Zobrazeno 1 - 10
of 74
pro vyhledávání: '"Jeffrey T, Safrit"'
Autor:
Roger Tatoud, Christian Brander, Carey Hwang, Jo Kennelly, Shan Lu, Kevin O’Neil, Jeffrey T. Safrit, Iris Benhayoun, Julieta Firmat, Nelli Barriere
Publikováno v:
Emerging Microbes and Infections, Vol 13, Iss 1 (2024)
HIV vaccine development has been hindered by significant challenges over four decades. Despite persistent efforts, all efficacy trials to date have yielded disappointing results. This has pushed the field back to the discovery phase and created uncer
Externí odkaz:
https://doaj.org/article/1e868e7013ca4c5d9df6436e086114c7
Autor:
Adrian Rice, Mohit Verma, Annie Shin, Lise Zakin, Peter Sieling, Shiho Tanaka, Joseph Balint, Kyle Dinkins, Helty Adisetiyo, Brett Morimoto, Wendy Higashide, C. Anders Olson, Shivani Mody, Patricia Spilman, Elizabeth Gabitzsch, Jeffrey T. Safrit, Shahrooz Rabizadeh, Kayvan Niazi, Patrick Soon-Shiong
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-15 (2021)
Abstract We have developed a COVID-19 vaccine, hAd5 S-Fusion + N-ETSD, that expresses SARS-CoV-2 spike (S) and nucleocapsid (N) proteins with modifications to increase immune responses delivered using a human adenovirus serotype 5 (hAd5) platform. He
Externí odkaz:
https://doaj.org/article/c2a806620483477893a8b28004af78a6
Autor:
Adrian Rice, Mohit Verma, Emily Voigt, Peter Battisti, Sam Beaver, Sierra Reed, Kyle Dinkins, Shivani Mody, Lise Zakin, Shiho Tanaka, Brett Morimoto, C. Anders Olson, Elizabeth Gabitzsch, Jeffrey T. Safrit, Patricia Spilman, Corey Casper, Patrick Soon-Shiong
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
We assessed if immune responses are enhanced in CD-1 mice by heterologous vaccination with two different nucleic acid-based COVID-19 vaccines: a next-generation human adenovirus serotype 5 (hAd5)-vectored dual-antigen spike (S) and nucleocapsid (N) v
Externí odkaz:
https://doaj.org/article/dc6ab025ea6648e8bf50a56a033d58df
Autor:
Elizabeth Gabitzsch, Jeffrey T. Safrit, Mohit Verma, Adrian Rice, Peter Sieling, Lise Zakin, Annie Shin, Brett Morimoto, Helty Adisetiyo, Raymond Wong, Ashish Bezawada, Kyle Dinkins, Joseph Balint, Victor Peykov, Hermes Garban, Philip Liu, Andrew Bacon, Pete Bone, Jeff Drew, Daniel C. Sanford, Patricia Spilman, Lennie Sender, Shahrooz Rabizadeh, Kayvan Niazi, Patrick Soon-Shiong
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
We have developed a dual-antigen COVID-19 vaccine incorporating genes for a modified SARS-CoV-2 spike protein (S-Fusion) and the viral nucleocapsid (N) protein with an Enhanced T-cell Stimulation Domain (N-ETSD) to increase the potential for MHC clas
Externí odkaz:
https://doaj.org/article/eaca2f9f97bc467580412ac134a60533
Autor:
Patrick Soon-Shiong, Dean A. Lee, Yaya Chu, Gaurav Nayyar, Jeffrey T Safrit, Susiyan Jiang, Jeremy M. Rosenblum, Mitchell S. Cairo
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 9, Iss 7 (2021)
Background Children with recurrent and/or metastatic osteosarcoma (OS), neuroblastoma (NB) and glioblastoma multiforme (GBM) have a dismal event-free survival (
Externí odkaz:
https://doaj.org/article/88879cd3923d4e4d9638289ac32ef8a0
Autor:
John Lee, Dean Lee, Patrick Soon-Shiong, Yaya Chu, Gaurav Nayyar, Nang Kham Su, Jeremy M Rosenblum, Jeffrey T Safrit, Matthew Barth, Mitchell S Cairo
