Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Jeffrey S Tepper"'
Autor:
Graham Paul, Stuart W. Naylor, Nicholas P. Macri, Scott Manetz, Richard Haworth, A. Peter Hall, David Jones, Thierry Flandre, Jeffrey S. Tepper, Michela Gregori, Annick Cauvin, Molly H. Boyle, Sydney Mukaratirwa, Alison Wolfreys, Renaud Fleurance, Inge Tarnow, Kristen J. Nikula, Alessandro Piaia, Mark Price, Ian Robinson, Andrew Allen, Tom Gelzleichter, Mark C Freke, Karyn Colman, Andreas M Hohlbaum, Maurice G Cary
Publikováno v:
Toxicologic Pathology. 49:235-260
The inhalation route is a relatively novel drug delivery route for biotherapeutics and, as a result, there is a paucity of published data and experience within the toxicology/pathology community. In recent years, findings arising in toxicology studie
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::507bdc0e870c9ffe85569d58c5326be1
https://doi.org/10.1177/0192623320976094
https://doi.org/10.1177/0192623320976094
Autor:
Ian Robinson, Simon Moore, Jo Kilgour, Sidney Mukaratirwa, Mark Price, David Jones, Annick Cauvin, Carsten Krantz, Mark C Freke, Andrew Allen, Alison Wolfreys, Jeffrey S Tepper, Scott Manetz, Sherri Dudal, George Karantabias
Publikováno v:
Toxicologic pathology. 49(2)
The inhaled route is still a relatively novel route for delivering biologics and poses additional challenges to those encountered with inhaled small molecules, further complicating the design and interpretation of toxicology studies. A working group
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b786789bd9a095944ef7cb606fe84aff
https://pubmed.ncbi.nlm.nih.gov/33535023
https://pubmed.ncbi.nlm.nih.gov/33535023
Autor:
Richard Malcolmson, Andrew P.-Z. Clark, James B Fink, Plamena Entcheva-Dimitrov, Juergen W. Pfeiffer, Dennis Sullivan, Simon Authier, Kim Bujold, Jeffrey S. Tepper
Publikováno v:
International journal of toxicology. 39(5)
Currently, off-label continuous administration of inhaled epoprostenol is used to manage hemodynamics during mitral valve surgery. A toxicology program was developed to support the use of inhaled epoprostenol during mechanical ventilation as well as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d257de9b3d7c7a73ebba3578c25b239d
https://pubmed.ncbi.nlm.nih.gov/32787636
https://pubmed.ncbi.nlm.nih.gov/32787636
Publikováno v:
Toxicologic pathology. 49(2)
Bronchoalveolar lavage (BAL) is a simple procedure that is used to investigate drug efficacy or lung toxicity. It is sensitive to lung changes and less invasive than histological evaluation. It can be performed repeatedly at interim time points or as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0ac189c2dc3f2fdfd8ec6183894a785
https://pubmed.ncbi.nlm.nih.gov/32519581
https://pubmed.ncbi.nlm.nih.gov/32519581
Autor:
Luqi Pei, Stuart Cracknell, James D. Blanchard, Jeffrey S. Tepper, Philip J. Kuehl, Kristen J. Nikula
Publikováno v:
International Journal of Toxicology. 35:376-392
Developing inhaled drugs requires knowledge of lung anatomy, cell biology, respiratory physiology, particle physics, and some plumbing. Although dose makes the poison, in the context of an inhaled drug, the “dose” is not easily defined. This lack
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::784b1a9ecb2a715f9bf3bfccf8c9eab2
https://doi.org/10.1177/1091581815624080
https://doi.org/10.1177/1091581815624080
Autor:
Jeffrey S. Tepper, Melinda C. Aldrich, Amy M. Stoddard, Dallas M. Hyde, Mclane Michael, Roy C. Levitt, J. Rachel Reader, Edward S. Schelegle
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology. 28:664-672
