Výsledky vyhledávání - "Jeffrey S. Carter"

Elektronická kniha

Die Geheimnisse des Ägyptischen Totenbuchs : Pfade ins Jenseits

Autor: Jeffrey S. Carter

Entdecken Sie die verborgenen Weisheiten und tiefgründigen Rituale einer der faszinierendsten Zivilisationen der Menschheitsgeschichte. In'Die Geheimnisse des Ägyptischen Totenbuchs: Pfade ins Jenseits'nimmt Jeffrey S. Carter Sie mit auf eine Reise

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Discovery and SAR of PF-4693627, a potent, selective and orally bioavailable mPGES-1 inhibitor for the potential treatment of inflammation

Autor: John Robert Springer, Gina M. Jerome, Hayes Michael J, Michael T. Baratta, Daniel P. Walker, Graciela B. Arhancet, Alexander F. Shaffer, Jaime L. Masferrer, Ben S. Zweifel, Steven E. Heasley, Darin E. Jones, William M. Moore, Jeffrey S. Carter, Yvette M. Fobian, Michael L. Vazquez, Sue Metz

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 23:1114-1119

Inhibition of mPGES-1, the terminal enzyme in the arachidonic acid/COX pathway to regulate the production of pro-inflammatory prostaglandin PGE2, is considered an attractive new therapeutic target for safe and effective anti-inflammatory drugs. The d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b121fd58b89ecf308dd263c517c877ef
https://doi.org/10.1016/j.bmcl.2012.11.109

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Synthesis and biological evaluation of substituted benzoxazoles as inhibitors of mPGES-1: Use of a conformation-based hypothesis to facilitate compound design

Autor: Daniel P. Walker, Alexander F. Shaffer, William M. Moore, Michael T. Baratta, Sue Metz, Jeffrey A. Scholten, John Robert Springer, Jeffrey S. Carter, Hwang-Fun Lu, Steven E. Heasley, Yvette M. Fobian, Natasha M. Kablaoui, Francisco M. Franco, Li Xing, Shengtian Yang, Hanau Cathleen E, Michael L. Vazquez, Graciela B. Arhancet, Gina M. Jerome

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 23:1120-1126

Microsomal prostaglandin E(2) synthase-1 (mPGES-1) is a novel therapeutic target for the treatment of inflammation and pain. In the preceding letter, we detailed the discovery of clinical candidate PF-04693627, a potent mPGES-1 inhibitor possessing a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b2d05bf0698be13f2291735a95c4465f
https://doi.org/10.1016/j.bmcl.2012.11.107

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Distinction of microsomal prostaglandin E synthase-1 (mPGES-1) inhibition from cyclooxygenase-2 inhibition in cells using a novel, selective mPGES-1 inhibitor

Autor: Stephen J. Mnich, Olga V. Nemirovskiy, James K. Gierse, Gabriel Mbalaviele, Adele M. Pauley, Alexander F. Shaffer, William M. Moore, Sumathy Mathialagan, Ben S. Zweifel, Jeffrey S. Carter, Jaime L. Masferrer, Michael L. Vazquez, Jane L. Wang

Publikováno v: Biochemical Pharmacology. 79:1445-1454

Inflammation-induced microsomal prostaglandin E synthase-1 (mPGES-1) is the terminal enzyme that synthesizes prostaglandin E(2) (PGE(2)) downstream of cyclooxygenase-2 (COX-2). The efficacy of nonsteroidal anti-inflammatory drugs and COX-2 inhibitors

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52f2b47310c2ae7d1f319e11e57535cc
https://doi.org/10.1016/j.bcp.2010.01.003

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Liver tissue engineering based on poly (ethylen glycol) hydrogels

Autor: Lee, Won Jae. Frank, C. W., Glenn, Jeffrey S., Carter, Dennis R.

Thesis (Ph.D.)--Stanford University, 2010.
Submitted to the Department of Mechanical Engineering.

Externí odkaz: http://purl.stanford.edu/ry026wx3887

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Homo-timeric structural model of human microsomal prostaglandin E synthase-1 and characterization of its substrate/inhibitor binding interactions

Autor: William M. Moore, James K. Gierse, Ronald B. Frazier, Joseph J. McDonald, Jeffrey S. Carter, Ravi G. Kurumbail, Robin A. Weinberg, Li Xing, Michael L. Vazquez, Michael S. Davies, Nicole Caspers, Hideji Fujiwara

Publikováno v: Journal of computer-aided molecular design. 23(1)

Inducible, microsomal prostaglandin E synthase 1 (mPGES-1), the terminal enzyme in the prostaglandin (PG) biosynthetic pathway, constitutes a promising therapeutic target for the development of new anti-inflammatory drugs. To elucidate structure-func

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6d96b7dcee4ff77c17f8baee30b3871
https://pubmed.ncbi.nlm.nih.gov/18777160

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Amino acid derivatives that stabilized secondary structures of polypeptides—III. β-Enaminonitriles as analogs of secondary amides. The MCC group—1-acylamino-2-aminoalkyl-3-cyano-2-cyclopentenes as amino acid analogs

Autor: D. S. Kemp, Jeffrey S. Carter

Publikováno v: Tetrahedron Letters. 28:4641-4644

The properties of β-cyanoenamines as analogs of amides are studied with derivatives of a rigid amino acid equivalent—Mcc = 1,2-diamino-3-cyanocyclopentene, prepared in two steps from methyl 2-(N-Boc-amino)-5-cyanopentanoate. Racemation of Mcc and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::73fe2019f0acfa0019c0e4aa6baf535d
https://doi.org/10.1016/s0040-4039(00)96585-7

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