Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Jeffrey S. Mugridge"'
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-10 (2018)
The decapping enzyme Dcp2 removes the 5′ eukaryotic cap from mRNA transcripts and acts in concert with its essential activator Dcp1 and various coactivators. Here the authors present the structure of the fully-activated mRNA decapping complex, whic
Externí odkaz:
https://doaj.org/article/681911898ec044a5a3ff6a9259b7e8b3
Autor:
Marcelina Bednarczyk, Jessica K. Peters, Renata Kasprzyk, Jagoda Starek, Marcin Warminski, Tomasz Spiewla, Jeffrey S. Mugridge, John D. Gross, Jacek Jemielity, Joanna Kowalska
Publikováno v:
ACS Chemical Biology. 17:1460-1471
Vaccinia virus (VACV) represents a family of poxviruses, which possess their own decapping machinery as a part of their strategy to eliminate host mRNAs and evade the innate immune response. D9 is one of the two encoded VACV decapping enzymes that is
Autor:
Angel D’Oliviera, Xuhang Dai, Saba Mottaghinia, Evan P. Geissler, Lucie Etienne, Yingkai Zhang, Jeffrey S. Mugridge
Publikováno v:
bioRxiv
The SARS-CoV-2 main protease (Mpro) plays a crucial role in the production of functional viral proteins during infection and, like many viral proteases, can also target and cleave host proteins to subvert their cellular functions. Here, we show that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8a092c11074627e4e9ce2ddf8cba78a
https://doi.org/10.1101/2023.02.20.529306
https://doi.org/10.1101/2023.02.20.529306
Publikováno v:
The FASEB Journal. 36
Publikováno v:
Nature Structural & Molecular Biology. 25:1077-1085
5'-3' RNA decay pathways are critical for quality control and regulation of gene expression. Structural and biochemical studies have provided insights into the key nucleases that carry out deadenylation, decapping, and exonucleolysis during 5'-3' dec
Autor:
Michael D. Pluth, Carmelo Sgarlata, Giuseppe Arena, Valeria Zito, Jeffrey S. Mugridge, Kenneth N. Raymond
Publikováno v:
Chemistry – A European Journal. 23:16813-16818
The supramolecular assembly [Ga4 L6 ]12- acts as a nanoscale flask to mediate the reactivity of encapsulated reactive guests and also functions as a catalyst to carry out enzyme-like chemical transformations. The guest binding to the interior cavity
Autor:
John D. Gross, Jeffrey S. Mugridge
Publikováno v:
The EMBO journal, vol 37, iss 23
Focal deletions occur frequently in the cancer genome. However, the putative tumor‐suppressive genes residing within these regions have been difficult to pinpoint. To robustly identify these genes, we implemented a computational approach based on n
Publikováno v:
Nature communications, vol 9, iss 1
Nature Communications, Vol 9, Iss 1, Pp 1-10 (2018)
Mugridge, JS; Tibble, RW; Ziemniak, M; Jemielity, J; & Gross, JD. (2018). Structure of the activated Edc1-Dcp1-Dcp2-Edc3 mRNA decapping complex with substrate analog poised for catalysis. NATURE COMMUNICATIONS, 9. doi: 10.1038/s41467-018-03536-x. UC San Francisco: Retrieved from: http://www.escholarship.org/uc/item/913482ms
Nature Communications
Nature Communications, Vol 9, Iss 1, Pp 1-10 (2018)
Mugridge, JS; Tibble, RW; Ziemniak, M; Jemielity, J; & Gross, JD. (2018). Structure of the activated Edc1-Dcp1-Dcp2-Edc3 mRNA decapping complex with substrate analog poised for catalysis. NATURE COMMUNICATIONS, 9. doi: 10.1038/s41467-018-03536-x. UC San Francisco: Retrieved from: http://www.escholarship.org/uc/item/913482ms
Nature Communications
The conserved decapping enzyme Dcp2 recognizes and removes the 5′ eukaryotic cap from mRNA transcripts in a critical step of many cellular RNA decay pathways. Dcp2 is a dynamic enzyme that functions in concert with the essential activator Dcp1 and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5e1ee40084c0ff4b181da97cc1e1417
https://escholarship.org/uc/item/913482ms
https://escholarship.org/uc/item/913482ms
Publikováno v:
RNA (New York, N.Y.), vol 24, iss 2
Changes in the 5′ leader of an mRNA can have profound effects on its translational efficiency with little effect on abundance. Sequencing-based methods to accurately map the 5′ leader by identifying the first transcribed nucleotide rely on enzyma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79c986501a452b65301cebc937ceab47
https://escholarship.org/uc/item/1hk6p2n0
https://escholarship.org/uc/item/1hk6p2n0
Publikováno v:
Nature Structural & Molecular Biology. 26:147-148