Interleukin-9 (IL-9) has been strongly implicated in the pathogenesis of asthma, including the overproduction of mucus, in humans and in animal models. We evaluated the inflammatory changes associated with the upregulation of mucus production by exam
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f64e7d26d33ba39d797c3f28fb9c078
https://doi.org/10.1165/rcmb.2002-0207oc
https://doi.org/10.1165/rcmb.2002-0207oc
Autor:
Saurabh Aggarwal, Jason H.T. Bates, Stephen M. Black, Peter F. Bove, James S. Brown, Jared M. Brown, Gary R. Burleson, Stefanie C.M. Burleson, Florence G. Burleson, Alejandro Castañeda, James F. Collawn, Donald N. Cook, Daniel L. Costa, Elvira C. Covarrubias, James D. Crapo, Albert van der Vliet, Aimen K. Farraj, Jane E. Farrington, Robert B. Fick, Aron B. Fisher, Henry J. Forman, W. Michael Foster, Peter Gehr, Andrew J. Gow, Christine M. Gross, Ryan Hadley, Jack R. Harkema, Mehdi Saeed Hazari, Daniel Hirsch, Dallas M. Hyde, Victor J. Johnson, James H. Jones, Pranita Katwa, Murat Kaynar, Debra L. Laskin, Jeffrey D. Laskin, Hui-Hua Li, James D. Londino, Kim E. Longworth, Michael I. Luster, Rama Malaviya, Mark D. Mannie, Andrew T. Mariassy, Sadis Matalon, Stephanie A. Matthes, John T. McBride, Robert R. Mercer, John B. Morris, Hideki Nakano, Stephen G. Olmstead, Janice L. Peake, Kent E. Pinkerton, Bruce R. Pitt, Charles G. Plopper, Robert J. Porcelli, Scott H. Randell, Susan D. Reynolds, Jesse Roman, Philip L. Sannes, Rashmin C. Savani, Richard B. Schlesinger, Madhuri Singal, Suzette Smiley-Jewell, Bernd W. Spur, Claudette M. St. Croix, Judith A. St. George, Jeffrey S. Tepper, Kalidasan Thambiayya, Michael R. Van Scott, Laura S. Van Winkle, Peter D. Wagner, Karla A. Wasserloos, Barry Weinberger, Eric S. White, Kingsley Yin, Berran Yucesoy, Graeme R. Zosky
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2e62b89829d56b396361a4a90abe8368
https://doi.org/10.1016/b978-0-12-404577-4.01002-x
https://doi.org/10.1016/b978-0-12-404577-4.01002-x
Autor:
Daniel L. Costa, Jeffrey S. Tepper
This chapter examines the practical application of lung function tests that are or can be used in laboratory animals that provide analogues of clinical pulmonary function tests conducted on humans. Attention is given to the theory behind how changes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9dd090d44c7b6a74057cb3b4f6662075
https://doi.org/10.1016/b978-0-12-404577-4.00017-5
https://doi.org/10.1016/b978-0-12-404577-4.00017-5
Publikováno v:
The Journal of Immunology. 161:3813-3816
We investigated the role of Th1 or Th2 cells in airway hyperresponsiveness (AHR), because both IFN-γ and IL-4 and IL-5-producing CD4 T cells have been identified in the airways of asthmatics. After transfer of in vitro-generated TCR transgenic Th1 o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::95e32660807c8439cc56c5f62a8d4aa7
https://doi.org/10.4049/jimmunol.161.8.3813
https://doi.org/10.4049/jimmunol.161.8.3813
Autor:
M. J. Wiester, Darrell W. Winsett, Judy H. Richards, Daniel L. Costa, K. M. Crissman, Jeffrey S. Tepper
Publikováno v:
Fundamental and Applied Toxicology. 31:56-64
Ozone (O3) adaptation is a well-known, but poorly understood phenomenon that has been demonstrated in humans and laboratory animals. This study examined pulmonary function and bronchoalveolar lavage fluid (BALF) parameters in O3-adapted F-344 rats to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b32d5309eea1804b7243d87b3f7bfd7
https://doi.org/10.1006/faat.1996.0075
https://doi.org/10.1006/faat.1996.0075