcolm I. Mitchell, Michael Turik, Wei Shen, Louis R. Cantilena, Alun Bedding, Timothy M. Costigan, Jeffrey T. Emmick
Publikováno v:
Journal of the American College of Cardiology. 46:678-687
ObjectivesThis study was designed to evaluate effects of tadalafil, a phosphodiesterase-5 inhibitor used for the treatment of erectile dysfunction (ED), on the QT interval.BackgroundCardiovascular disease is common in men with ED. Men with cardiovasc
Autor:
Jeffrey T. Emmick, R. Dustan Sarazan, Peter J. Sausen, Kenneth Michael Ferguson, William J. Crumb, Christine A. Strnat, Charles M. Beasley
Publikováno v:
European Journal of Pharmacology. 502:163-167
Compounds that inhibit phosphodiesterase 5 (PDE5) have been developed for the treatment of erectile dysfunction. Because men with erectile dysfunction frequently have comorbid cardiovascular disease, they may have limited cardiac repolarization reser
Publikováno v:
The Journal of Sexual Medicine. 1:161-167
Introduction Cardiovascular disease and erectile dysfunction (ED) share similar risk factors and often occur concomitantly. Therefore, men with ED may be at increased risk for cardiovascular adverse events. Aim The aim of this retrospective analysis
Autor:
Alexander von Keitz, Scott Segal, Jonathan Denne, Jeffrey T. Emmick, Daniel C. Lockhart, Charles M. Beasley, Aileen Murphy, Timothy M. Costigan, Jacob Rajfer
Publikováno v:
European Urology. 45:499-509
To assess patient preference for erectile dysfunction treatment between either sildenafil or tadalafil, each administered with their respective dosing instructions, and to evaluate preference for either sildenafil or tadalafil dosing instructions dur
Autor:
Robert A. Kloner, Graham Jackson, Malcolm I. Mitchell, Jonathan Denne, Adolph M. Hutter, Jeffrey T. Emmick
Publikováno v:
Journal of the American College of Cardiology. 42(10):1855-1860
ObjectivesThis study was designed to determine the time course of nitrate interaction with tadalafil, a phosphodiesterase 5 (PDE5) inhibitor with a half-life (t1/2) of 17.5 h.BackgroundThe PDE5 inhibitors augment the blood pressure (BP)-lowering effe
Publikováno v:
The American Journal of Cardiology. 92:37-46
To determine the effects of tadalafil on the cardiovascular system, safety assessments were performed on a database of4000 subjects who received tadalafil in60 clinical pharmacology, phase 2, phase 3, and open-label studies. In healthy subjects, tada
Autor:
Rod A. Humerickhouse, Henry R. Besch, Keshore R. Bidasee, Jeffrey T. Emmick, John L. Sutko, Koert Gerzon, Sangyeol Kwon, Luc Ruest
Publikováno v:
Journal of Biological Chemistry. 269:30243-30253
The plant alkaloids ryanodine and dehydroryanodine are specific and potent modulators of the sarcoplasmic reticulum calcium release channel. In the present study, acidic, basic, and neutral side chains esters of these diterpene compounds were prepare
Autor:
Koert Gerzon, Keshore R. Bidasee, Jeffrey T. Emmick, Rod A. Humerickhouse, Kurt T. Besch, Sangyeol Kwon, Henry R. Besch
Publikováno v:
Journal of Labelled Compounds and Radiopharmaceuticals. 34:33-47
A high affinity, photoactivatable, radio-iodinated ligand for the ryanodine binding site(s) of the sarcoplasmic reticulum calcium-release-channel, C10-Oeq-N-(4-azido-5-125iodo salicyloyl)-β-alanyl-β-alanyl ryanodine (Az-βAR), was synthesized at a
Autor:
Rod A. Humerickhouse, Keshore R. Bidasee, Jeffrey T. Emmick, Luc Ruest, Koert Gerzon, Roger W. Roeske, John L. Sutko, Henry R. Besch, Zhenping Tian
Publikováno v:
Journal of Medicinal Chemistry. 36:1319-1323
Amino- and guanidinoacyl esters of ryanodine were prepared to evaluate the effect of basicity on the binding affinity of these derivatives for the sarcoplasmic reticulum Ca(2+)-release channel (SR CRC). In the presence of DCC and DMAP Cbz-beta-alanin