Zobrazeno 1 - 9 of 9 pro vyhledávání: '"Jeffrey Schoellerman"'
1
Akademický článek
Molecular determinants of ASIC1 modulation by divalent cations
Autor: Yi Liu, Jichun Ma, Renee L. DesJarlais, Rebecca Hagan, Jason Rech, Changlu Liu, Robyn Miller, Jeffrey Schoellerman, Jinquan Luo, Michael Letavic, Bruce Grasberger, Michael P. Maher
Publikováno v: Scientific Reports, Vol 14, Iss 1, Pp 1-7 (2024)
Abstract Acid-sensing ion channels (ASICs) are proton-gated cation channels widely expressed in the nervous system. ASIC gating is modulated by divalent cations as well as small molecules; however, the molecular determinants of gating modulation by d
Externí odkaz: https://doaj.org/article/7532453b22314d01ada9b275f434a0b8
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2
Akademický článek
Molecular mechanism and structural basis of small-molecule modulation of the gating of acid-sensing ion channel 1
Autor: Yi Liu, Jichun Ma, Renee L. DesJarlais, Rebecca Hagan, Jason Rech, David Lin, Changlu Liu, Robyn Miller, Jeffrey Schoellerman, Jinquan Luo, Michael Letavic, Bruce Grasberger, Michael Maher
Publikováno v: Communications Biology, Vol 4, Iss 1, Pp 1-15 (2021)
Liu et al study the molecular and structural mechanism of the modulation of ASIC1 channel gating using functional, crystallographic, computational and mutational approaches. They identify small molecules that allosterically stabilize the closed state
Externí odkaz: https://doaj.org/article/cd6928ca293c4d9a8cd20517994d727a
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3
Akademický článek
Dual actions of Psalmotoxin at ASIC1a and ASIC2a heteromeric channels (ASIC1a/2a)
Autor: Yi Liu, Rebecca Hagan, Jeffrey Schoellerman
Publikováno v: Scientific Reports, Vol 8, Iss 1, Pp 1-11 (2018)
Abstract Acid-Sensing Ion Channels (ASICs) are gated by extracellular protons and play important roles in physiological and pathological states, such as pain and stroke. ASIC1a and ASIC2a, two of the most highly expressed subunits in the brain, form
Externí odkaz: https://doaj.org/article/6ecfee660a634987bfb6e194583a7b0a
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5
Molecular mechanism and structural basis of small-molecule modulation of the gating of acid-sensing ion channel 1
Autor: Jason C. Rech, Bruce L. Grasberger, Michael A. Letavic, Jinquan Luo, Changlu Liu, Jichun Ma, Michael P. Maher, Renee L. DesJarlais, Jeffrey Schoellerman, Rebecca Hagan, Yi Liu, Robyn L. Miller, David Lin
Publikováno v: Communications Biology, Vol 4, Iss 1, Pp 1-15 (2021)
Communications Biology
Acid-sensing ion channels (ASICs) are proton-gated cation channels critical for neuronal functions. Studies of ASIC1, a major ASIC isoform and proton sensor, have identified acidic pocket, an extracellular region enriched in acidic residues, as a key
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1fcb9a64556aa30386ccae13fe0c1e06
https://doaj.org/article/cd6928ca293c4d9a8cd20517994d727a
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9
SYNCHRONOUS AND ASYNCHRONOUS TRANSMITTER RELEASE AT NICOTINIC SYNAPSES ARE DIFFERENTIALLY REGULATED BY POSTSYNAPTIC PSD-95 PROTEINS
Autor: William G. Conroy, Darwin K. Berg, Jeffrey Schoellerman, Robert A. Neff
The rate and timing of information transfer at neuronal synapses are critical for determining synaptic efficacy and higher network function. Both synchronous and asynchronous neurotransmitter release shape the pattern of synaptic influences on a neur
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0fe09069aba4add52379b5e7147434ae
https://europepmc.org/articles/PMC2844112/
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