Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Jeffrey T. Bagdanoff"'
Clearance of plasma PCSK9 via the asialoglycoprotein receptor mediated by heterobifunctional ligands
Autor:
Jeffrey T. Bagdanoff, Thomas M. Smith, Martin Allan, Peter O’Donnell, Zachary Nguyen, Elizabeth A. Moore, Jason Baird, Shuangxi Wang, Vanitha Subramanian, Bruno Tigani, David O. Nettleton, Lauren G. Monovich, Ian Lewis, Alec N. Flyer, Brian Granda, John W. Blankenship, David Barnes-Seeman, Kevin B. Clairmont
Publikováno v:
Cell Chemical Biology. 30:97-109.e9
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cda907f4423e41fe5feee324e9c215d0
https://doi.org/10.1016/j.chembiol.2022.12.003
https://doi.org/10.1016/j.chembiol.2022.12.003
Autor:
Victoriano Tamez, Brant Firestone, Michelle Fodor, Martin Sendzik, Michael G. Acker, Stan Spence, Matthew J. LaMarche, Mitsunori Kato, Chen Liu, Christopher Towler, Ping Wang, Ho Man Chan, Eric McNeill, Shumei Liu, Morvarid Mohseni, Sarah Williams, Zhouliang Chen, Gang Liu, Bing Yu, Robert Koenig, Huaixiang Hao, Ying-Nan Chen, Murphy Hentemann, Ritesh Bhanudasji Tichkule, Hongyun Wang, Jorge Garcia Fortanet, Laura R. LaBonte, Jeffrey T. Bagdanoff, Travis Stams, Patrick James Sarver
Publikováno v:
Journal of Medicinal Chemistry. 62:1793-1802
Protein tyrosine phosphatase SHP2 is an oncoprotein associated with cancer as well as a potential immune modulator because of its role in the programmed cell death PD-L1/PD-1 pathway. In the preceding manuscript, we described the optimization of a fu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a24d74ccebe527aac56b75855102ac3c
https://doi.org/10.1021/acs.jmedchem.8b01726
https://doi.org/10.1021/acs.jmedchem.8b01726
Autor:
Konstantin V Salojin, Brian D Hamman, Wei Chun Chang, Kanchan G Jhaver, Amin Al-Shami, Jeannette Crisostomo, Carrie Wilkins, Ann Marie Digeorge-Foushee, Jason Allen, Nita Patel, Suma Gopinathan, Julia Zhou, Amr Nouraldeen, Theodore C Jessop, Jeffrey T Bagdanoff, David J Augeri, Robert Read, Peter Vogel, Jonathan Swaffield, Alan Wilson, Kenneth A Platt, Kenneth G Carson, Alan Main, Brian P Zambrowicz, Tamas Oravecz
Publikováno v:
PLoS ONE, Vol 9, Iss 5, p e98151 (2014)
Mammalian sterile 20-like kinase 1 (Mst1) is a MAPK kinase kinase kinase which is involved in a wide range of cellular responses, including apoptosis, lymphocyte adhesion and trafficking. The contribution of Mst1 to Ag-specific immune responses and a
Externí odkaz:
https://doaj.org/article/1dff52e3692941429b8b20d7536589fd
Autor:
Christopher Towler, Andriana Jouk, Murphy Hentemann, Matthew J. LaMarche, Bing Yu, Jorge Garcia Fortanet, Michelle Fodor, Hongyun Wang, Sarah Williams, Morvarid Mohseni, Shumei Liu, Huaixiang Hao, Ritesh Bhanudasji Tichkule, Ying-Nan Chen, Chen Liu, Ping Wang, Patrick James Sarver, Stan Spence, Laura R. LaBonte, Jeffrey T. Bagdanoff, Brant Firestone, Michael Shultz, Martin Sendzik, Eric McNeill, Zhouliang Chen, Gang Liu, Victoriano Tamez, Robert Koenig, Michael G. Acker, Ho Man Chan, Travis Stams, Mitsunori Kato
Publikováno v:
Journal of medicinal chemistry. 62(7)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::385537f7a24ba5be8ef7298e05ce98f5
https://pubmed.ncbi.nlm.nih.gov/30688459
https://pubmed.ncbi.nlm.nih.gov/30688459
Autor:
Michael G. Acker, Ping Wang, Brant Firestone, Ying-Nan Chen, Shumei Liu, Jorge Garcia Fortanet, Michael Shultz, Robert Koenig, Ho Man Chan, Mitsunori Kato, Murphy Hentemann, Rukundo Ntaganda, Patrick James Sarver, Laura R. LaBonte, Martin Sendzik, Jeffrey T. Bagdanoff, Zhouliang Chen, Michelle Fodor, Movarid Mohseni, Travis Stams, Christopher Towler, Troy Smith, Stan Spence, Hongyun Wang, Matthew J. LaMarche, Michael Dore, Sarah Williams
Publikováno v:
Journal of medicinal chemistry. 62(7)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c41b30051a63a647dd7bbd399e7f584
https://pubmed.ncbi.nlm.nih.gov/30688462
https://pubmed.ncbi.nlm.nih.gov/30688462
Autor:
