Výsledky vyhledávání - "Jeffrey T. Dixon"

Dual Exosite-binding Inhibitors of Insulin-degrading Enzyme Challenge Its Role as the Primary Mediator of Insulin Clearance in Vivo

Publikováno v: Journal of Biological Chemistry. 290:20044-20059

Insulin-degrading enzyme (IDE, insulysin) is the best characterized catabolic enzyme implicated in proteolysis of insulin. Recently, a peptide inhibitor of IDE has been shown to affect levels of insulin, amylin, and glucagon in vivo. However, IDE(-/-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b79e6dcdb0455d21e4b543d83d06c40
https://doi.org/10.1074/jbc.m115.638205

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The discovery of a new structural class of cyclin-dependent kinase inhibitors, aminoimidazo[1,2-a]pyridines

Publikováno v: Molecular Cancer Therapeutics. 3:1-9

The protein kinase family represents an enormous opportunity for drug development. However, the current limitation in structural diversity of kinase inhibitors has complicated efforts to identify effective treatments of diseases that involve protein

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::24717723647ce63e0d3517c46f0c5ea2
https://doi.org/10.1158/1535-7163.1.3.1

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Synthesis of indole-ring fluorine-labeled analogs of LY333531, an isoform-selective inhibitor of protein kinase C

Autor: Peter G. Goekjian, Lawrence M. Ballas, Michael R. Jirousek, James W. White, Dale J. Thompson, John O. Cole, Jeffrey T. Dixon, Tamara P. Dudley, Priscilla Lugo-Mas, Stacy L. Cable

Publikováno v: Journal of Fluorine Chemistry. 98:137-142

Two fluorine-labeled analogs of LY333531, a potent, ATP-competitive, and isoform-selective inhibitor of protein kinase C-beta, have been prepared. 19 F-NMR labels were placed on the indole rings to probe for differences in the catalytic domains of th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6c1f94649270de64009b307bb122a302
https://doi.org/10.1016/s0022-1139(99)00095-0

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Synthesis of Fluorinated Macrocyclic Bis(indolyl)maleimides as Potential19F NMR Probes for Protein Kinase C

Autor: and Sean S. Chen, Lanxin Zhou, Jeffrey T. Dixon, Gillig James Ronald, Wu Guo-Zhang, Lawrence M. Ballas† and, Peter G. Goekjian, Michael R. Jirousek† and

Publikováno v: The Journal of Organic Chemistry. 64:4238-4246

Six macrocyclic bis(indolyl)maleimides 1−6 bearing a fluorine label on the aliphatic portion of the macrocycle have been prepared as potential fluorine NMR probes for the catalytic domain of protein kinase C. The macrocyclic bis(indolyl)maleimides

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b47c4d9890099c9045eb8508c75a9a38
https://doi.org/10.1021/jo9808876

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Virtual kinetics: Using statistical experimental design for rapid analysis of enzyme inhibitor mechanisms

Autor: Donna M. Daniels, Duane D. Bronson, Jeffrey T. Dixon, Catherine C. Redick, Perry D. Haaland

Publikováno v: Biochemical Pharmacology. 50:823-831

Modern automated drug-screening can generate hundreds of inhibitor leads from diverse chemical sources in a short period of time. Traditional methods of inhibitor analysis are resource intensive and limit the number of inhibitors that can be analyzed

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a286e5e91f89a00513a7eab82908ccd7
https://doi.org/10.1016/0006-2952(95)00206-f

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ChemInform Abstract: Synthesis of Fluorinated Macrocyclic Bis(indolyl)maleimides as Potential 19F NMR Probes for Protein Kinase C

Autor: Wu Guo-Zhang, Jeffrey T. Dixon, Lanxin Zhou, Peter G. Goekjian, James R. Gillig, Jirousek Michael R, Lawrence M. Ballas, Shi Chen

Publikováno v: ChemInform. 30

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::dc010d8b9a2d6e139fa06e4631eac412
https://doi.org/10.1002/chin.199938131

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ChemInform Abstract: Synthesis of Indole-Ring Fluorine-Labeled Analogues of LY333531, an Isoform-Selective Inhibitor of Protein Kinase C

Autor: Lawrence M. Ballas, Peter G. Goekjian, Tamara P. Dudley, Stacy L. Cable, James W. White, Jirousek Michael R, Jeffrey T. Dixon, Priscilla Lugo‐Mas, John Cole, Dale J. Thompson

Publikováno v: ChemInform. 30

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::dad8e60b53fbf023b54e279a888f2b7c
https://doi.org/10.1002/chin.199945198

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