Zobrazeno 1 - 10
of 60
pro vyhledávání: '"Jeffrey S. Nye"'
Autor:
Fumio Nakamura, Husseini K. Manji, Namrata D. Udeshi, Hagop S. Akiskal, Jeffrey H. Price, Nikolaos Venizelos, Wen-Ning Zhao, Cordulla Duerr, Ryan W. Logan, Jeffrey S. Nye, Jasmin Lalonde, Steven D. Sheridan, Joseph T. Coyle, Toshio Ohshima, Yoshio Goshima, Michael McCarthy, Shelley Halpain, Barbara Calabrese, Joshua G. Hunsberger, Martin Alda, Yuuka Inoue, Gustavo J. Gutierrez, Stephen J. Haggarty, Brian T. D. Tobe, Cameron D. Pernia, Richard L. Sidman, Moyuka Wada, Hiroko Makihara, Laurence M. Brill, Glenn T. Konopaske, Yang Liu, De-Maw M. Chuang, Ranor C. B. Basa, Alicia M. Winquist, Yang D. Teng, Michelle M. Sidor, Steven A. Carr, Colleen A. McClung, Guy A. Rouleau, Katsuhiko Mikoshiba, Evan Y. Snyder, Laurel Dorsett, Lina Mastrangelo, Guang Chen, Jianxue Li, Haruko Nakamura, Andrew Crain, Philipp Mertins, Michael G. Brandel, Dongmei Wu, Naoya Yamashita
Publikováno v:
Publikationer från Örebro universitet.
The molecular pathogenesis of bipolar disorder (BPD) is poorly understood. Using human-induced pluripotent stem cells (hiPSCs) to unravel such mechanisms in polygenic diseases is generally challenging. However, hiPSCs from BPD patients responsive to
Autor:
Alan Baseman, John Han, Mary Sano, Jeffrey S. Nye, H. Robert Brashear, Klaus Hager, Henry M Richards, Bonnie Davis
Publikováno v:
Alzheimer's Research & Therapy
Background A large, prospective, 2-year, randomized study in patients with mild-to-moderate Alzheimer’s disease or mixed dementia demonstrated reductions in mortality and cognitive/functional decline in galantamine-treated patients. A post-hoc anal
Publikováno v:
Current Opinion in Pharmacology. 11:521-527
Identifying the molecular and cellular basis of complex neuropsychiatric disorders (cNPDs) has been limited by the inaccessibility of central neurons, variability within broad diagnostic classifications, and the interplay of genetic and environmental
Autor:
Jeffrey S. Nye, Surya Mohanty, Partha Nandy, Stefan Ochalski, Eugene Cox, Mariëlle Eerdekens, Ihab G. Girgis, Steven Wang, Lisa Ford
Publikováno v:
Epilepsia. 51:1954-1962
Summary Purpose: To identify and validate the efficacious monotherapy dosing regimen for topiramate in children aged 2 to
Autor:
Wendy P. Battisti, Astrid Gendolla, Eric C. Yuen, Paul Winner, Steven Wang, Jeffrey S. Nye, Catherine Stayer
Publikováno v:
Headache: The Journal of Head and Face Pain. 46:1503-1510
Objective.—To characterize the efficacy and safety of topiramate for migraine prevention in adolescents from 3 randomized, 26-week, double-blind, placebo-controlled trials. Background.—Limited information is available regarding the efficacy and s
Autor:
Tom Verhaeghe, Arash Raoufinia, Qinying Zhao, Yolande Walschap, Jeffrey S. Nye, Steven Ramael, Mukund Padmanabhan, Michael Gold, Caiping Yao
Publikováno v:
The Journal of Clinical Pharmacology. 45:519-528
To evaluate the effect of multiple doses of memantine on the pharmacokinetics of galantamine and to assess the safety and tolerability of galantamine with adjunctive memantine treatment, an open-label, single-center, drug interaction study was conduc
Autor:
Elli Meeropol, David G. McLone, N. Lasarsky, Arthur S. Aylsworth, K. Sawin, Philip Mack, Connie Buran, Jason D. Allen, Joanna Aben, Preston Hammock, Alexander G. Bassuk, Evadnie Rampersaud, Gordon Worley, David S. Enterline, Timothy J. Brei, Laura E. Mitchell, Marion L. Walker, Sandra G. West, Deborah G. Siegel, John A. Kessler, Bermans J. Iskandar, W. J. Oakes, Lorraine Mehltretter, Joanne Mackey, L. E. Floyd, Elizabeth C. Melvin, Marcy C. Speer, Roger E. Stevenson, Timothy M. George, Joy Ito, Jeffrey S. Nye, John R. Gilbert, Joann Bodurtha, Cynthia M. Powell
Publikováno v:
Journal of Medical Genetics. 42:940-946
Neural tube defects (NTDs) are the second most common birth defects (1 in 1000 live births) in the world. Periconceptional maternal folate supplementation reduces NTD risk by 50–70%; however, studies of folate related and other developmental genes
Publikováno v:
Journal of Biological Chemistry. 280:6663-6668
Mutations in genes encoding presenilins (PS1 and PS2) are responsible for the majority of early onset familial Alzheimer's disease. PS, a critical component of gamma-secretase, is responsible for the intramembranous cleavage of amyloid precursor prot
Autor:
Wenning Qin, Rongqing Shuang, Gregory J. Fici, Richard L. Myers, Adele M. Pauley, Chai An Mao, Ismail Kola, Jinhe Li, Carol S Himes, Gregory P. Donoho, Jeffrey S. Nye, Kalpana M. Merchant
Publikováno v:
Journal of Biological Chemistry. 278:33445-33449
Nicastrin is a component of the gamma-secretase complex that has been shown to adhere to presenilin-1 (PS1), Notch, and APP. Here we demonstrate that Nicastrin-deficient mice showed a phenotype that is indistinguishable from PS1/PS2 double knock-out
Autor:
Timothy M. George, Joann Bodurtha, Joanna Aben, Mark S. Dias, Evadnie Rampersaud, Jeffrey S. Nye, Deborah G. Siegel, Connie Buran, David G. McLone, Lorraine Mehltretter, Timothy J. Brei, Marion L. Walker, Nicole Lasarsky, Margaret E. Dickerson, Bonnie Ohm, Elizabeth C. Melvin, Arthur S. Aylsworth, Kathleen Sawin, Marcy C. Speer, W. Jerry Oakes, Cynthia M. Powell, Joy Ito, Bermans J. Iskandar, David S. Enterline, Paula Peterson
Publikováno v:
Clinical Genetics. 63:210-214
Folate supplementation appears to reduce the risk for neural tube defects (NTDs). Methylenetetrahydrofolate reductase (MTHFR) is a candidate gene in the folate metabolism pathway that has been extensively studied in different human populations. We ex