Movarid Mohseni, Michelle Fodor, Jorge Garcia Fortanet, Shumei Liu, Laura R. LaBonte, Rukundo Ntaganda, Jeffrey T. Bagdanoff, Sarah Williams, Robert Koenig, Travis Stams, Ho Man Chan, Michael Dore, Christopher Towler, Matthew J. LaMarche, Brant Firestone, Ping Wang, Troy Smith, Michael G. Acker, Murphy Hentemann, Ying-Nan Chen, Patrick James Sarver, Hongyun Wang, Stan Spence, Martin Sendzik, Mitsunori Kato, Zhouliang Chen
Publikováno v:
Journal of medicinal chemistry. 62(4)
SHP2 is a nonreceptor protein tyrosine phosphatase within the mitogen-activated protein kinase (MAPK) pathway controlling cell growth, differentiation, and oncogenic transformation. SHP2 also participates in the programed cell death pathway (PD-1/PD-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45eafbfd047a160231872f5fdd05d6ed
https://pubmed.ncbi.nlm.nih.gov/30900881
https://pubmed.ncbi.nlm.nih.gov/30900881
Autor:
Shejin Zhu, Xiaolei Ma, Rama Jain, Daniel Poon, Patrick Lee, Ann-Marie Madiera, Jeffrey T. Bagdanoff, Wooseok Han
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 25:3788-3792
A series of structure based drug design hypotheses and focused screening efforts led to the identification of tetrahydropyrrolo-diazepenones with striking potency against ERK2 kinase. The role of fluorination in mitigating microsomal clearance was sy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79018b575edb0d462b9e8e5ba2d56bcb
https://doi.org/10.1016/j.bmcl.2015.07.091
https://doi.org/10.1016/j.bmcl.2015.07.091
Publikováno v:
Journal of Medicinal Chemistry. 58:5781-5788
This analysis elucidates the impact of small molecule architecture on common in vitro ADME assays. In vitro parameters considered in this analysis included Caco-2 permeability/efflux, CYP3A4 inhibition, hERG inhibition, and rat microsomal extraction
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bbc0b91f89f58bcea0748ab59bf8db0b
https://doi.org/10.1021/acs.jmedchem.5b00552
https://doi.org/10.1021/acs.jmedchem.5b00552
Autor:
Alan Wilson, Iris B. Owusu, Boteju Lakmal W, Saadat Aleem, Philip Manton Brown, Jack Yan, Theodore C. Jessop, David J. Augeri, Suman Layek, Zhong Lai, S. David Kimball, Jill Hazelwood, William Heydorn, Kenneth G. Carson, Tamas Oravecz, Liam Moran, Suma Gopinathan, Haiming Zhang, Michael S. Donoviel, Amr Nouraldeen, William K. Sonnenburg, Jeffrey T. Bagdanoff, Jeffrey A. Kramer, Alan Main, Barbara Brooks, Li Dong, James E. Tarver, Padmaja Yalamanchili, Kenny Frazier, Marianne Carlsen, Mark S. Bednarz
Publikováno v:
Journal of Medicinal Chemistry. 53:8650-8662
Sphingosine 1-phosphate lyase (S1PL) has been characterized as a novel target for the treatment of autoimmune disorders using genetic and pharmacological methods. Medicinal chemistry efforts targeting S1PL by direct in vivo evaluation of synthetic an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c87e00a9781c267b0a4f8d1324759661
https://doi.org/10.1021/jm101183p
https://doi.org/10.1021/jm101183p
Autor:
Qingyun Liu, Weimei Sun, Amr Nouraldeen, Lawrence F. Courtney, Alan Wilson, Suman Layek, Marianne Carlsen, Sean Yu, Mark S. Bednarz, Zhong Lai, Ann Marie Digeorge-Foushee, Tamas Oravecz, Jerry A. Taylor, Traci Smith, Haiming Zhang, Liam Moran, Jonathan C. Swaffield, Debra Bruce, Jill Hazelwood, Simon D.P. Baugh, David J. Augeri, Emily O’Neill, Joseph Barbosa, Kristen M. Terranova, Suma Gopinathan, Gardyan Michael Walter, Huy Van Nguyen, S. David Kimball, Jeffrey T. Bagdanoff, Jack Yan, Theodore C. Jessop, Michael S. Donoviel, Qinghong Fu, Jeffrey A. Kramer, Alan Main, James E. Tarver, Kenneth G. Carson
Publikováno v:
Journal of Medicinal Chemistry. 52:3941-3953
During nearly a decade of research dedicated to the study of sphingosine signaling pathways, we identified sphingosine-1-phosphate lyase (S1PL) as a drug target for the treatment of autoimmune disorders. S1PL catalyzes the irreversible decomposition
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0adb6db472626b33c48fc85b6ff019d0
https://doi.org/10.1021/jm900278w
https://doi.org/10.1021/jm900278w