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 8, Iss 2 (2020)
Background The prognosis of patients with relapsed or progressive B cell (CD20+) non-Hodgkin’s lymphoma (B-NHL), including Burkitt lymphoma (BL), is dismal due to chemoradiotherapy resistance. Novel therapeutic strategies are urgently needed. N-820
Externí odkaz:
https://doaj.org/article/752d96bf91744f83a32d2522239e2b10
Autor:
Gabriela M Webb, Jhomary Molden, Kathleen Busman-Sahay, Shaheed Abdulhaqq, Helen L Wu, Whitney C Weber, Katherine B Bateman, Jason S Reed, Mina Northrup, Nicholas Maier, Shiho Tanaka, Lina Gao, Brianna Davey, Benjamin L Carpenter, Michael K Axthelm, Jeffrey J Stanton, Jeremy Smedley, Justin M Greene, Jeffrey T Safrit, Jacob D Estes, Pamela J Skinner, Jonah B Sacha
Publikováno v:
PLoS Pathogens, Vol 16, Iss 3, p e1008339 (2020)
Despite the success of antiretroviral therapy (ART) to halt viral replication and slow disease progression, this treatment is not curative and there remains an urgent need to develop approaches to clear the latent HIV reservoir. The human IL-15 super
Externí odkaz:
https://doaj.org/article/01a8e5f9eca0493ca269580027d9bf0e
Autor:
Amy L, Ellis-Connell, Alexis J, Balgeman, Nadean M, Kannal, Karigynn, Hansen Chaimson, Anna, Batchenkova, Jeffrey T, Safrit, Shelby L, O'Connor
Publikováno v:
Infect Immun
Mucosal associated invariant T (MAIT) cells are innate T cells that recognize bacterial metabolites and secrete cytokines and cytolytic enzymes to destroy infected target cells. This makes MAIT cells promising targets for immunotherapy to combat bact
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::05341d0c46eed4ee03b0776b4300fb27
https://pubmed.ncbi.nlm.nih.gov/36190256
https://pubmed.ncbi.nlm.nih.gov/36190256
Autor:
Amy L. Ellis-Connell, Alexis J. Balgeman, Olivia E. Harwood, Ryan V. Moriarty, Jeffrey T. Safrit, Andrea M. Weiler, Thomas C. Friedrich, Shelby L. O’Connor
Publikováno v:
J Virol
The IL-15 superagonist N-803 has been shown to enhance the function of CD8 T cells and NK cells. We previously found that in a subset of vaccinated, ART-naive, SIV(+) rhesus macaques, N-803 treatment led to a rapid but transient decline in plasma vir
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3eafcef296021a0a78bc6d62e5fde18
https://pubmed.ncbi.nlm.nih.gov/36190241
https://pubmed.ncbi.nlm.nih.gov/36190241
Autor:
Jeffrey S. Miller, Zachary B. Davis, Erika Helgeson, Cavan Reilly, Ann Thorkelson, Jodi Anderson, Noemia S. Lima, Siri Jorstad, Geoffrey T. Hart, John H. Lee, Jeffrey T. Safrit, Hing Wong, Sarah Cooley, Lavina Gharu, Hyunsoo Chung, Patrick Soon-Shiong, Curtis Dobrowolski, Courtney V. Fletcher, Jonathan Karn, Daniel C. Douek, Timothy W. Schacker
Publikováno v:
Nature Medicine. 28:392-400
There is no cure for HIV infection, and lifelong antiretroviral therapy (ART) is required. N-803 is an IL-15 superagonist comprised of an N72D mutant IL-15 molecule attached to its alpha receptor and a human IgG1 fragment designed to increase IL-15 a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e25f9b3671f9c6c78a6829d80a5a5220
https://doi.org/10.1038/s41591-021-01651-9
https://doi.org/10.1038/s41591-021-01651-9