Zobrazeno 1 - 10
of 555
pro vyhledávání: '"Jeffrey S. Hyams"'
Publikováno v:
PLoS ONE, Vol 19, Iss 3 (2024)
Externí odkaz:
https://doaj.org/article/a3420c26fc634c369d2d2e0f29c9274d
Autor:
Suresh Venkateswaran, Hari K. Somineni, Jason D. Matthews, Varun Kilaru, Jeffrey S. Hyams, Lee A. Denson, Richard Kellamayer, Greg Gibson, David J. Cutler, Karen N. Conneely, Alicia K. Smith, Subra Kugathasan
Publikováno v:
Clinical Epigenetics, Vol 15, Iss 1, Pp 1-16 (2023)
Abstract Background In peripheral blood, DNA methylation (DNAm) patterns in inflammatory bowel disease patients reflect inflammatory status rather than disease status. Here, we examined DNAm in diseased rectal mucosa from ulcerative colitis (UC) pati
Externí odkaz:
https://doaj.org/article/775c2f58680944ca846097a854389076
Autor:
Tzipi Braun, Katya E. Sosnovski, Amnon Amir, Marina BenShoshan, Kelli L. VanDussen, Rebekah Karns, Nina Levhar, Haya Abbas-Egbariya, Rotem Hadar, Gilat Efroni, David Castel, Camila Avivi, Michael J. Rosen, Anne M. Grifiths, Thomas D. Walters, David R. Mack, Brendan M. Boyle, Syed Asad Ali, Sean R. Moore, Melanie Schirmer, Ramnik J. Xavier, Subra Kugathasan, Anil G. Jegga, Batya Weiss, Chen Mayer, Iris Barshack, Shomron Ben-Horin, Igor Ulitsky, Anthony Beucher, Jorge Ferrer, Jeffrey S. Hyams, Lee A. Denson, Yael Haberman
Publikováno v:
JCI Insight, Vol 8, Iss 14 (2023)
Ulcerative colitis (UC), Crohn’s disease (CD), and celiac disease are prevalent intestinal inflammatory disorders with nonsatisfactory therapeutic interventions. Analyzing patient data-driven cohorts can highlight disease pathways and new targets f
Externí odkaz:
https://doaj.org/article/175d48f8e9c64094a115fe7ffb8e26b5
Autor:
Ranjit Pelia, Suresh Venkateswaran, Jason D. Matthews, Yael Haberman, David J. Cutler, Jeffrey S. Hyams, Lee A. Denson, Subra Kugathasan
Publikováno v:
BMC Medical Genomics, Vol 14, Iss 1, Pp 1-15 (2021)
Abstract Background Crohn’s disease (CD) is a heritable chronic inflammatory disorder. Non-coding RNAs (ncRNAs) play an important role in epigenetic regulation by affecting gene expression, but can also directly affect protein function, thus having
Externí odkaz:
https://doaj.org/article/985f433f52b8425b84594cdba42bea7c
Publikováno v:
Frontiers in Pain Research, Vol 2 (2021)
Objectives: Functional Abdominal Pain (FAP) and Irritable Bowel Syndrome (IBS) are common recurrent abdominal pain diagnoses with the hallmark, lack of inflammation. To identify a biological signature for IBS/FAP in the colon, this study used genetic
Externí odkaz:
https://doaj.org/article/f271894650fb463e8ebf971d5c41ec8e
Autor:
Yael Haberman, Rebekah Karns, Phillip J. Dexheimer, Melanie Schirmer, Judith Somekh, Ingrid Jurickova, Tzipi Braun, Elizabeth Novak, Laura Bauman, Margaret H. Collins, Angela Mo, Michael J. Rosen, Erin Bonkowski, Nathan Gotman, Alison Marquis, Mason Nistel, Paul A. Rufo, Susan S. Baker, Cary G. Sauer, James Markowitz, Marian D. Pfefferkorn, Joel R. Rosh, Brendan M. Boyle, David R. Mack, Robert N. Baldassano, Sapana Shah, Neal S. Leleiko, Melvin B. Heyman, Anne M. Grifiths, Ashish S. Patel, Joshua D. Noe, Bruce J. Aronow, Subra Kugathasan, Thomas D. Walters, Greg Gibson, Sonia Davis Thomas, Kevin Mollen, Shai Shen-Orr, Curtis Huttenhower, Ramnik J. Xavier, Jeffrey S. Hyams, Lee A. Denson
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
The severity of ulcerative colitis, and response to treatment, is highly variable. Here, the authors examine rectal gene expression signatures and faecal microbiomes of children and adults with the disease and provide new insights in to pathogenesis.
