Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Jeffrey S. Sprouse"'
Autor:
Sarah J. Jefferson, Ian Gregg, Mark Dibbs, Clara Liao, Hao Wu, Pasha A. Davoudian, Samuel C. Woodburn, Patrick H. Wehrle, Jeffrey S. Sprouse, Alexander M. Sherwood, Alfred P. Kaye, Christopher Pittenger, Alex C. Kwan
Publikováno v:
Neuropsychopharmacology.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e463ccff55f744ab6c81b1a1982ef68e
https://doi.org/10.1038/s41386-023-01572-w
https://doi.org/10.1038/s41386-023-01572-w
Autor:
Sarah J. Jefferson, Ian Gregg, Mark Dibbs, Clara Liao, Hao Wu, Pasha A. Davoudian, Jeffrey S. Sprouse, Alexander M. Sherwood, Alfred P. Kaye, Christopher Pittenger, Alex C. Kwan
Serotonergic psychedelics are gaining increasing interest as potential therapeutics for a range of mental illnesses. Compounds with short-lived subjective effects may be clinically useful because dosing time would be reduced, which may improve patien
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5e5a5ec2b0e54fcc34b1df2125a7c46c
https://doi.org/10.1101/2022.11.03.515044
https://doi.org/10.1101/2022.11.03.515044
Publikováno v:
Journal of Medicinal Chemistry, 46(25), 5365-5374. AMER CHEMICAL SOC
On the basis of a set of 20 diverse 5-HT7 receptor agonists, the pharmacophore for 5-HT7 receptor agonism was determined. Additionally two CoMFA models were developed, based on different alignments of the agonists. Both models show good correlations
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f7df6cdb0ed8d51c6f81797ed644a42
https://doi.org/10.1021/jm030826m
https://doi.org/10.1021/jm030826m
Publikováno v:
Biochemical Pharmacology. 48:1501-1508
The impact of tryptophan (TRP) pretreatment on the neurochemical effects of p-chloroamphetamine (PCA) was investigated. The neurotoxic effects of PCA on serotonin (5-HT) neurons, the acute effects of PCA on extracellular 5-HT and dopamine (DA), and t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::862669fabe14413e9cbc1d3675e48121
https://doi.org/10.1016/0006-2952(94)90576-2
https://doi.org/10.1016/0006-2952(94)90576-2
Publikováno v:
Brain Research. 617:159-162
The binding of [3H]8-OH-DPAT and [3H]paroxetine to 5-HT1A and 5-HT uptake sites (respectively) was examined in membranes prepared from bovine dorsal raphe and hippocampus. KD and Bmax values for [3H]8-OH-DPAT binding were indistinguishable in dorsal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67c6a1920d2575f41a347c28fe9b3b3a
https://doi.org/10.1016/0006-8993(93)90629-2
https://doi.org/10.1016/0006-8993(93)90629-2
Publikováno v:
Annals of the New York Academy of Sciences. 600:93-103
It is becoming evident that the diverse electrophysiological actions of 5-HT in the central nervous system can be best formulated in terms of receptor subtypes and their respective effector mechanisms. Based on the findings described in this review,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e4ef6577a099547861f304ca583ad8b
https://doi.org/10.1111/j.1749-6632.1990.tb16875.x
https://doi.org/10.1111/j.1749-6632.1990.tb16875.x
Autor:
Cor J. Grol, Marjan van Smeden, Anne W Schmidt, Håkan Wikström, Erik S Vermeulen, Jeffrey S Sprouse
Publikováno v:
Journal of Medicinal Chemistry, 47(22), 5451-5466. AMER CHEMICAL SOC
A series of arylpiperazine- and 1,2,3,4-tetrahydroisoquinoline-based arylsulfonamides was synthesized and evaluated for their interactions with the constitutively active 5-HT7 receptor. Effects on basal adenylate cyclase activity were measured using
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::088603e4b6f2d325facd4f1efb3520cf
https://research.rug.nl/en/publications/52e60827-0c93-48b0-87c6-ea76b0b8054e
https://research.rug.nl/en/publications/52e60827-0c93-48b0-87c6-ea76b0b8054e
Autor:
Jeffrey S. Sprouse
Publikováno v:
European journal of pharmacology. 201(2-3)
The effect of a novel ligand for the 5-HT1A receptor subtype, MDL 73005EF, on the firing rate of serotonergic dorsal raphe neurons was assessed in rat midbrain slices maintained in vitro. Superfusion with MDL 73005EF inhibited neuronal firing in a co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e5d21106e0bac7e23813232d8313c64
https://pubmed.ncbi.nlm.nih.gov/1839146
https://pubmed.ncbi.nlm.nih.gov/1839146
Publikováno v:
Advances in Experimental Medicine and Biology ISBN: 9781468459548
The technique of microdialysis offers a unique avenue for monitoring extracellular chemical dynamics in nervous tissue. In using this technique to monitor neurotransmitters with high affinity uptake systems, the accurate determination of the extremel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::50da5f79225f743755864c12fe09c83c
https://doi.org/10.1007/978-1-4684-5952-4_7
https://doi.org/10.1007/978-1-4684-5952-4_7
Autor:
Priscilla W. Sheldon, Robert H. Roth, Jeffrey S. Sprouse, Charles W. Bradberry, George K. Aghajanian
Publikováno v:
Journal of neuroscience methods. 36(1)
A novel microdialysis technique suitable for parallel measurements of neurotransmitter release and single unit recordings from brain slices is presented. The effects of 3,4-methylenedioxymethamphetamine (MDMA) on slices of dorsal raphe nucleus and fr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::013cc32fc41378d5600c7e909569018d
https://pubmed.ncbi.nlm.nih.gov/1676433
https://pubmed.ncbi.nlm.nih.gov/1676433