Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Jeffrey S. Kief"'
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
ADAR1 is an interferon-induced enzyme that catalyzes editing of adenine to inosine across the transcriptome as part of the immune response. Here the authors establish how ADAR1 recognizes non-CpG RNA sequences to facilitate the formation of A-Z junct
Externí odkaz:
https://doaj.org/article/75d14e461d4e48f38695886425928e67
Autor:
Quentin Vicens, Jeffrey S. Kieft
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 19, Iss , Pp 4373-4380 (2021)
What viral RNA genomes lack in size, they make up for in intricacy. Elaborate RNA structures embedded in viral genomes can hijack essential cellular mechanisms aiding virus propagation. Exoribonuclease-resistant RNAs (xrRNAs) are an emerging class of
Externí odkaz:
https://doaj.org/article/3f005c2356b74a99964bb916d6b6714e
Publikováno v:
mBio, Vol 11, Iss 5 (2020)
ABSTRACT Viruses have developed innovative strategies to exploit the cellular machinery and overcome the antiviral defenses of the host, often using specifically structured RNA elements. Examples are found in the Flavivirus genus (in the family Flavi
Externí odkaz:
https://doaj.org/article/d1ae018e462d4548866e69c7eeefe8b4
Autor:
Erik W. Hartwick, David A. Costantino, Andrea MacFadden, Jay C. Nix, Siqi Tian, Rhiju Das, Jeffrey S. Kieft
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
Complex RNA three-dimensional structures undergo functionally important programmed conformational changes. Here, the authors report how two structurally and functionally coupled RNA domains within a viral 3′-UTR sense the ribosome through conformat
Externí odkaz:
https://doaj.org/article/9e3575109598441c9bf349e416a47825
Autor:
Andrea MacFadden, Zoe O’Donoghue, Patricia A. G. C. Silva, Erich G. Chapman, René C. Olsthoorn, Mark G. Sterken, Gorben P. Pijlman, Peter J. Bredenbeek, Jeffrey S. Kieft
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
Subgenomic flavivirus RNAs are generated by a host exoribonuclease and play an important role in virus replication and pathogenesis. Here, the authors show the mechanism by which subgenomic flavivirus RNAs are generated and identify two structurally
Externí odkaz:
https://doaj.org/article/b7039c42c77c4ec68cc74cfb0a5e0764
Publikováno v:
mBio, Vol 9, Iss 6 (2018)
ABSTRACT Many viruses produce protein-coding and noncoding subgenomic RNAs (sgRNAs) that are critical for infection. A recently discovered pathway for viral sgRNA production uses exoribonuclease-resistant RNAs (xrRNAs), discrete folded RNA elements t
Externí odkaz:
https://doaj.org/article/ed96e129305943a59a98aa98b36203f1
Autor:
Megan E. Filbin, Jeffrey S. Kieft
Publikováno v:
F1000Research, Vol 5 (2016)
Communication between the 5′ and 3′ ends of a eukaryotic messenger RNA (mRNA) or viral genomic RNA is a ubiquitous and important strategy used to regulate gene expression. Although the canonical interaction between initiation factor proteins at t
Externí odkaz:
https://doaj.org/article/6f59e260b86f46b1ad78a1c4a8c9c174
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
The authors describe a functional crosstalk between the p53 network and the integrated stress response through the p53 repressor PPM1D. Inhibition of PPM1D potentiates p53-dependent transactivation and apoptosis via induction of the HRI-eIF2α-ATF4 p
Externí odkaz:
https://doaj.org/article/ba96d94410b24d0bac5244271212e7b7
Autor:
Lewis Rolband, Damian Beasock, Yang Wang, Yao-Gen Shu, Jonathan D. Dinman, Tamar Schlick, Yaoqi Zhou, Jeffrey S. Kieft, Shi-Jie Chen, Giovanni Bussi, Abdelghani Oukhaled, Xingfa Gao, Petr Šulc, Daniel Binzel, Abhjeet S. Bhullar, Chenxi Liang, Peixuan Guo, Kirill A. Afonin
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 20, Iss , Pp 6120-6137 (2022)
The International Society of RNA Nanotechnology and Nanomedicine (ISRNN) serves to further the development of a wide variety of functional nucleic acids and other related nanotechnology platforms. To aid in the dissemination of the most recent advanc
Externí odkaz:
https://doaj.org/article/a7b658ecc43d44eeabee93b85ac3c176
Autor:
Jeffrey S. Kief
Publikováno v:
Non-Protein Coding RNAs ISBN: 9783540708339
Internal ribosome entry sites (IRES) are non-protein coding RNAs that can drive translation initiation using RNA in place of protein factors and the modified nucleotide cap. IRESs are critical for successful infection by many viruses and may be an im
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b55fd21ec6f47560d9622c141c579203
https://doi.org/10.1007/978-3-540-70840-7_16
https://doi.org/10.1007/978-3-540-70840-7_16
