Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Jeffrey S. Nicoson"'
Autor:
Nikki Parker, Joseph A. Reddy, Christopher P. Leamon, Marilynn Vetzel, Elaine Westrick, Iontcho Radoslavov Vlahov, Jeffrey S. Nicoson
Publikováno v:
International Journal of Cancer. 121:1585-1592
EC140 is a water soluble folate conjugate of desacetylvinblastine monohydrazide (DAVLBH), which is constructed with an endosome-cleavable acyl hydrazone bond. This agent has proven to be active and specific against well established, subcutaneous fola
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45c885c7e2a86d8010a6338169f1633e
https://doi.org/10.1002/ijc.22853
https://doi.org/10.1002/ijc.22853
Autor:
Nikki Parker, Le-Cun Xu, Elaine Westrick, Iontcho Radoslavov Vlahov, Jeffrey S. Nicoson, Marilynn Vetzel, Joseph A. Reddy, Christopher P. Leamon
Publikováno v:
Bioconjugate Chemistry. 16:803-811
A novel folate conjugate of mitomycin C, herein referred to as EC72, was designed and evaluated for biological activity against FR-positive cells and tumors. EC72 was produced by coupling folic acid-gamma-cysteine to 7-N-modified MMC via a disulfide
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e264b870b4a02a10d557010a4d966217
https://doi.org/10.1021/bc049709b
https://doi.org/10.1021/bc049709b
Publikováno v:
Chemical Research in Toxicology. 18:501-508
The reactions of aqueous ClO2 with tyrosine, N-acetyltyrosine, and dopa (3,4-dihydroxyphenylalanine) are investigated from pH 4 to 7. The reaction rates increase greatly with pH to give a series of oxidized products. Tyrosine and N-acetyltyrosine hav
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d0201c44c045350b6fdf0281feaf8adc
https://doi.org/10.1021/tx049697i
https://doi.org/10.1021/tx049697i
Publikováno v:
Inorganic Chemistry. 43:7412-7420
Chloride ion catalyzes the reactions of HOBr with bromite and chlorite ions in phosphate buffer (p[H(+)] 5 to 7). Bromine chloride is generated in situ in small equilibrium concentrations by the addition of excess Cl(-) to HOBr. In the BrCl/ClO(2)(-)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47b480e71a953902bdd095c36dfd924d
https://doi.org/10.1021/ic048982m
https://doi.org/10.1021/ic048982m
Publikováno v:
Inorganic Chemistry. 42:5818-5824
The reaction between BrO2(-) and excess HOCl (p[H+] 6-7, 25.0 degrees C) proceeds through several pathways. The primary path is a multistep oxidation of HOCl by BrO(2)(-) to form ClO(3)(-) and HOBr (85% of the initial 0.15 mM BrO(2)(-)). Another path
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15785729b4e6fb354fb9b62885a9fd1c
https://doi.org/10.1021/ic0301223
https://doi.org/10.1021/ic0301223
Autor:
Jeffrey S. Nicoson, Lu Wang, Robert H. Becker, Dale W. Margerum, Charles E. Muller, Kara E. Huff Hartz
Publikováno v:
Inorganic Chemistry. 41:2975-2980
Ozone reactions with XO(2)(-) (X = Cl or Br) are studied by stopped-flow spectroscopy under pseudo-first-order conditions with excess XO(2)(-). The O(3)/XO(2)(-) reactions are first-order in [O(3)] and [XO(2)(-)], with rate constants k(1)(Cl) = 8.2(4
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c68626cd5c7b6efe5cb89cb652a2213f
https://doi.org/10.1021/ic011301s
https://doi.org/10.1021/ic011301s
Publikováno v:
Inorganic Chemistry. 41:108-113
The rate of ClO(2) conversion to ClO(2)(-) and ClO(3)(-) is accelerated by BrO(2)(-), repressed by ClO(2)(-), and greatly assisted by many nucleophiles (Br(-)PO(4)(3-)HPO(4)(2-)CO(3)(2-)Cl(-) approximately OH(-)CH(3)COO(-) approximately SO(4)(2-) app
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a889e1c8a0ded3a644db222838f7f45
https://doi.org/10.1021/ic010849w
https://doi.org/10.1021/ic010849w
Autor:
Nikki Parker, Patrick J. Klein, Joseph A. Reddy, Alicia Bloomfield, Edward A. Sausville, Christopher P. Leamon, Iontcho Radoslavov Vlahov, Kristen Bruna, Jeffrey S. Nicoson, Melissa Nelson, Richard A. Messmann, Mark A Gehrke, Elaine Westrick, Ryan Dorton, Marilynn Vetzel, Patricia LoRusso
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 336(2)
During a phase I trial of EC145 (a folate-targeted vinca alkaloid conjugate), constipation was identified as the dose-limiting toxicity, probably from a nonfolate receptor-related liver clearance process capable of releasing unconjugated vinca alkalo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c7bcd2a765db567e5aba0c40fc334687
https://pubmed.ncbi.nlm.nih.gov/20978169
https://pubmed.ncbi.nlm.nih.gov/20978169
Autor:
Marilynn Vetzel, Yu Wang, Christopher P. Leamon, Patrick J. Klein, Iontcho Radoslavov Vlahov, Elaine Westrick, Ryan Dorton, Alicia Dawson, Jeffrey S. Nicoson, Joseph A. Reddy, Nikki Parker
Publikováno v:
Molecular pharmaceutics. 6(5)
Herein we report on the potencies of 4 related folate-conjugated tubulysins constructed with either tubulysin B hydrazide (EC0305), tubulysin A hydrazide (EC0510), the N,O-acetal derivative of natural tubulysins (EC0317) or a tubulysin B ester (EC030
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad1074d55d156012ff575c496bd4ff59
https://pubmed.ncbi.nlm.nih.gov/19630399
https://pubmed.ncbi.nlm.nih.gov/19630399
Publikováno v:
Inorganic chemistry. 42(24)
The reaction of chlorine dioxide with excess NO(2)(-) to form ClO(2)(-) and NO(3)(-) in the presence of a large concentration of ClO(2)(-) is followed via stopped-flow spectroscopy. Concentrations are set to establish a preequilibrium among ClO(2), N
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0400e525c752163d400ea6b3fa3c3a02
https://pubmed.ncbi.nlm.nih.gov/14632511
https://pubmed.ncbi.nlm.nih.gov/14632511