Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Jeffrey S. Tan"'
Publikováno v:
Burger's Medicinal Chemistry and Drug Discovery
Autor:
David T. White, Naijia Huang, Jeffrey S. Tan, Kenneth J. Ruterbories, Jason Liu, Derek Brocksmith, Lee J. Burns, Alain Stricker-Krongrad, Nathan Yumibe, Nita J. Patel, Guy Bouchard
Publikováno v:
International Journal of Pharmacokinetics. 2:81-91
Aim: Oral and intravenous pharmacokinetic (PK) studies were conducted in four different minipig strains: Sinclair, Yucatan, Hanford and Göttingen after administration of metformin or R,S-verapamil (R,S-VER). Results: The results indicated that the P
Publikováno v:
Journal of Chemical Theory and Computation. 12:5157-5169
Metadynamics is an important enhanced sampling technique in molecular dynamics simulation to efficiently explore potential energy surfaces. The recently developed transition-tempered metadynamics (TTMetaD) has been proven to converge asymptotically w
Publikováno v:
Journal of pharmaceutical sciences. 108(8)
In an effort to reduce development time and costs associated with active pharmaceutical ingredient process solvent selection and crystallization design, a tiered approach to crystallization solvent selection was developed that leverages different sol
Publikováno v:
Translating Molecules into Medicines ISBN: 9783319500409
The role of the developability (aka preformulation) scientist at the discovery development interface has been extensively discussed in the literature. In response to shifting trends in discovery and the continued push to shorten timelines and reduce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::36dd9ad80cb9573af22b4b5e714b362d
https://doi.org/10.1007/978-3-319-50042-3_7
https://doi.org/10.1007/978-3-319-50042-3_7
Autor:
Jose Francisco M. Atienza, Joanner Paulus Erik P. Alaba, Jerick Jeffrey S. Tan, Jay Edneil C. Olivar, Grecebio Jonathan D. Alejandro, IV Maximo T. Umali
The majority of the population in the Philippines relies on herbal products as their primary source for their healthcare needs. After the recognition of Vitex negundo L. (lagundi) as an important and effective alternative medicine for cough, sore thr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b92eb48982c2bd140f5099f370382c5
Publikováno v:
Journal of Pharmaceutical Sciences. 100:4756-4765
Dogs are one of the most commonly used non-rodent species in toxicology studies and are known to have basal stomach pH ranging from 2 to 7 in the fasted state. Thus absorption and resulting plasma exposure of weakly basic compounds administered as cr
Publikováno v:
The Journal of Chemical Physics. 149:072310
Estimating the permeability coefficient of small molecules through lipid bilayer membranes plays an important role in the development of effective drug candidates. In silico simulations can produce acceptable relative permeability coefficients for a
Autor:
Jon Hilden, Kenneth R. Morris, Joseph G. Stowell, Jeffrey S. Tan, Caesar E. Reyes, Matthew J. Kelm
Publikováno v:
Crystal Growth & Design. 3:921-926
Crystallization of pharmaceutically active compounds from saturated solutions by means of solvent evaporation typically involves a nucleation and growth process. At slow solvent evaporation rates, ...
Publikováno v:
Journal of computational chemistry. 33(9)
The present work details the development of a core-shell model for the purposes of obtaining potential-derived point charges from the ab initio molecular electrostatic potential. In contrast to atomic point charge models, the core-shell model decompo