Zobrazeno 1 - 10
of 232
pro vyhledávání: '"Jeffrey S. Barrett"'
Autor:
Jing Liu, Karen Rowland‐Yeo, Almut Winterstein, Simon Dagenais, Qi Liu, Jeffrey S. Barrett, Rui Zhu, Cyrus Ghobadi, Amita Datta‐Mannan, Joy Hsu, Sujatha Menon, Mariam Ahmed, Pooja Manchandani, Paulien Ravenstijn
Publikováno v:
Clinical and Translational Science, Vol 17, Iss 4, Pp n/a-n/a (2024)
Abstract Real‐world data (RWD) and real‐world evidence (RWE) are now being routinely used in epidemiology, clinical practice, and post‐approval regulatory decisions. Despite the increasing utility of the methodology and new regulatory guideline
Externí odkaz:
https://doaj.org/article/ef7db2fce839459fb90fcc8fc8bede48
Engaging student opinions on vaccine development innovation: Experiences from a 'Shark Tank' project
Autor:
Jeffrey S. Barrett, Jeffrey M. Skolnik, Mary Ingram, Yin‐Ming Kuo, Ann E. Metzloff, Ruizhe Jin, Yuanhan Wu, Nik Kroushl
Publikováno v:
Clinical and Translational Science, Vol 17, Iss 2, Pp n/a-n/a (2024)
Abstract A graduate course on vaccine development challenged students to propose concepts to improve upon current vaccine development paradigms in the context of a “Shark Tank‐style” format where students were asked to develop an abbreviated bu
Externí odkaz:
https://doaj.org/article/827811e1583e479aaba38c98a1c05be4
Autor:
Karim Azer, Jeffrey S. Barrett
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology, Vol 11, Iss 7, Pp 797-804 (2022)
Abstract Extrapolation strategies from adult data for designing pediatric drug development programs are explored using the quantitative systems pharmacology (QSP) modeling approach, a mechanistic drug and disease modeling framework that can predict c
Externí odkaz:
https://doaj.org/article/02f82eac1fc140ff9f22bb61652618bf
Autor:
Jeffrey S. Barrett, Scarlett Y. Yang, Kavitha Muralidharan, Victoria Javes, Kemi Oladuja, María Sofía Castelli, Nicole Clayton, Jiaqi Liu, Andre Ramos
Publikováno v:
Clinical and Translational Science, Vol 15, Iss 6, Pp 1380-1386 (2022)
Abstract A course on vaccine development asked students to write a blog addressing general anti‐vaccination strategies and their significance today, in the context of the resistance seen against novel SARS‐CoV‐2 mRNA vaccines. This perspective
Externí odkaz:
https://doaj.org/article/d606c5b6568b406eb4f4edb5e2e15aef
Publikováno v:
Frontiers in Pharmacology, Vol 14 (2023)
Early-stage drug discovery is highly dependent upon drug target evaluation, understanding of disease progression and identification of patient characteristics linked to disease progression overlaid upon chemical libraries of potential drug candidates
Externí odkaz:
https://doaj.org/article/7c8d4413b499407285179f63bff578ba
Autor:
Jeffrey S. Barrett, Megan Cala Pane, Timothy Knab, William Roddy, Jack Beusmans, Eric Jordie, Kanwaljit Singh, Jonathan Michael Davis, Klaus Romero, Michael Padula, Bernard Thebaud, Mark Turner
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
The 21st Century Cures Act requires FDA to expand its use of real-world evidence (RWE) to support approval of previously approved drugs for new disease indications and post-marketing study requirements. To address this need in neonates, the FDA and t
Externí odkaz:
https://doaj.org/article/960476af78be4f2f9cb2ff9675c630bc
Autor:
Jeffrey S. Barrett
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
Externí odkaz:
https://doaj.org/article/a501653c568e44f29d754d30422d0af3
Autor:
Ruth Abrams, Chanchala D. Kaddi, Mengdi Tao, Randolph J. Leiser, Giulia Simoni, Federico Reali, John Tolsma, Paul Jasper, Zachary vanRijn, Jing Li, Bradley Niesner, Jeffrey S. Barrett, Luca Marchetti, M. Judith Peterschmitt, Karim Azer, Susana Neves‐Zaph
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology, Vol 9, Iss 7, Pp 374-383 (2020)
Gaucher’s disease type 1 (GD1) leads to significant morbidity and mortality through clinical manifestations, such as splenomegaly, hematological complications, and bone disease. Two types of therapies are currently approved for GD1: enzyme replacem
Externí odkaz:
https://doaj.org/article/2e477fd9552a478690827a03c69c9f70
Autor:
Penny M. Heaton, Jeffrey S. Barrett
Publikováno v:
Clinical and Translational Science, Vol 13, Iss 2, Pp 224-227 (2020)
Externí odkaz:
https://doaj.org/article/1c6d61eebd3146ada530a2bad48c3c8c
Autor:
Karim Azer, Chanchala D. Kaddi, Jeffrey S. Barrett, Jane P. F. Bai, Sean T. McQuade, Nathaniel J. Merrill, Benedetto Piccoli, Susana Neves-Zaph, Luca Marchetti, Rosario Lombardo, Silvia Parolo, Selva Rupa Christinal Immanuel, Nitin S. Baliga
Publikováno v:
Frontiers in Physiology, Vol 12 (2021)
Mathematical biology and pharmacology models have a long and rich history in the fields of medicine and physiology, impacting our understanding of disease mechanisms and the development of novel therapeutics. With an increased focus on the pharmacolo
Externí odkaz:
https://doaj.org/article/6043edfea4a0400f8fce0c682beb97f9