Externí odkaz:
https://doaj.org/article/cbe3d637f8854aa08026fcc4f3d0a9e7
Autor:
Lorenza Bellusci, Fatema Tuz Zahra, Dena E. Hopkins, Juan C. Salazar, Jeffrey S. Hyams, Surender Khurana
Publikováno v:
Gastroenterology. 163:1672-1675
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7d69253b8d1b1c8bb308538fb14077a
https://doi.org/10.1053/j.gastro.2022.08.009
https://doi.org/10.1053/j.gastro.2022.08.009
Autor:
Kathryn Clarkston, Rebekah Karns, Anil G Jegga, Mihika Sharma, Sejal Fox, Babajide A Ojo, Phillip Minar, Thomas D Walters, Anne M Griffiths, David R Mack, Brendan Boyle, Neal S LeLeiko, James Markowitz, Joel R Rosh, Ashish S Patel, Sapana Shah, Robert N Baldassano, Marian Pfefferkorn, Cary Sauer, Subra Kugathasan, Yael Haberman, Jeffrey S Hyams, Lee A Denson, Michael J Rosen
Publikováno v:
J Crohns Colitis
Background and AimsWe aimed to determine whether a targeted gene expression panel could predict clinical outcomes in paediatric ulcerative colitis [UC] and investigated putative pathogenic roles of predictive genes.MethodsIn total, 313 rectal RNA sam
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22599f11cd62c1ce64aa7c303dab9246
https://pubmed.ncbi.nlm.nih.gov/35665804
https://pubmed.ncbi.nlm.nih.gov/35665804
Publikováno v:
Journal of Pediatric Gastroenterology & Nutrition. 74:610-616
Ileocolonoscopy (IC) detects mucosal inflammation and magnetic resonance enterography (MRE) detects transmural inflammation in Crohn disease (CD). We aimed to evaluate the relationship between the simplified magnetic resonance index of activity (MARI
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d27bc63152131074679e15ed17d73b0
https://doi.org/10.1097/mpg.0000000000003412
https://doi.org/10.1097/mpg.0000000000003412
Autor:
Nicholas M Croft, Lissy de Ridder, Anne M Griffiths, Jeffrey S Hyams, Frank M Ruemmele, Dan Turner, Katharine Cheng, Irja Lutsar, Marco Greco, Zuzanna Gołębiewska, Floriane Laumond, Maria Cavaller-Bellaubi, Adam Elgreey, Tara A Altepeter, Chrissi Pallidis, Koen Norga, Robert Nelson, Wallace Crandall, Gilles Vassal
Publikováno v:
Journal of Crohn's & colitis, 17(2), 249-258. Oxford University Press
Background and Aims Despite recent approvals for new drugs to treat adults with Crohn’s disease or ulcerative colitis, there are only two approved advanced treatment options [infliximab and adalimumab] for children with inflammatory bowel disease [
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2933fe299ef362ab1142f48b39899f72
https://pure.eur.nl/en/publications/557fd4fd-0e74-4060-9c04-8b295ed80eae
https://pure.eur.nl/en/publications/557fd4fd-0e74-4060-9c04-8b295ed80eae
