Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Jeffrey S. Swers"'
Autor:
David A. Tice, Jeffrey S. Swers, Justin P. Edwards, Sinnie Ng, David M. Hilbert, Haiyan Wang, David W. Lafleur, Samantha McCullough, Janine M Buonato, Liubov Zaritskaya, Ankit Gupta, Jenny Mu
Publikováno v:
Cancer Research. 81:1549-1549
Genetically engineered T cells have demonstrated great promise in the treatment of hematologic malignancies including Acute Lymphocytic Leukemia, Non-Hodgkin's lymphoma, and Multiple Myeloma. However, those achievements are often associated with unco
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::713cc4839e297f93bb76b7014923b9d7
https://doi.org/10.1158/1538-7445.am2021-1549
https://doi.org/10.1158/1538-7445.am2021-1549
Autor:
Rosa A. Carrasco, Luba Grinberg, Lin Wang, Ching Ching Leow, Zhan Xiao, Kristen Lekstrom, Ivan Inigo, Herren Wu, Manuel Baca, Hui Feng, Jeffrey S. Swers, David A. Tice
Publikováno v:
Molecular Cancer Therapeutics. 12:1235-1244
Activation of TNF-related apoptosis-inducing ligand receptor 2 (TRAILR2) can induce apoptosis in a variety of human cancer cell lines and xenografts, while lacking toxicity in normal cells. The natural ligand and agonistic antibodies show antitumor a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e35f43c44797641467d3f223f167b3b
https://doi.org/10.1158/1535-7163.mct-12-1107
https://doi.org/10.1158/1535-7163.mct-12-1107
Publikováno v:
Biochemical and Biophysical Research Communications. 350:508-513
We have characterized the IgG form of a previously isolated and engineered single-chain Fv (scFv), named RR2r3s4-1, that binds to human PSGL-1. This fully human IgG was determined to have a Kd of 1.8+/-0.7 nM by fluorescence quenching titration. It b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2a88bca80fd7efce4ccf0de2f304838
https://doi.org/10.1016/j.bbrc.2006.08.197
https://doi.org/10.1016/j.bbrc.2006.08.197
Publikováno v:
Biotechnology Progress. 19:1033-1037
Selectins are cell adhesion molecules that mediate capture of leukocytes on vascular endothelium as an essential component of the inflammatory response. Here we describe a method for yeast surface display of selectins, together with a functional assa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e9b4ba91c13d94f3447856e30d29844
https://doi.org/10.1021/bp025756b
https://doi.org/10.1021/bp025756b
Autor:
Robert W. Siegel, Yik Andy Yeung, Peter Heinzelman, James R. Coleman, Christilyn P Graff, Lee K. Opresko, H. Steven Wiley, Jennifer R. Cochran, K. Dane Wittrup, David W. Colby, Michael J. Feldhaus, Jeffrey S. Swers, Jane M. Weaver Feldhaus
Publikováno v:
Nature Biotechnology. 21:163-170
A nonimmune library of 10(9) human antibody scFv fragments has been cloned and expressed on the surface of yeast, and nanomolar-affinity scFvs routinely obtained by magnetic bead screening and flow-cytometric sorting. The yeast library can be amplifi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb8d834cab315446b8045484a6c1711f
https://doi.org/10.1038/nbt785
https://doi.org/10.1038/nbt785
Publikováno v:
Protein engineering, designselection : PEDS. 27(10)
Non-antibody scaffolds are increasingly used to generate novel binding proteins for both research and therapeutic applications. Our group has developed the tenth fibronectin type III domain of human tenascin-C (TNfn3) as one such scaffold. As a scaff
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0a87ccc4d3c8cf285e28a1f85d6ac39
https://pubmed.ncbi.nlm.nih.gov/24996411
https://pubmed.ncbi.nlm.nih.gov/24996411
Publikováno v:
Biotechnology and Bioengineering. 64:250-254
Organophosphorus hydrolase (OPH) has been incorporated within polyurethane foams during polymer synthesis as a means of reducing the enzyme's environmental sensitivity to alterations in pH and bleach-induced enzyme denaturation. Unfavorable losses of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::74ea5a3eeacc29bd17165c50448cae80
https://doi.org/10.1002/(sici)1097-0290(19990720)64:2<250::aid-bit14>3.0.co
https://doi.org/10.1002/(sici)1097-0290(19990720)64:2<250::aid-bit14>3.0.co
Publikováno v:
PMC
Antibody affinity maturation proceeds in vivo via a combination of point mutations, insertions, deletions, and combinatorial shuffling of light chains or portions of the heavy chain, thereby reducing the probability of trapping in local affinity opti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad317e17cf4dc32bcf37b38e77cdba33
https://pubmed.ncbi.nlm.nih.gov/20645027
https://pubmed.ncbi.nlm.nih.gov/20645027
Autor:
David W, Colby, Brenda A, Kellogg, Christilyn P, Graff, Yik A, Yeung, Jeffrey S, Swers, K Dane, Wittrup
Publikováno v:
Methods in enzymology. 388
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b3a175f25a2cd1e30fd43270bf6ca236
https://pubmed.ncbi.nlm.nih.gov/15289082
https://pubmed.ncbi.nlm.nih.gov/15289082
Publikováno v:
Nucleic acids research. 32(3)
Homologous recombination in yeast can be exploited to reliably generate libraries of10(7) transformants from a pool of PCR products and a linearized plasmid vector. Homology in the PCR insertion products drives shuffling of these genes in vivo by yea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62cfca043b52d9ffc156ff6784e6513f
https://pubmed.ncbi.nlm.nih.gov/14978223
https://pubmed.ncbi.nlm.nih.gov/14978223