Zobrazeno 1 - 10
of 33
pro vyhledávání: '"Jeffrey S. Buzby"'
Publikováno v:
Genes, Vol 13, Iss 12, p 2302 (2022)
Li-Fraumeni Syndrome (LFS) is an autosomal dominant disorder where an oncogenic TP53 germline mutation is inherited by offspring of a carrier parent. p53 is a key tumor suppressor regulating cell cycle arrest in response to DNA damage. Unexpectedly,
Externí odkaz:
https://doaj.org/article/eb24ec89b133408a8154e76ce35c4320
Autor:
David Buchbinder, Matthew J. Smith, Misako Kawahara, Morton J. Cowan, Jeffrey S. Buzby, Roshini S. Abraham
Publikováno v:
Blood Advances, Vol 2, Iss 15, Pp 1828-1832 (2018)
Abstract: DNA ligase 4 deficiency (LIG4-SCID) causes lymphopenia (T-B-NK+) and a radiosensitive SCID (RS-SCID) phenotype. We demonstrate, for the first time, flow cytometric-based kinetic analysis of phosphorylated H2AX (γH2AX) in lymphocyte subsets
Externí odkaz:
https://doaj.org/article/7156acbe38c14fd5a5c2d4a1ecebca7c
Publikováno v:
Brain research bulletin. 161
Whether GPR17 has the same distribution and repair mechanism in immature white matter with periventricular leukomalacia (PVL) as in the adult brain remains to be determined. This study tried to explore the expression phase and site of GPR17, and to i
Publikováno v:
Cancer Genetics. 211:9-17
Li–Fraumeni syndrome (LFS) is an autosomal dominant disorder where an oncogenic TP53 germline mutation is passed from parent to child. Tumor protein p53 is a key tumor suppressor regulating cell cycle arrest in response to DNA damage. Paradoxically
Autor:
Matthew J. Smith, Roshini S. Abraham, Misako Kawahara, Jeffrey S. Buzby, David Buchbinder, Morton J. Cowan
Publikováno v:
Blood advances. 2(15)
DNA ligase 4 deficiency (LIG4-SCID) causes lymphopenia (T-B-NK+) and a radiosensitive SCID (RS-SCID) phenotype. We demonstrate, for the first time, flow cytometric-based kinetic analysis of phosphorylated H2AX (γH2AX) in lymphocyte subsets, especial
Publikováno v:
Neuroscience. 284:444-458
Periventricular leukomalacia (PVL) is one of the foremost neurological conditions leading to long-term abnormalities in premature infants. Since it is difficult to prevent initiation of this damage in utero, promoting the innate regenerative potentia
Publikováno v:
Inflammation Research. 63:299-308
Variable tissue factor (TF) expression by human microvascular endothelial cells (HMVEC) may be regulated by two promoter haplotypes, distinguished by an 18-basepair deletion (D) or insertion (I) at −1,208. We sought to determine the relationship be
Publikováno v:
Brain Research. 1535:38-51
Mounting evidence suggests that endogenous progenitor cells may initiate cerebral WM repair. This study was designed to determine whether endogenous glial progenitor cells derived from either the subventricular zone (SVZ) or the white matter (WM) con
Publikováno v:
Brain Research. 1492:108-121
The contribution of microglial activation to preoligodendroglial (preOL) damage in the central nervous system (CNS) is considered to be one of the principal causes of periventricular leukomalacia (PVL) pathogenesis. The present study explores the eff
Publikováno v:
Brain Research. 1486:112-120
The therapeutic effects of UDP-glucose (UDPG), an endogenous agonist of GPR17 that may promote the self-repair of white matter, glial cell line-derived neurotrophic factor (GDNF), a neurotrophic factor correlated with the growth and survival of nerve