Absences of Endothelial Microvesicle Changes in the Presence of the Endotheliopathy of Trauma

Autor: Jakob Stensballe, Sisse R. Ostrowski, Erika Gonzalez Rodriguez, Yao-Wei W. Wang, Bryan A. Cotton, Lisa A. Baer, Pär I. Johansson, Hanne H. Henriksen, Jessica C. Cardenas, Jeffrey S. Tomasek, Nena Matijevic, Tzu-An Chen, Charles E. Wade, Ernesto Lopez, John B. Holcomb

Publikováno v: Shock. 51:180-184

Introduction Severe trauma is accompanied by endothelial glycocalyx disruption, which drives coagulopathy, increasing transfusion requirements and death. This syndrome has been termed endotheliopathy of trauma (EOT). Some have suggested EOT results f

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13e3eb254ad63a236b37849221501dcd
https://doi.org/10.1097/shk.0000000000001149

Syndecan-1: A Quantitative Marker for the Endotheliopathy of Trauma

Autor: Pär I. Johansson, Jakob Stensballe, John B. Holcomb, Charles E. Wade, Sisse R. Ostrowski, Jeffrey S. Tomasek, Hanne H. Henriksen, Erika Gonzalez Rodriguez, Jessica C. Cardenas, Bryan A. Cotton, Lisa A. Baer

Publikováno v: Gonzalez Rodriguez, E, Ostrowski, S R, Cardenas, J C, Baer, L A, Tomasek, J S, Henriksen, H H, Stensballe, J, Cotton, B A, Holcomb, J B, Johansson, P I & Wade, C E 2017, ' Syndecan-1 : A Quantitative Marker for the Endotheliopathy of Trauma ', Journal of the American College of Surgeons, vol. 225, no. 3, pp. 419-427 . https://doi.org/10.1016/j.jamcollsurg.2017.05.012

Background Endothelial glycocalyx breakdown elicits syndecan-1 shedding and endotheliopathy of trauma (EoT). We hypothesized that a cutoff syndecan-1 level can identify patients with endothelial dysfunction who would have poorer outcomes. Study Desig

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b5bdb65a474688da09ddc7faca79c6f
https://doi.org/10.1016/j.jamcollsurg.2017.05.012

Multicenter observational prehospital resuscitation on helicopter study

Autor: Deborah M. Stein, Stacia M. DeSantis, Mi-Sung Yi, Savitri N. Appana, Jeanette M. Podbielski, Jeffrey D. Kerby, Terence O'Keeffe, Kenji Inaba, Martin A. Schreiber, Bulger Em, Greene Tj, Zielinski, Jeffrey S. Tomasek, John B. Holcomb, Michael D. Goodman, Swartz, Charles E. Wade, Fox Ee

Publikováno v: Journal of Trauma and Acute Care Surgery. 83:S83-S91

Earlier use of in-hospital plasma, platelets, and red blood cells (RBCs) has improved survival in trauma patients with severe hemorrhage. Retrospective studies have associated improved early survival with prehospital blood product transfusion (PHT).

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8550df2c3567f6608c9a2cc57e20c6d
https://doi.org/10.1097/ta.0000000000001484

Trends in 1029 trauma deaths at a level 1 trauma center: Impact of a bleeding control bundle of care

Autor: Blessing T. Oyeniyi, Michelle Scerbo, Jeffrey S. Tomasek, John B. Holcomb, Erin E. Fox, Charles E. Wade

Publikováno v: Injury. 48:5-12

Over the last decade the age of trauma patients and injury mortality has increased. At the same time, many centers have implemented multiple interventions focused on improved hemorrhage control, effectively resulting in a bleeding control bundle of c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba5dddef52b963bcb514cfa32e5f7d52
https://doi.org/10.1016/j.injury.2016.10.037

Trends in potentially preventable trauma deaths between 2005-2006 and 2012-2013

Autor: Michelle Scerbo, Blessing T. Oyeniyi, Erin E. Fox, Charles E. Wade, John B. Holcomb, Jeffrey S. Tomasek, Ezra Y. Koh

Publikováno v: American journal of surgery. 218(3)

Most studies of trauma deaths include non-preventable deaths, potentially limiting successful intervention efforts. In this study we aimed to compare the potentially preventable trauma deaths between 2 time periods at our institution.Trauma patients

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a39fcf25ebf0c4735f9b403ac5f198d
https://pubmed.ncbi.nlm.nih.gov/30595330