Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Jeffrey S. Hrkach"'
Publikováno v:
Journal of Polymer Science Part A: Polymer Chemistry. 38:1277-1282
New degradable poly(ether-anhydride) networks were synthesized by UV photopolymerization. Dicarboxylated poly(ethylene glycol) (PEG) or poly(tetramethylene glycol) (PTMG) was reacted with an excess of methacrylic anhydride to form dimethacrylated mac
Publikováno v:
Proceedings of the National Academy of Sciences. 96:10344-10348
The three most common methods of sterilization in use today are ethylene oxide exposure, γ-irradiation, and steam sterilization. Each of these methods has serious limitations for the sterilization of some materials used in medicine, especially therm
Autor:
Burkhard Kriwet, Giovanni Caponetti, Noah Lotan, Paolo Colombo, Melissa Poh, Robert Langer, Jeffrey S. Hrkach
Publikováno v:
Journal of Pharmaceutical Sciences. 88:136-141
The preparation and characterization of microparticles produced from a new class of functionalized, biodegradable, comblike graft copolymers is presented. The copolymers are polyester-polyamino acid hybrids, composed of a poly(L-lactic acid-co-L-lysi
Autor:
Ivette M. Johnson, Nicholas N. Gao, Utpal B. Pajvani, Robert Langer, Jeffrey S. Hrkach, Scott M. Cannizzaro, Alonzo D. Cook
Publikováno v:
Journal of Biomedical Materials Research. 35:513-523
The design of biomaterials containing specific ligands on the surface offers the possibility of creating materials that can interact with and potentially control mammalian cell behavior. Biodegradable materials further provide the significant advanta
Publikováno v:
Macromolecules. 28:4736-4739
Publikováno v:
Journal of Polymer Science Part A: Polymer Chemistry. 33:285-298
Trimethylsilyl triflate (TMSOTf) can be used as an initiator for the cationic polymerization of alkenes and heterocycles. However, TMSOTf without additives and promoters acts inefficiently. Initiation in the cationic polymerization of tetrahydrofuran
Publikováno v:
Journal of Inorganic and Organometallic Polymers. 5:183-193
Poly(methylphenylsilylene) has been functionalized by protodearylation with trifluoromethanesulfonic acid. Comb-like graft copolymers have been prepared by polymerizing tetrahydrofuran. 2-methyl-2-oxazoline, and isobutylvinyl ether from a partially t
Publikováno v:
Macromolecules. 28:59-72
Monomodal polysilylenes with relatively narrow molecular weight distributions (M sub w/M sub n) < 1.5) have been prepared by the reductive coupling of methylphenyldichlorosilane and di-n-hexyldichlorosilane with alkali metals in toluene in the presen
Autor:
Tina Van Geen Hoven, Daniel D. Von Hoff, Kevin McDonnell, Allen Horhota, James Wright, Erick Peeke, Jason Auer, Stephen E. Zale, Abhimanyu Sabnis, Jason Summa, Michael Figa, Young-Ho Song, Mir Mukkaram Ali, David De Witt, Greg Troiano, Edward Schnipper, Jeffrey J. Song, Susan Low, Omid C. Farokhzad, Beadle Retnarajan, Tarikh Christopher Campbell, Douglas Tompsett, Elizaveta Andrianova, Christopher Sweeney, Jeffrey S. Hrkach, Neil H. Bander, Philip W. Kantoff, Robert Langer, Maria Figueiredo, Patricia LoRusso
Publikováno v:
Science Translational Medicine. 4
We describe the development and clinical translation of a targeted polymeric nanoparticle (TNP) containing the chemotherapeutic docetaxel (DTXL) for the treatment of patients with solid tumors. DTXL-TNP is targeted to prostate-specific membrane antig
Publikováno v:
Journal of Polymer Science Part A: Polymer Chemistry. 32:1949-1956
The synthesis of γ;-methoxypropylmethyldichlorosilane, and its subsequent polymerization and copolymerization with di;-n;-hexyldichlorosilane through the reductive coupling with sodium has been accomplished. The resulting polymers contain methyl eth