Zobrazeno 1 - 10
of 50
pro vyhledávání: '"Jeffrey S. Wiseman"'
Publikováno v:
Toxicology in vitro : an international journal published in association with BIBRA. 67
Oligomycin is a classical mitochondrial reagent that binds to the proton channel on the Fo component of ATP synthase. As a result, oligomycin blocks mitochondrial ATP synthesis, proton translocation, and O2 uptake. Here we show that oligomycin induce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f89cb2ec31d5adff220fcf77312ed066
https://pubmed.ncbi.nlm.nih.gov/32502624
https://pubmed.ncbi.nlm.nih.gov/32502624
Autor:
Jeffrey S. Wiseman, Nathan C. Law, Cara Schildmeyer, Craig S. Nunemaker, Kathryn L. Corbin, Christopher D. Waters, Avery M Bogart, Hannah L. West, Nicholas W. Vann, Nicholas B. Whitticar, Ishrat Jahan
Publikováno v:
Endocrinology. 159:3747-3760
An early sign of islet failure in type 2 diabetes (T2D) is the loss of normal patterns of pulsatile insulin release. Disruptions in pulsatility are associated with a left shift in glucose sensing that can cause excessive insulin release in low glucos
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12a47565279c572d29ee0ee8ff060be7
https://doi.org/10.1210/en.2018-00589
https://doi.org/10.1210/en.2018-00589
Autor:
Haotong Chen, Yuehan Yang, Cuilin Cheng, Zhenyu Li, Jeffrey S. Wiseman, Yong Han, Lingying Tong, Shiyong Wu
Publikováno v:
Toxicol Appl Pharmacol
Mathermycin, a lantipeptide isolated from marine actinomycete Marinactinospora thermotolerans, is an antibiotic that has been shown to disrupt bacterial plasma membrane. We now provide evidences that mathermycin can also disrupt cancer, but not norma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d63b1b1d423ef17e2dd9dcfae15bba3
https://doi.org/10.1016/j.taap.2021.115410
https://doi.org/10.1016/j.taap.2021.115410
Autor:
David Bower, Jeffrey S. Wiseman, Michael Schwarz, Brigitte Landesmann, Martin O. Leonard, Marina Goumenou, Silvia Maggioni, Paul Jennings
Publikováno v:
Archives of Toxicology. 88:2099-2133
There is an urgent need for the development of alternative methods to replace animal testing for the prediction of repeat dose chemical toxicity. To address this need, the European Commission and Cosmetics Europe have jointly funded a research progra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f53d18cda20f60b18f589f0fa2ac649e
https://doi.org/10.1007/s00204-014-1410-8
https://doi.org/10.1007/s00204-014-1410-8
Publikováno v:
Journal of Biological Chemistry. 289:3529-3538
Cytochrome P450 46A1 (CYP46A1) is a brain-specific cholesterol 24-hydroxylase responsible for the majority of cholesterol elimination from the brain. Genetically increased CYP46A1 expression in mice leads to improved cognition and decreases manifesta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::951aa6db0406ece30cd53cde1d97dcf3
https://doi.org/10.1074/jbc.m113.532846
https://doi.org/10.1074/jbc.m113.532846
Publikováno v:
Journal of Herbal Medicine. :100282
The authors describe the effects of an ethanol extract of maca root on glucose uptake and metabolism in cultured 3T3-L1 adipocytes. The extract stimulates glucose uptake and shares many features of an insulin mimetic: increased phosphorylation of ins
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a4b71fb05038c0a5860ab1ad7202e934
https://doi.org/10.1016/j.hermed.2019.100282
https://doi.org/10.1016/j.hermed.2019.100282
Autor:
Natalia Mast, Irina A. Pikuleva, Jeffrey S. Wiseman, Matthew Clark, C. David Stout, Marlin Linger
Publikováno v:
Molecular Pharmacology. 82:824-834
Cytochrome P450 46A1 (cholesterol 24-hydroxylase) is an important brain enzyme that may be inhibited by structurally distinct pharmaceutical agents both in vitro and in vivo. To identify additional inhibitors of CYP46A1 among U.S. Food and Drug Admin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7438f463769f39f6248007042309e54
https://doi.org/10.1124/mol.112.080424
https://doi.org/10.1124/mol.112.080424
Publikováno v:
Journal of Chemical Information and Modeling. 51:52-60
We introduce TICRA (transplant-insert-constrain-relax-assemble), a method for modeling the structure of unknown protein-ligand complexes using the X-ray crystal structures of homologous proteins and ligands with known activity. We present results fro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b904e9fe3582307a8728d8cca8b1d49c
https://doi.org/10.1021/ci100256u
https://doi.org/10.1021/ci100256u
Autor:
Steven J. Freedman, Matthew Clark, Jinming Zou, Jeffrey S. Wiseman, Jennifer L. Ludington, George Talbot, Sia Meshkat, Zenon Konteatis
Publikováno v:
Drug Development Research. 70:279-287
The development of small-molecule drugs to counter the threat of bioterrorism will differ from classical drug discovery because it will be impossible to evaluate efficacy in clinical trials for many agents. This difference focuses biodefense on the i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::78c08cdc8f5a8ea3d7b680d427268f69
https://doi.org/10.1002/ddr.20305
https://doi.org/10.1002/ddr.20305
Publikováno v:
Journal of Chemical Information and Modeling. 49:934-943
The principles behind the computation of protein-ligand binding free energies by Monte Carlo simulation in the Grand Canonical Ensemble are described in detail, and two variations of the calculation are presented. The computation can be performed by
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::955d4b639d07b2bbcf7bb0e16bf2780b
https://doi.org/10.1021/ci8004397
https://doi.org/10.1021/ci8004397